129 research outputs found
Mechanisms of post-prandial protein accretion in human skeletal muscle: insight from leucine and phenylalanine forearm kinetics.
No full textIF: 12.01
A simple remote nutritional screening tool and practical guidance for nutritional care in primary practice during the COVID-19 pandemic.
No full textChallenging periods like the COVID-19 pandemic require fast and efficient adaptations of the healthcare system. It is vital that every patient has access to nutritional care as a part of primary healthcare services, even if social distancing measures are adopted. Therefore, we propose a simple remote nutritional screening tool and practical guidance for nutritional care in primary practice, and their implementation into telemedicine processes and digital platforms suitable for healthcare providers. The acronym for the tool is R-MAPP, as for Remote - Malnutrition APP, while the tool will be available also as an app. This protocol consists of two simple validated clinical tools for identifying nutritional risk and loss of muscle mass and function -Malnutrition Universal Screening Tool ('MUST') and SARC-F (5-item questionnaire: Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls) - and additional practical guidance on nutritional interventions for family physicians
Effect of protic compounds on ethylene polymerization by Hf-Ti supported catalysts
No full textThe effect was investigated of the addition of different protic compounds, such as water, n-butanol, butanoic acid and methyl ethyl ketone, to triisobutylaluminium used as the cocatalyst for an Hf-Ti bimetallic catalyst supported on magnesium dichloride (Ti1.0Hf1.3Mg2.0Al0.85Cl12.45) in the polymerization of ethylene. All the above compounds show a similar behaviour by decreasing catalyst activity, increasing polymer molecular weight and narrowing polymer molecular weight distribution. Minor differences are observed in the end-group unsaturations. An attempt has been made to correlate these effects to the interaction of hafnium and titanium sites with the reaction products from AlR3 and the different protic compounds
Structural features of 4-methyl-1-pentene polymers prepared with different transition metal catalysts
No full textHomopolymerization of 4-methyl-1-pentene carried out in the presence of catalysts containing variable relative amounts of Ti, Hf and Mg indicates that molecular weight and stereoregularity can be varied to an appreciable extent depending on catalyst nature and composition. A distinct behaviour of the various catalytic systems is also observed during the copolymerization of 4-methyl-1-pentene with monoalkenes such as propylene, 1-butene and 1-hexene. These data are discussed by underlining the important role of the transition metal in determining the features of polyolefins materials
Unacylated ghrelin normalizes skeletal muscle oxidative stress and prevents muscle catabolism by enhancing tissue mitophagy in experimental chronic kidney disease
No full textUnacylated ghrelin (UnAG) may lower skeletal muscle oxidative stress, inflammation, and insulin resistance in lean and obese rodents. UnAG-induced autophagy activation may contribute to these effects, likely involving removal of dysfunctional mitochondria (mitophagy) and redox state maintenance. In chronic kidney disease (CKD) oxidative stress, inflammation and insulin resistance may negatively influence patient outcome by worsening nutritional state through muscle mass loss. Here we show in a 5/6 nephrectomy (Nx) CKD rat model that 4 d s.c. UnAG administration (200 μg twice a day) normalizes CKD-induced loss of gastrocnemius muscle mass and a cluster of high tissue mitochondrial reactive oxygen species generation, high proinflammatory cytokines, and low insulin signaling activation. Consistent with these results, human uremic serum enhanced mitochondrial reactive oxygen species generation and lowered insulin signaling activation in C2C12 myotubes while concomitant UnAG incubation completely prevented these effects. Importantly, UnAG enhanced muscle mitophagy in vivo and silencing RNA-mediated autophagy protein 5 silencing blocked UnAG activities in myotubes. UnAG therefore normalizes CKD-induced skeletal muscle oxidative stress, inflammation, and low insulin signaling as well as muscle loss. UnAG effects are mediated by autophagy activation at the mitochondrial level. UnAG administration and mitophagy activation are novel potential therapeutic strategies for skeletal muscle metabolic abnormalities and their negative clinical impact in CKD.-Gortan Cappellari, G., Semolic, A., Ruozi, G., Vinci, P., Guarnieri, G., Bortolotti, F., Barbetta, D., Zanetti, M., Giacca, M., Barazzoni, R. Unacylated ghrelin normalizes skeletal muscle oxidative stress and prevents muscle catabolism by enhancing tissue mitophagy in experimental chronic kidney disease
Procedimento per la polimerizzazione dell'etilene e per la copolimerizzazione dell'etilene con alfa-olefine e catalizzatore relativo
No full textComparative behaviour of Hafnium and Titanium catalysts in the a-olefins copolymerization
No full textSupported hafnium and titanium catalysts were prepared under the same conditions starting from the corresponding tetrakisbutanolates, which were supported on MgCl2 by reaction of a suspension of Hf/Mg catalyst with aluminum alkyl chlorides. The systems were employed in the copolymerization of 1-hexene with 4-methyl-1-pentene. The extent of polymerization, as well as the copolymer composition, sequence distribution, stereoregularity, and molecular weight were evaluated. The hafnium catalysts gave higher molecular weights and better isotactic stereoregularity but displayed lower activity than the titanium catalysts, but the co-monomer distributions were similar for the two systems. These results are discussed in terms of the number and type of active sites
Distinct behaviour of Ti and Hf supported catalysts in the polymerization of different monoalkenes
No full textMgCl2 supported Ti and Hf catalysts were comparatively tested with respect to the polymerization of differently shaped monoalkenes. The ratio between the average polymerization rates of Ti and Hf catalysts during the first 120 min (V(p)Ti/V(p)Hf) is 10 for ethylene, increases to 63 for propylene and returns to approximately 12-20 for higher or bulkier monoalkenes, suggesting a distinct shape selectivity of active sites
Polymerization of C2-C6 α-olefins in the presence of modified Ziegler-Natta catalysts based on Titanium halides and organoaluminum sulfates
No full text- …
