1,721,156 research outputs found
Development of a novel approach to overcome biofilm formation by natural product derivatives
No full textWith the aim to prevent biofilm formation, and based on our previous studies, 1, 2 we explored new strategies
involving inorganic nanoparticles for surface covering. In detail, we investigated the functionalization of silica
nanoparticles with natural derivatives showing anti-biofilm properties, using linkers of different nature and
length. After their analytical characterization, the new derivatives were used to obtain glass coverslips by spin-coating technology for the biological testing (Figure 1). The promising results towards E. coli and P.
aeruginosa will be presented.
1 C. Cattò; S. Dell'Orto; F. Villa; S. Villa; A. Gelain; A. Vitali; V. Marzano; S. Baroni S; F. Forlani; F. Cappitelli. PLoS ONE 2015, 10(7), e0131519.
2 C. Cattò; G. Grazioso; S. Dell’Orto; A. Gelain; S. Villa, V. Marzano; A. Vitali; F. Villa; F. Cappitelli; F. Forlani. Biofouling 2017, 33, 235-25
Il progetto Anfomat: Novel materials for medical devices based on biofunctionalized surfaces with antifouling properties
No full textUn vasto numero di dispositivi medici sono stati visti ospitare biofilm, comunità microbiche adese a superfici inglobate in una matrice polimerica, che possono portare ad infezioni.
Le infezioni vengono comunemente trattate con alte dosi di antibiotici o la sostituzione del dispositivo. I risultati non sono sempre positivi, ad esempio per il rischio di sviluppare resistenza nei confronti degli antibiotici usati.
Nel progetto ANFOMAT, che ha visto il contributo di Fondazione Cariplo, molecole naturali capaci di interferire a dosi sub-letali con la formazione del biofilm ed enzimi idrolitici capaci di degradare la matrice del biofilm sono stati legati ai polimeri di dispositivi medici.
Il prodotto della ricerca ANFOMAT sono quindi materiali biofunzionalizzati utili per contrastare efficacemente la formazione del biofilm su dispositivi medici
THM-GCMS and FTIR for the study of binding media in Yellow Islands by Jackson Pollock and Break Point by Fiona Banner
No full textThroughout the 20th century a number of binding media, including synthetic resins, have been employed in paints. It is only very recently that thermally assisted hydrolysis and methylation-gas
chromatography-mass spectrometry (THM-GCMS) has been used for the identification of a wide
variety of binding media employed in the 20th century art. This paper shows as THM-GCMS was
successfully used in conjunction with FourierTransform Infrared Spectroscopy for the study of binding
media in samples from Yellow Islands by Jackson Pollock [Tate Collection, T00436] and Break Point by Fiona Banner [Tate Collection, T07501]
Chemical–physical and aerobiological Measurements for Indoor Air Quality Assessment at the Ca’ Granda Historical Archive, Milan (Italy)
No full text
Mini-review : biofilm responses to oxidative stress
No full textBiofilms constitute the predominant microbial style of life in natural and engineered ecosystems. Facing harsh environmental conditions, microorganisms accumulate reactive oxygen species (ROS), potentially encountering a dangerous condition called oxidative stress. While high levels of oxidative stress are toxic, low levels act as a cue, triggering bacteria to activate effective scavenging mechanisms or to shift metabolic pathways. Although a complex and fragmentary picture results from current knowledge of the pathways activated in response to oxidative stress, three main responses are shown to be central: the existence of common regulators, the production of extracellular polymeric substances, and biofilm heterogeneity. An investigation into the mechanisms activated by biofilms in response to different oxidative stress levels could have important consequences from ecological and economic points of view, and could be exploited to propose alternative strategies to control microbial virulence and deterioration
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