16,513 research outputs found
Historical Overview of Familial Gastric Cancer
No full textFamily history has contributed greatly to understanding inherited diseases throughout the centuries, in particular familial and hereditary cancer syndromes. To assess the cancer risk for unaffected members and to identify a possible genetic cause, it is important to describe a detailed family history, including information about life status, gender, age at onset, affected members and the number of generations. Therefore, a careful anamnesis focused on oncological data, could lead to the diagnosis of familial and/ or hereditary cancer. The defi nition of familial is a nonspecifi c status and indicates only a positive family history. Rather, the diagnosis of hereditary cancer has to be confi rmed by some specifi c genetic tests. Nevertheless, the fi rst step in this procedure is the collection of family information, one's history
Introduction, in S. Corso, F. Mussgnug, J. Rushworth, Dwelling on Grief. Narratives Across Time and Forms, Oxford: Legenda, 2022.
No full textMourning, as the experience of the pandemic reminds us, crosses the dividing lines between life and literature, and blurs any attempted opposition of the private and the familial versus the professional and the academic. This insight about the imbrication of life and writing is framed in the essays that follow. We suggest, with Jacques Derrida, that:
On ne peut pas tenir un discours sur le ‘travail du deuil’ sans y prendre part [...]. Il n’y a donc pas de métalangage quant au langage où s’engage un travail du deuil.
[One cannot hold a discourse on the ‘work of mourning’ without taking part in it [...]. There is thus no metalanguage for the language in which a work of mourning is at work.]
One of the connecting threads of our volume is this tension between consideration of discourses on mourning across different disciplines and fields — in particular, Comparative Literature, Modern Languages, English, Medieval Studies, Political Thought, Music, Biology and the Environmental Humanities — and an acknowledgement of the ways in which metalanguage breaks down and is punctuated by experience
Prophylactic Total Gastrectomy in CDH1 Germline Mutation Carriers
No full textGermline mutation of the CDH1 gene, which encodes for the E-cadherin adhesion protein, is rare but confers an estimated lifetime risk of hereditary diffuse gastric cancer higher than 80 %. Prophylactic total gastrectomy seems to eliminate the high risk of developing diffuse gastric cancer in patients with this mutation. Current guidelines propose an accurate pre-operative work-up to engage patients at risk who can be good candidates for prophylactic surgery. In this chapter we analyze the general indications to prophylactic total gastrectomy and the diagnostic and therapeutic work-up, with particular reference to the techniques most used and recommended. We also investigate the metabolic consequences of a total gastrectomy and its impact on the patient's quality of life, together with the possible complications can be caused by this kind of operation
Studi sul caporalato
No full textIl volume vuole essere un approccio interdisciplinare ad un settore, quello della intermediazione illecita e dello sfruttamento del lavoro, dove - con la legge n. 199/2016 - si coglie la nitida consapevolezza delle ricadute della giustizia sull'economia e della necessità di operare in modo che la responsabilità penale o amministrativa rimanga circoscritta alle persone fisiche o giuridiche cui l’illecito è attribuibile. Il diffuso lavoro sommerso, la persistente crisi economica, l'ingresso della criminalità organizzata nella gestione di gruppi vulnerabili hanno portato a conoscere la figura del caporale anche in settori diversi da quello agricolo, trasformandola in componente dell'organizzazione criminale
Clinical Management of Familial Gastric Cancer
No full textThe clinical management of familial gastric carcinoma requires a multidisciplinary counsel. In this chapter we discuss about the hereditary diffuse gastric cancer surveillance and other minor genetic diseases as the hereditary nonpolyposis colorectal cancer, Li-Fraumeni syndrome, and Peutz-Jeghers syndrome. Moreover we proposed an algorithm for the clinical management of familial intestinal gastric tumors, in which genetic test is not applicable
The Family Cancer Database
No full textFamily history's collection is an important step to evaluate the risk accuracy for asymptomatic members. Clinical data can be archived carefully in a family databases; a complete cancer archive requires the record of several information. Pedigree's design is necessary to approach at proband with a suspicious hereditary cancer. We develop an interactive family cancer database, with a large series of patients affected by primary gastric cancer including also a control population (cancer free). All data are stored in a set of tables, recorded in Microsoft Access. Aim of this archive is to identify individuals with family cancer history, and to manage asymptomatic members
ASO Author Reflections: Is Breast-Conserving Surgery a Safe Treatment Option for High-Risk Breast Cancer?
No full textGastric Cancer in Other Inherited Syndromes
No full textCDH1 germline mutation is the most important genetic mechanism that associates with the development of the hereditary diffuse gastric cancer syndrome. However, gastric carcinoma participates also in other inherited predispositions as the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz Jeghers syndromes. While in these cases the gastric cancer risk is undefined and causative germline mutations are rarely identified, members of the family can be similarly tested and identified, providing targeted surveillance and management opportunities
Frequency of Familial Gastric Cancer
No full textAbout 80–90 % of gastric cancer appears as sporadic form, and 10–20 % with a familial setting; however, considering the different worldwide countries, this frequency appears extremely variable. In high risk-area for gastric tumors this incidence results higher than in low-risk zones. Conversely, the frequency of CDH1 germline mutations is contrasting with the incidence of familial gastric carcinoma. Exploring these considerations, in high-risk area it seems that environmental factors exercise a stronger mechanism in the familial gastric carcinogenesis. This data could open new approaches in the gastric cancer prevention test; before to candidate a proband for the CDH1 genetic screening, geographic variability, alongside the family history should be considered
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