4,039 research outputs found
Excitation functions of residues in the interaction of C-12 with Rh-103 up to an incident energy of 400 MeV
No full textThe excitation functions for production of 45 residues in the interaction of C-12 with Rh-103 at incident energies ranging from about 40 to 400 MeV are analysed in terms of many competing reaction mechanisms including complete and incomplete fusion reactions and the quite relevant contribution of the decay of the target nucleus excited in the inelastic scattering of the incident C-12 ions. The cross-sections of most of these mechanisms have been obtained by extrapolation from the values measured in the interaction of C-12 with the neighbouring nucleus Nb-93. The agreement between experimental data and model predictions is very good in most cases. (c) 2005 Elsevier B.V. All rights reserved
Detection of single and resonant projectile fragments in C-12-induced reactions to the continuum
No full textDetector telescopes having a DeltaE-E configuration, consisting of either a Si surface barrier detector or a Si strip detector followed by a NaI(Tl) stopping detector, are described for measuring intermediate mass fragments in C-12-induced reactions to the continuum. These include the stable break-up fragments Be-7 and Be-9, as well as the resonant fragment Be-8. Energy calibration of the stopping detectors is based on a scintillation light-response model. Empirical approximating functions have been selected for inverting the theoretical functions relating light output to particle energy, in order to achieve calibration during rapid data sorting. The detector efficiency for resonant fragments is obtained by means of a Monte Carlo simulation. A dedicated eight-channel preamplifier module with good operational stability in vacuum, specifically designed for Si-strip detectors, is also described
Geneva C. Cessna Lanphere Scrapbook
No full textThese items are images from digital and paper sources that were gathered for the Toledo Women Lawyers History Project (TWLHP). The material in this folder focuses on the career of Geneva C. Cessna Lanphere (1904-1976). She is first listed as an attorney in Toledo the 1932 City Directory, and the following year she is listed with a partner, Geraldine F. Connell. She is also listed as the Assistant Director of the City Department of Law in 1933. She continued to practice at the beginning of her marriage; she is still listed as a partner with Connell in 1934, with the last name of Lanphere. At the time of her death in 1976, she was living in Pennsylvania. Images in this folder include a portrait, yearbook page and directory listings
Establishment of hedgehog pathway overexpression in osteosarcoma cell lines leading to an anti-apoptotic genotype which can be inhibited by the common anti-fungal and hedgehog pathway inhibitor, itraconazole
No full textOsteosarcoma (OS) is the most common primary bone cancer in dogs, yet therapies for pets with metastatic OS remain clinically ineffective. With the advent of precision medicine, strong scientific and clinical impetus exists to further investigate druggable molecular perturbations that might contribute to canine OS pathology. Dysregulated activity of the hedgehog (HH) pathway has been identified in diverse cancers in people and animals and leads to overexpression of anti-apoptotic proteins including Bcl-2 and c-FLIP. This produces an anti-apoptotic genotype by influencing both the intrinsic and extrinsic arms of the apoptotic pathway. Itraconazole is an antifungal agent that has been found to inhibit Smoothened (SMO), a crucial G protein-coupled receptor located on the cell membrane and becomes activated on the primary cilium, which allows initiation of HH pathway signaling. We hypothesize that components of the HH pathway are overexpressed in canine OS cell lines with concurrent downstream anti-apoptotic factor overexpression relative to non-malignant osteoblasts. Additionally, itraconazole would inhibit HH pathway signaling by promoting SMO relocation off the primary cilium.
RNA transcript and protein expressions of SMO, Bcl-2 and c-FLIP were characterized in three canine OS cell lines and normal canine osteoblast cultures. The IC50 concentrations of itraconazole in OS cell lines were determined, and itraconazole’s effects on the HH pathway signaling partners were evaluated at RNA and protein levels. Confocal microscopy was utilized to confirm the modulation of protein levels after treatment with itraconazole. In addition, the effect of the combinations of itraconazole and commonly used cytotoxic agents, doxorubicin and carboplatin, were explored with regard to cell death. This data was used to assess the tolerability of itraconazole in combination with these chemotherapeutics in a murine model which was then used to explore the effects of itraconazole with or without cytotoxic agents on a metastatic osteosarcoma model.
OS cell lines overexpress SMO, Bcl-2, and c-FLIP relative to normal osteoblasts. The IC50 of itraconazole in OS cells ranged from 490-790 nM. Itraconazole effectively perturbs protein expressions of the HH signaling pathway and downstream targets. The combination of itraconazole with carboplatin and itraconazole with doxorubicin was found to be synergistic compared to agents alone with regard to cell death. The combination of cytotoxin and itraconazole was found to be tolerable in mice with no cumulative toxicity.
SMO and Bcl-2 are overexpressed in OS cells and itraconazole can disrupt the HH signaling pathway at biologically relevant concentrations, warranting further investigation of itraconazole as adjuvant therapy for OS.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01The student, Dana Connell, accepted the attached license on 2020-11-02 at 19:08.The student, Dana Connell, submitted this Thesis for approval on 2020-11-02 at 20:00.This Thesis was approved for publication on 2020-11-18 at 12:01.DSpace SAF Submission Ingestion Package generated from Vireo submission #15854 on 2021-09-16 at 17:01:23Made available in DSpace on 2021-09-17T02:34:08Z (GMT). No. of bitstreams: 2
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Previous issue date: 2020-11-18Embargo set by: Seth Robbins for item 118456
Lift date: 2023-09-17T02:34:57Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Onl
Production of He-3 and He-6 fragments in the interaction of C-12 with Nb-93 at 400 MeV
No full textSpectra of inclusive double differential cross sections of He-3 and He-6 fragments produced in the interaction of C-12 with Nb-93 at 400 MeV are measured and analyzed. As was found for the production of intermediate mass fragments in this and similar reactions involving light projectiles, the spectra can to a large extent be satisfactorily reproduced only by considering the contribution of projectile break-up as well as nucleon coalescence. (c) 2005 Elsevier B.V. All rights reserved
Incomplete fusion of projectile fragments in the interaction of 12C with 103Rh up to 33 MeV per nucleon
No full textThe excitation functions of heavy residues produced in the interaction of12C with103Rh have been re-analysed theoretically by taking various competing reaction mechanisms into account. An initial-state dissipative interaction between the projectile and the target nucleus as well as the incomplete fusion of non-α-type fragments has been added to the analysis
Emission of intermediate mass fragments in the interaction of 16O with 59Co, 93Nb and 197Au
No full textIn this paper we study the emission of 8Begs, B and N fragments in the interaction of 16O ions
with 59Co, 93Nb and 197Au at incident energies varying from 6 to 25 MeV/nucleon. The spectra of these
fragments, as well as those of C fragments studied in a previous paper, are dominated at forward angles by
a component originating from break-up of 16O. At the higher incident energies break-up occurs after quite
a sizeable projectile energy loss. Another mechanism which dominates at large emission angles, favours
the emission of low-energy fragments and is attributed to the coalescence of nucleons during the cascade
of nucleon-nucleon interactions by means of which the excited nuclei produced in the primary two-ion
interaction thermalize
High-prevalence and high-estimated incidence of HIV infection among new injecting drug users in Estonia: need for large scale prevention programs.
No full textOBJECTIVE: To examine HIV risk behavior and HIV infection among new injectors in Tallinn, Estonia. Design and methods Data from two cross-sectional surveys of injecting drug users (IDUs) recruited from a syringe exchange program (N = 162, Study 1) or using respondent driven sampling (N = 350, Study 2). Behavioral surveys were administered; serum samples were collected for HIV testing. Subjects were categorized into new injectors (injecting 3 years). RESULTS: Twenty-eight of 161 (17%, Study 1) and 73/350 (21%, Study 2) of the study subjects were new injectors. HIV infection was substantial among the newer injectors: HIV prevalence was 50% (Study 1) and 34% (Study 2), and estimated HIV incidence 31/100 PY and 21/100 PY, respectively. In Study 2, new injectors were more likely to be female and ethnic Estonian and less likely to be injecting daily compared with long-term injectors. No significant difference was found among two groups on sharing injecting equipment or reported number of sexual partners. CONCLUSIONS: A continuing HIV epidemic among new injectors is of critical public health concern. Interventions to prevent initiation into injecting drug use and scaling up HIV prevention programs for IDUs in Estonia are of utmost importance
Angular distributions and forward recoil range distributions of residues created in the interaction of 12C and 16O with 103Rh
No full textWe have measured the angular distributions and the forward recoil range distributions of residues produced in the interaction of, respectively, 151, 228 and 402 MeV 12C ions with 103Rh and the forward recoil range distributions of residues produced in the interaction of 303 MeV 16O ions with 103Rh. These data have been successfully reproduced by a theory which assumes that the dominant mechanisms are complete and incomplete fusion of the projectile with the target and single nucleon transfers from the projectile to the target and predicts that, starting from an incident energy of about 250 MeV, a large fraction of the residues has a mass and charge very close to those of the target nucleus. This is because, at incident energies of a few hundred MeV, a large fraction of the kinetic energy of 12C and 16O is carried away by fast ejectiles which then leave behind the intermediate equilibrated nuclei with a rather small excitation energy and small forward linear momentum
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