168 research outputs found
Philippe Carrer. - Oedipe en Bretagne. Essai d'ethnopsychiatrie. Privat. 1986. Ph. Carrer, Y Daumer, P. Denez, J. Kress, F. Elegoet, P. Violette. - Permanence de la langue bretonne ; de la linguistique à la psychanalyse. Institut culturel de Bretagne. 1986 Ph. Carrer, D. Houzel, Gw. Le Bechennec, N. Meyer, Cl. Vedeilhie, P. Violette. L'enfant breton et ses images parentales ; études ethno-psychologiques. Institut culturel de Bretagne. 1987
No full textCastelain Jean-Pierre. Philippe Carrer. - Oedipe en Bretagne. Essai d'ethnopsychiatrie. Privat. 1986. Ph. Carrer, Y Daumer, P. Denez, J. Kress, F. Elegoet, P. Violette. - Permanence de la langue bretonne ; de la linguistique à la psychanalyse. Institut culturel de Bretagne. 1986 Ph. Carrer, D. Houzel, Gw. Le Bechennec, N. Meyer, Cl. Vedeilhie, P. Violette. L'enfant breton et ses images parentales ; études ethno-psychologiques. Institut culturel de Bretagne. 1987. In: Cahiers de sociologie économique et culturelle, n°7, 1987. pp. 170-171
Luisa Lateau de Bois d'Haine : su vida, su éxtasis, sus estigmas : estudio médico
Get PDFCopia digital. España : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, d2024Rústica.Registro de la Propiedad Intelectual: Ley de 1847: 17285; n. de solicitud de ingreso: "4713"; fecha y datos de ingreso: "Madrid 3 de Enero 1876", "Reg.do fº 254 libº 26"; firma del depositante: "C. Castelain
Simeprevir for the treatment of hepatitis C virus infection
No full textLaure Izquierdo,1 François Helle,1 Catherine François,1,2 Sandrine Castelain,1,2 Gilles Duverlie,1,2 Etienne Brochot1,2 1Virology Research Unit, Jules Verne University of Picardie, 2Department of Virology, Amiens University Hospital, Amiens, France Abstract: Simeprevir (TMC435, Olysio™), a second-generation hepatitis C virus (HCV) protease inhibitor, has been recently approved for the treatment of genotype 1 chronic hepatitis C in combination with pegylated interferon and ribavirin. This molecule has very different characteristics from first-generation protease inhibitors. Results from trials show that simeprevir is highly effective and safe, with few adverse events. We discuss the specific features of this new treatment option for HCV infection, in terms of in vitro data, pharmacological data, and clinical trials. We also discuss the impact of Q80K polymorphism at baseline. Studies evaluating interferon-free regimens with simeprevir are ongoing. Future combinations of two or more direct-acting antiviral agents, targeting different viral enzymes and with synergistic antiviral effects, will be approved, allowing treatment of pan-genotypic HCV with optimized sustained virologic responses. Simeprevir will undoubtedly be part of future treatment strategies. Keywords: simeprevir, protease inhibitor, direct-acting antiviral agent, hepatitis C viru
Health risk due to fluorides, nitrates and arsenic in groundwater: the case of the city of Tres Arroyos, Argentina
No full textMuestreos de calidad del agua de pozos someros de la ciudad de Tres Arroyos, Argentina, arrojaron la presencia simultánea de fluoruros, nitratos y arsénico (F-, NO3- y As) en concentraciones variables. Se analizó el riesgo a la salud por la presencia de esas sustancias verificando si existen diferencias entre distintos puntos de la ciudad, escenarios de exposición y diferentes tipos de individuos expuestos. El análisis se realizó utilizando el modelo básico de análisis de riesgo sanitario probabilístico de la agencia de protección ambiental de los Estados Unidos de América (USEPA 1989) considerando tres estratos de edades infantiles (5, 10 y 15 años) e integrando escenarios de tipo residencial con escolar, sobre la base de la exposición por la ingesta y por el contacto dérmico con el agua. Los niveles de riesgo, en general, sobrepasan el nivel de seguridad, salvo en el caso del contacto dérmico. Los valores del riesgo integrado (riesgo residencial + riesgo escolar) son decrecientes con relación a la edad y el principal contribuyente al riesgo acumulado es el As. Se identificó la zona de la ciudad más desfavorable en cuanto a la situación de riesgo y se identificaron las ventajas que ofrecen los análisis de riesgo acumulativos y agregados.Water quality sampling of shallow wells in the city of Tres Arroyos, Argentina, showed the simultaneous presence of fluorides, nitrates and arsenic (F-, NO3- and As) in varying concentrations. We analyzed the health risk by the presence of these substances by checking whether there are differences between different parts of the city, exposure scenarios and different types of exposed individuals. The analysis was performed using the basic model of probabilistic health risk analysis of USEPA (1989) considering three children aged strata (5, 10 and 15) and integrating the residential and school scenarios on the basis of the exposition by ingestion and dermal contact with water. The risk levels generally exceed the level of security, except in the case of skin contact. Integrated risk values (residential risk + school risk) are decreasing with respect to age and the main contributor to the cumulative risk is As. We identified the the worst area of the city in terms of risk and identified the advantages of cumulative and aggregate risk analysis.Fil: Othax, Natalia Elisabet. Universidad Nacional del Centro de la Provincia de Buenos Aires. Rectorado. Instituto de Hidrología de Llanuras-Sede Azul. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto de Hidrología de Llanuras-Sede Azul; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Peluso, Fabio Oscar. Universidad Nacional del Centro de la Provincia de Buenos Aires. Rectorado. Instituto de Hidrología de Llanuras-Sede Azul. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto de Hidrología de Llanuras-Sede Azul; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: González Castelain, José. Universidad Nacional del Centro de la Provincia de Buenos Aires. Rectorado. Instituto de Hidrología de Llanuras-Sede Azul. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto de Hidrología de Llanuras-Sede Azul; Argentin
Bacteria involved in 128 septic foals and their antimicrobial resistance
No full textAbstract: Bacteria involved in 128 septic foals and their antimicrobial resistance
D. Castelain, A. Dufourni, E. Paulussen, L. Lefère, F. Boyen, G. van Loon, B. Pardon
Introduction: Knowledge of causative bacteria and their susceptibility patterns in septic foals is crucial for starting early and appropriate antimicrobial therapy to increase survival rates. Aim of the study was to identify bacterial isolates obtained from septic foals and to determine their antimicrobial susceptibility profile.
Methods: Retrospective study. A total of 299 foals suspected of sepsis aged up to two months admitted to the internal medicine department of a university hospital from 2013 to 2021. Bacteria were identified from blood cultures (Bactec) using biochemical testing or MALDI-TOF MS, while disk diffusion method was performed for antimicrobial susceptibility testing.
Results: Of 299 foals, 42.8%(128/299) tested blood culture positive whereof 101 bacterial isolates were identified. In total, 58.4%(59/101) isolates were Gram-negative whereas 41.6%(42/101) were Gram-positive. In 12.9%(13/101) cultures, two bacteria were isolated. Commonly isolated bacteria were Escherichia coli (E. coli) 17.8%(18/101), Actinobacillus equuli 11.9%(12/101) and Staphylococcus spp. 19.8%(20/101), including S. equorum, S. aureus, S. sciuri, S. vitulinus, S. lentus and S. xylosus. Enterobacteriaceae other than E. coli 9.9%(10/101), including Klebsiella pneumoniae 4.0%(4/101), Salmonella 3.0%(3/101) and Enterobacter cloacae 3.0%(3/101) were also frequently observed in this population. Two of the Staphylococcus isolates were suspected to be methicillin resistant, while four isolates, E. coli, Klebsiella pneumoniae (2) and Enterobacter cloacae, showed phenotypic characteristics suggesting presence of an extended spectrum beta lactamase.
In general, antimicrobial resistance in Enterobacteriaceae was highly prevalent, with resistance percentages of 50.0%(7/14) for E. coli against tetracyclines, 42.9%(6/14) against aminopenicillins and potentiated sulphonamides, while 80%(8/10) of Enterobacteriaceae other than E. coli were resistant against aminopenicillins and potentiated sulphonamides. In contrast, Staphylococcus spp. showed seldom antimicrobial resistance.
Discussion: In this population of septic foals, Gram-negative bacteria were isolated most frequently.
Clinical relevance: Knowledge on frequently isolated bacteria and their antimicrobial susceptibility profile will help clinicians in future decision-making when starting early antimicrobial treatment
Designing bioactive surfaces to struggle biofouling
No full textLe biofouling est une accumulation d'organismes sur des surfaces naturelles ou artificielles, ce qui entraîne des inconvénients majeurs dans la plupart des cas. Il est également appelé biofilm au stade primaire. Ce biofilm, principalement composé de communautés de microorganismes, débute par une adsorption de macromolécules (par exemple :protéine, lipide) en tant que film primaire conditionnant. Pour lutter contre ce problème et mieux comprendre le mécanisme de l'adhésion microbienne, différents types de surfaces sont proposés pour évaluer leurs propriétés adhésives dans une chambre à écoulement cisaillé. Il s’agit de:i) revêtements en couche mince de dioxyde de titane (TiO2), d'oxyde d'aluminium (Al2O3) et de parylène C sur de la silice fondue (f-SiO2) en utilisant la méthode de dépôt chimique en phase vapeur (CVD)ii) fonctionnalisation bioactive qui consiste à immobiliser une protéine, la subtilisine, sur un substrat de silice fondue en utilisant un procédé de réticulation.iii) matériaux composites constitués d’une matrice de polythiouréthane (PTU) contenant soit des particules sphériques d'oxyde de zinc (s-ZnO), soit des particules tétrapodales d'oxyde de zinc (t-ZnO) à diverses concentrations massiquesPour les revêtements en couche mince, notre intérêt se concentre sur leurs caractéristiques physico-chimiques de surface qui influencent le développement du film conditionnant et l'adhésion microbienne qui en résulte (modélisée par deux types de microbilles de polystyrène fonctionnalisées), tandis que la silice fondue nue est utilisée comme contrôle. Parmi la rugosité, l'hydrophobicité et le potentiel zêta de la surface, l'hydrophobicité est considérée comme le facteur déterminant de l'adhésion microbienne par l'analyse en composantes principales (ACP), suivie par la rugosité, alors que le potentiel zêta (mesure globale de la charge de surface) apparaît plus faiblement corrélé. Cependant, la distribution électronique qui résulte de la nature des liaisons des matériaux considérés doit influencer localement la façon dont la protéine s’adsorbe (nature de la liaison crée avec la surface, conformation de la protéine et donc encombrement stérique) et affecter ainsi l’adhésion microbienne qui s’ensuit. Selon la nature de la surface (et donc des liaisons) la présence du film conditionnant a une influence différente : elle augmente drastiquement l’adhésion des microbilles sur silice fondue mais pas sur les revêtements en couches minces. Cette influence de la distribution locale des charges est une possible explication à l’adhésion systématiquement plus forte des billes chargées négativement.Pour la fonctionnalisation bioactive, les impacts de la subtilisine immobilisée sur l'adsorption des protéines et l'adhésion microbienne (en utilisant des microbilles et le phénotype hydrophile de la levure Saccharomyces cerevisiae) sont également étudiés. Les résultats montrent que la subtilisine est capable d'empêcher l'adsorption des protéines puis l’adhésion microbienne, mais n'influence pas la propriété adhésive de la surface du substrat. Il est également important de noter que les cellules hydrophiles présentent une adhésion généralement plus faible que les microbilles hydrophobes, ce qui souligne le rôle crucial de la réaction hydrophobe dans l'adhésion microbienne.Enfin, pour les matériaux composites aussi bien que le PTU pur (en comparaison avec une surface modèle de PDMS) une diminution significative de l’adhesion microbienne a été observée, tant à l’échelle de la cellule par microscopie à force atomique sur deux souches pathogènes, qu’à celle d’une population en chambre à écoulement cisaillée sur des microbilles. Cette tendance est d’autant plus forte que la concentration de particules de ZnO de morphologie tétrapode est élevée.Biofouling is a ubiquitous accumulation of organisms on natural or artificial surfaces, which leads to unexpected disadvantages in most cases. It is also named biofilm in the pre-mature stage, mainly composed with microorganism communities in presence of previous macromolecule adsorption (e.g., protein, lipid) as conditioning film. To struggle this issue and better understand the mechanism of microbial adhesion, different types of surface are proposed to evaluate their adhesion properties using shear-stress flow chamber in this manuscript, including:i) thin film deposition of titanium dioxide (TiO2), aluminum oxide (Al2O3) and parylene C on fused silica (f-SiO2) using chemical vapor deposition (CVD) methodii) bioactive functionalisation as subtilisin-immobilized fused silica using cross-linking methodiii) composite materials of polythiourethane (PTU) matrix containing either spherical zinc oxide (s-ZnO) particles or tetrapodal zinc oxide (t-ZnO) particles in various concentrations as fillersFor thin coatings, our interest focusses on in what extent their surface physicochemical characteristics influence the growth of conditioning film and subsequent microbial adhesion (modelled by two types of functionalized polystyrene microbeads), where bare fused silica was applied as control. Among surface roughness, surface hydrophobicity and surface zeta potential, the hydrophobicity is considered as the driving factor for microbial adhesion through Principal Component Analysis (PCA), followed by the roughness, whereas the zeta potential appears less correlated. However, the surface charge distribution resulted from the nature of chemical bonds in each material may contribute to the variation of adsorption behaviours and probably alter the protein conformation on the surface. Thus, the protein composed conditioning film affects the later microbial adhesion differently, where extra iono-covalent bonds provided by protein lead to a significant increase of microbial adhesion on originally covalent fused silica but not on thin film coatings. This also explains the more stable adhesion of negatively charged microbeads.For bioactive functionalisation, the impact of immobilized subtilisin on protein adsorption and microbial adhesion (using microbeads and hydrophilic phenotype of yeast Saccharomyces cerevisiae) are both studied. The results indicate that subtilisin prevents from protein adsorption and subsequent enhanced microbial adhesion. Additionally, a control experiment shows that the immobilized enzyme did not alter the surface properties of the substrate. It is also important to note that hydrophilic cells exhibit a generally weaker adhesion than hydrophobic microbeads, which emphasizes the crucial role of hydrophobic reaction in microbial adhesion.For both composite materials and pure PTU a significant reduction of the adhesion of microorganisms in single cell level compared to polydimethylsiloxane (PDMS) was observed. The reduction was more pronounced with a higher concentration of fillers, particularly in the case of 5 wt.% t-ZnO (tetrapodal morphology). Within the PTU variations, such reduction was also observed in the population level with polystyrene microbeads
Heterogeneous Extractive Batch Distillation of Chloroform - Methanol – Water : Feasibility and Experiments
Get PDFA novel heterogeneous extractive distillation process is considered for separating the azeotropic mixture chloroform – methanol in a batch rectifying column, including for the first time an experimental validation of the process. Heterogeneous heavy entrainer water is selected inducing an unstable ternary heteroazeotrope and a saddle binary heteroazeotrope with chloroform (ternary diagram class 2.1-2b). Unlike to well-known heterogeneous azeotropic distillation process and thanks to continuous water feeding at the column top, the saddle binary heteroazeotrope chloroform – water is obtained at the column top, condensed and further split into the liquid – liquid decanter where the chloroform-rich phase is drawn as distillate. First, feasibility analysis is carried out by using a simplified differential model in the extractive section for determining the proper range of the entrainer flowrate and the reflux ratio. The operating conditions and reflux policy are validated by rigorous simulation with ProSim Batch Column® where technical features of a bench scale distillation column have been described. Six reproducible experiments are run in the bench scale column matching the simulated operating conditions with two sequentially increasing reflux ratio values. Simulation and experiments agree well. With an average molar purity higher than 99%, more than 85% of recovery yield was obtained for chloroform and methanol
Numerical Simulation and Models for Microcoaxial Probes. Application to "In Vivo" Measurements of Dielectric Parameters of Biological Media in the Microwave Band (1-12 GHz)
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