184 research outputs found
Stadt-Theater Düsseldorf / Stein unter Steinen : ausser Abonnement ; Samstag, den 18. März 1916 ; Gastspiel von Albert Bassermann vom Lessingtheater Berlin ; Schauspiel in 4 Akten
No full textvon Hermann Sudermann. Spielleitung: Béla Duschak. Personen: Hans Werder, Franziska Wendt, Else Kittner, Arthur Schetter, Emil Wirth, Selma Wuttke, Kl. Agethen, O. F. Teuscher, Ludwig Mayr, Max Wogritsch, Robert Scholz, Otto Busch, Ernst Herz. Jakob Biegler: Albert Bassermann als Gas
Resultats scientifiques et pratiques destinés a la construction des machines
No full textContiene: T.I. Resultats scientifiques et pratiques destinés a la construction des machines, 1874 (XII, 533)-- T. II. Resultats scientifiques et pratiques destinés a la construction des machines : Atlas de 41 Planches, 1873 ([41]h.
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
No full textOne component of the circadian clock in mammals is the Clock-Bmal1 heterodimeric transcription factor. Among its downstream targets, two genes, Cry1 and Cry2, encode inhibitors of the Clock-Bmal1 complex that establish a negative-feedback loop. We found that both Cry1 and Cry2 proteins are ubiquitinated and degraded via the SCF(Fbxl3) ubiquitin ligase complex. This regulation by SCF(Fbxl3) is a prerequisite for the efficient and timely reactivation of Clock-Bmal1 and the consequent expression of Per1 and Per2, two regulators of the circadian clock that display tumor suppressor activity. Silencing of Fbxl3 produced no effect in Cry1-/-;Cry2-/- cells, which shows that Fbxl3 controls clock oscillations by mediating the degradation of CRY proteins
Künstlerlaunen : 33 Zeichnungen ; mit alten und neuen Gedichten / von H. Baisch, W. Diez, F. A. Kaulbach, Hugo Kauffmann, Br. Piglhein, Rud. Seitz ...
No full textKÜNSTLERLAUNEN : 33 ZEICHNUNGEN ; MIT ALTEN UND NEUEN GEDICHTEN / VON H. BAISCH, W. DIEZ, F. A. KAULBACH, HUGO KAUFFMANN, BR. PIGLHEIN, RUD. SEITZ ...
Künstlerlaunen : 33 Zeichnungen ; mit alten und neuen Gedichten / von H. Baisch, W. Diez, F. A. Kaulbach, Hugo Kauffmann, Br. Piglhein, Rud. Seitz ... (1)
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JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
No full textJHDM1B is an evolutionarily conserved and ubiquitously expressed member of the JHDM (JmjC-domain-containing his- tone demethylase) family1–3. Because it contains an F-box motif, this protein is also known as FBXL10 (ref. 4). With the use of a genome-wide RNAi screen, the JHDM1B worm orthologue (T26A5.5) was identified as a gene that regulates growth5. In the mouse, four independent screens have identified JHDM1B as a putative tumour suppressor by retroviral insertion analysis6–9. Here we identify human JHDM1B as a nucleolar protein and show that JHDM1B preferentially binds the transcribed region of ribosomal DNA to repress the transcription of ribosomal RNA genes. We also show that repression of ribosomal RNA genes by JHDM1B is dependent on its JmjC domain, which is necessary for the specific demethylation of trimethylated lysine 4 on histone H3 in the nucleolus. In agreement with the notion that ribosomal RNA synthesis and cell growth are coupled processes, we show a JmjC-domain-dependent negative effect of JHDM1B on cell size and cell proliferation. Because aberrant ribosome biogenesis and the disruption of epigenetic control mechanisms contribute to cellular transformation, these results, together with the low levels of JHDM1B expression found in aggressive brain tumours, suggest a role for JHDM1B in cancer development
Principes de la construction des organes des machines
No full textCoeditada en París Librairie Polytechnique de J. BaudryT. 1 : XIV, 459 p., 45 h. de lá
Das Dynamiden-System : Grundzüge Einer Mechanischen Physik; Mit Einer Lithographirten Tafel
No full textVon F. Redtenbacher ...Vorlageform des Erscheinungsvermerks: MANNHEIM. VERLAGSBUCHHANDLUNG VON FRIEDRICH BASSERMANN. 1857
Resultats scientifiques et pratiques destinés a la construction des machines
No full textAntepSignaturizado"Lith. V. L. Gersendörfer, Carlsruhe
Supply Chain Management in the Life Science Sector: Does Trust Play a Role?
No full textSupply chain management has emerged as cross functional, cross company concept to improve coordination of entire value chains through coordinated actions of all companies in the value chain. It has received a major push from the availability of Internet-based information and communication technologies. The conditions in certain sectors are favorable for a realization of chain wide supply chain management. In other sectors, however, conditions are more complex and companies and value chains still struggle to exploit the potentials from supply chain management, in particular when it comes to cross enterprise coordination. This paper takes a complex supply network as example and discusses improvement potentials from supply chain management and developments in their implementation as well as barriers to the realization of chain wide supply chain management.supply chain management, trust, life science sector, Agribusiness, Industrial Organization,
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