2,800 research outputs found

    Acoustic sensing of renal stone fragmentation in extracorporeal shockwave lithotripsy

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    This thesis describes the research carried out by the author on the exploitation of acoustic emissions detected during extracorporeal shockwave lithotripsy (a non-invasive procedure for the treatment of urinary stones) to develop a new diagnostic system. The work formed part of a research project on lithotripsy undertaken by the University of Southampton in collaboration with Guy's and St Thomas' NHS Foundation Trust (London) and a UK based company, Precision Acoustics Ltd (Dorchester). It takes to a clinical conclusion the proposition made by Leighton and Coleman in 1992 that it might be possible to build a sensor which would automatically exploit these passive acoustic emissions to monitor the efficacy of a lithotripsy treatment. The work, predominantly experimental, involved both in vitro and in vivo investigations. In particular, a first prototype diagnostic system (i.e. sensor plus analysis software) was developed and tested in vitro during trials which included the use of a novel cavitation sensor (on loan from the National Physical Laboratory, Teddington) and stone phantoms designed by the author. This initial system was, then, refined and tested during clinical trials that involved 130 patients. A preliminary trial on 51 patients aimed at refining the system and gathering knowledge on the features of emissions recorded in vivo to produce an on-line monitoring system. This trial was followed by other two trials that compared the output of the on-line acoustic system against the ‘gold standard’ X-Ray assessment of treatments outcomes. The former of these two trials involved 30 patients, and empirically defined the values of the key parameters (identified during the in vitro tests) that would be used as the basis of the diagnosis. In particular, a classification rule of treatments as being successful or unsuccessful was identified, and shown to agree significantly (kappa=0.95) with the ‘gold standard’ follow-up assessment. The latter trial tested the final system on 49 patients and confirmed an accurate treatment classification (kappa=0.94) in terms of the successful/unsuccessful criterion

    Development of a new diagnostic device for extracorporeal shock-wave lithotripsy

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    Extracorporeal Shock-Wave Lithotripsy (ESWL) is the leading technique for the non-invasive treatment of urinary stones. Thousands of ultrasound shocks are focused on the stones in order to break them into fragments small enough to be passed naturally by the body. The procedure is well established, though the re-treatment rate is around 50%. One of the limits of the procedure is that there is no capability for on-line monitoring of the degree of fragmentation of the stone. The output of the treatments could probably be improved if this facility was made available. The underlying physical mechanisms responsible for the break-up of the stone are still subject to investigation. However both direct stress damage and indirect cavitation erosion seem to be necessary to obtain eliminable fragments. In previous studies, Coleman et al. monitored cavitation in-vivo through the associated acoustic emissions. The objective of this research was to design a new diagnostic device for lithotripsy, exploiting the information carried by these acoustic emissions. After preliminary laboratory experiments some clinical prototypes were developed in collaboration with Precision Acoustic Ltd., UK. The prototypes are currently been tested in the clinic

    The 1998 Fedele F. and Iris M. Fauri Lecture, University of Michigan School of Social Work

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    The Fedele F. and Iris M. Fauri Lecture is presented annually in recognition of former University of Michigan Vice President and School of Social Work Dean Fedele F. Fauri and his wife, Iris. Dean Fauri's leadership in the field of child welfare spanned nearly 50 years, with much of the current social welfare legislation at both state and federal levels being a product of Dean Fauri's activities, first as director of the Michigan Department of Social Services, and then during his years in Washington, DC, where he held numerous leadership positions. His accomplishments in child welfare and social work education brought national and international acclaim to Dean Fauri, the School of Social Work, and the University of Michigan. This lecture series is funded by gifts from alumni, faculty, and friends, and is intended to serve as a forum for discussing ideas and proposals to enhance the well-being of young people.The Fedele F. and Iris M. Fauri Family; School of Social Work; alumni, faculty, and friends of the School of Social Workhttp://deepblue.lib.umich.edu/bitstream/2027.42/49502/3/1998 Fauri Lecture Csete.pd

    Ettore Fedele PhD thesis entitled ‘Genomic tools for great ape population dynamics and conservation’ - electronic appendices and additional files

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    Electronic appendices in Excel and textfile format to the PhD thesis entitled ‘Genomic tools for great ape population dynamics and conservation’ by Ettore Fedele, University of Leicester: ·  Appendix A Amplification_behaviour_of_loci_included_in_the_multiplex  ·  Appendix B aSTR_Sequences  ·  Appendix C XSTR_Sequences  ·  Appendix D ForensicStats_ForenSeq_data  ·  Appendix E SNP_&_MicroHap_Calling_Scripts  ·  Appendix F SNP_&_MicroHap_codes  ·  Appendix G ii_&_si_SNP_genotypes  ·  Appendix H Microhaplotype_sequences  ·  Appendix I IdentityAnalysis_Gbb  ·  Appendix J IdentityAnalysis_Gbg  ·  Appendix K IdentityAnalysis_Gbb  ·  Appendix L Microhaplotype_STURCTURE_K_2  ·  Appendix M MLRelate_Gbb_SNPs_&_MicroHaps  ·  Appendix N MLRelate_Gbg_SNPs_&_MicroHaps  ·  Appendix O MLRelate_Ggg_SNPs_&_MicroHaps ·  Additional file 1: Fedele_FDSToolsOutput ·  Additional file 2: Pan_FDSTools_InputLibrary ·  Additional file 3: Gorilla_FDSTools_InputLibrary</p

    The 2000 Fedele F. and Iris M. Fauri Lecture, University of Michigan School of Social Work

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    The Fedele F. and Iris M. Fauri Lecture is presented annually in recognition of former University of Michigan Vice President and School of Social Work Dean Fedele F. Fauri and his wife, Iris. Dean Fauri's leadership in the field of child welfare spanned nearly 50 years, with much of the current social welfare legislation at both state and federal levels being a product of Dean Fauri's activities, first as director of the Michigan Department of Social Services, and then during his years in Washington, DC, where he held numerous leadership positions. His accomplishments in child welfare and social work education brought national and international acclaim to Dean Fauri, the School of Social Work, and the University of Michigan. This lecture series is funded by gifts from alumni, faculty, and friends, and is intended to serve as a forum for discussing ideas and proposals to enhance the well-being of young people.The Fedele F. and Iris M. Fauri Family; School of Social Work; alumni, faculty, and friends of the School of Social Workhttp://deepblue.lib.umich.edu/bitstream/2027.42/49500/3/2000 Fauri Lecture Rosenbaum.pd

    The 2007 Fedele F. and Iris M. Fauri Lecture, University of Michigan School of Social Work

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    The Fedele F. and Iris M. Fauri Lecture is presented annually in recognition of former University of Michigan Vice President and School of Social Work Dean Fedele F. Fauri and his wife, Iris. Dean Fauri's leadership in the field of child welfare spanned nearly 50 years, with much of the current social welfare legislation at both state and federal levels being a product of Dean Fauri's activities, first as director of the Michigan Department of Social Services, and then during his years in Washington, DC, where he held numerous leadership positions. His accomplishments in child welfare and social work education brought national and international acclaim to Dean Fauri, the School of Social Work, and the University of Michigan. This lecture series is funded by gifts from alumni, faculty, and friends, and is intended to serve as a forum for discussing ideas and proposals to enhance the well-being of young people.The Fedele F. and Iris M. Fauri Family; School of Social Work; alumni, faculty, and friends of the School of Social Workhttp://deepblue.lib.umich.edu/bitstream/2027.42/57736/1/2007 Fauri Lecture Markel.pd

    The 2008 Fedele F. and Iris M. Fauri Lecture, University of Michigan School of Social Work

    No full text
    The Fedele F. and Iris M. Fauri Lecture is presented annually in recognition of former University of Michigan Vice President and School of Social Work Dean Fedele F. Fauri and his wife, Iris. Dean Fauri's leadership in the field of child welfare spanned nearly 50 years, with much of the current social welfare legislation at both state and federal levels being a product of Dean Fauri's activities, first as director of the Michigan Department of Social Services, and then during his years in Washington, DC, where he held numerous leadership positions. His accomplishments in child welfare and social work education brought national and international acclaim to Dean Fauri, the School of Social Work, and the University of Michigan. This lecture series is funded by gifts from alumni, faculty, and friends, and is intended to serve as a forum for discussing ideas and proposals to enhance the well-being of young people.The Fedele F. and Iris M. Fauri Family; School of Social Work; alumni, faculty, and friends of the School of Social Workhttp://deepblue.lib.umich.edu/bitstream/2027.42/61848/1/2008_Fauri_Lecture_Freed.pd

    The 2006 Fedele F. and Iris M. Fauri Lecture, University of Michigan School of Social Work

    No full text
    The Fedele F. and Iris M. Fauri Lecture is presented annually in recognition of former University of Michigan Vice President and School of Social Work Dean Fedele F. Fauri and his wife, Iris. Dean Fauri's leadership in the field of child welfare spanned nearly 50 years, with much of the current social welfare legislation at both state and federal levels being a product of Dean Fauri's activities, first as director of the Michigan Department of Social Services, and then during his years in Washington, DC, where he held numerous leadership positions. His accomplishments in child welfare and social work education brought national and international acclaim to Dean Fauri, the School of Social Work, and the University of Michigan. This lecture series is funded by gifts from alumni, faculty, and friends, and is intended to serve as a forum for discussing ideas and proposals to enhance the well-being of young people.The Fedele F. and Iris M. Fauri Family; School of Social Work; alumni, faculty, and friends of the School of Social Workhttp://deepblue.lib.umich.edu/bitstream/2027.42/57735/1/2006 Fauri Lecture Elders.pd
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