993 research outputs found

    Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry

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    Martinez-Selles, M., Almenar, L., Paniagua-Martin, M.J., Segovia, J., Delgado, J.F., Arizõn, J.M., Ayesta, A., Lage, E., Brossa, V., Manito, N., Pérez-Villa, F., Diaz-Molina, B., Rábago, G., Blasco-Peirõ, T., De La Fuente Galán, L., Pascual-Figal, D., Gonzalez-Vilchez, F

    Impact of short-term mechanical circulatory support with extracorporeal devices on postoperative outcomes after emergency heart transplantation: Data from a multi-institutional Spanish cohort

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    Funding for this study was supplied by the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness, through the Red de Investigación CardiovascularBarge-Caballero, E., Almenar-Bonet, L., Villa-Arranz, A., Pérez-Villa, F., Segovia-Cubero, J., Delgado-Jiménez, J., González-Vilchez, F., Manito-Lorite, N., De-La-Fuente-Galán, L., Brossa-Loidi, V., Lambert-Rodríguez, J.L., Pascual-Figal, D., Lage-Gallé, E., Arizón-Del-Prado, J.M., Sanz-Julve, M., Muñiz-García, J., Crespo-Leiro, M

    Convergent Disfocality and Nondisfocality Criteria for Second-Order Linear Differential Equations

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    Copyright © 2013 Pedro Almenar and Lucas Jódar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This paper presents a method to determine whether the second-order linear differential equation y(n) + q(x)y = 0 is either disfocal or nondisfocal in a fixed interval. The method is based on the recursive application of a linear operator to certain functions and yields upper and lower bounds for the distances between a zero and its adjacent critical points, which will be shown to converge to the exact values of such distances as the recursivity index grows.This work has been supported by the Spanish Ministry of Science and Innovation Project DPI2010-C02-01.Almenar, P.; Jódar Sánchez, LA. (2013). Convergent Disfocality and Nondisfocality Criteria for Second-Order Linear Differential Equations. Abstract and Applied Analysis. 2013:1-11. doi:10.1155/2013/987976S1112013Kwong, M. K. (1981). On Lyapunov’s inequality for disfocality. Journal of Mathematical Analysis and Applications, 83(2), 486-494. doi:10.1016/0022-247x(81)90137-2Kwong, M. K. (1999). Integral Inequalities for Second-Order Linear Oscillation. Mathematical Inequalities & Applications, (1), 55-71. doi:10.7153/mia-02-06Harris, B. . (1990). On an inequality of Lyapunov for disfocality. Journal of Mathematical Analysis and Applications, 146(2), 495-500. doi:10.1016/0022-247x(90)90319-bBrown, R. C., & Hinton, D. B. (1997). Proceedings of the American Mathematical Society, 125(04), 1123-1130. doi:10.1090/s0002-9939-97-03907-5Tipler, F. J. (1978). General relativity and conjugate ordinary differential equations. Journal of Differential Equations, 30(2), 165-174. doi:10.1016/0022-0396(78)90012-8Došlý, O. (1993). Conjugacy Criteria for Second Order Differential Equations. Rocky Mountain Journal of Mathematics, 23(3), 849-861. doi:10.1216/rmjm/1181072527Moore, R. (1955). The behavior of solutions of a linear differential equation of second order. Pacific Journal of Mathematics, 5(1), 125-145. doi:10.2140/pjm.1955.5.125Almenar, P., & Jódar, L. (2012). An upper bound for the distance between a zero and a critical point of a solution of a second order linear differential equation. Computers & Mathematics with Applications, 63(1), 310-317. doi:10.1016/j.camwa.2011.11.023Almenar, P., & Jódar, L. (2013). The Distribution of Zeroes and Critical Points of Solutions of a Second Order Half-Linear Differential Equation. Abstract and Applied Analysis, 2013, 1-6. doi:10.1155/2013/147192Bellman, R. (1943). The stability of solutions of linear differential equations. Duke Mathematical Journal, 10(4), 643-647. doi:10.1215/s0012-7094-43-01059-

    Spanish Heart Transplantation Registry (Adults). The 25th official report of the Spanish Society of Cardiology Working Group on Heart Failure and Heart Transplantation (1984-2013) [Registro Español de Trasplante Cardiaco (Adultos). XXV Informe Oficial de la Sección de Insuficiencia Cardiaca y Trasplante Cardiaco de la Sociedad Española de Cardiología (1984-2013)]

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    El Registro Español de Trasplante Cardiaco está parcialmente financiado por una beca no condicionada de Novartis.González-Vílchez, F., Gómez-Bueno, M., Almenar Bonet, L., Crespo-Leiro, M.G., Segovia-Cubero, J., Sayado, I., Alonso-Pulpón, L., Martínez-Dolz, L., Sánchez-Lázaro, I., Cebrián, M., Paniagua-Martín, M.J., Marzoa-Rivas, R., Barge-Caballero, E., Arizón del Prado, J.M., Lopez-Granados, A., Castillo-Dieguez, J.C., Cobo-Belaustegui, M., Llano-Cardenal, M., Vázquez de Prada, J.A., Jesús Palomo, Villa, A., Fernández-Yáñez, J., Sousa, I., Pablo Díez, Delgado, J., María J. Ruiz, Escribano, P., Miguel A. Gómez, Paradina, M., Eulàlia Roig, Vicenç Brosa, Mirabet, S., Laura López, Josep Padró, Lage, E., Sobrino, J.M., Rangel, D., Manito, N., Roca-Elías, J., González-Costello, J., Salazar-Mendiguchía, J., Rábago, G., Levy, B., Hernández, R., Villa, F.P., Cardona, M., Farrero, M., Castel, M.A., José L. Lambert, de Molina, B.D., Garrido, I., Blasco, T., Sanz-Julvé, M.L., Portolés, A., de la Fuente, L., López-Díaz, J., Recio, A

    CAJA 15 - LEGAJO II - SIGNATURA 2,6

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    Memorial presentado por Francisco Almenar, de Campanar, exponiendo sus experiencias en la segunda cosecha de la seda.Alguer, F. (1788). Memorial presentado por Francisco Almenar, de Campanar, exponiendo sus experiencias en la segunda cosecha de la seda. Real Sociedad Económica de Amigos del País de Valencia. https://riunet.upv.es/handle/10251/18689Importación Masiv

    Evaluation of the preoperative vasoactive-inotropic score as a predictor of postoperative outcomes in patients undergoing heart transplantation

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    Barge-Caballero, E., Segovia-Cubero, J., González-Vilchez, F., Delgado-Jiménez, J., Pérez-Villa, F., Almenar-Bonet, L., Arizón-Del Prado, J.L., Lage-Gallé, E., De La Fuente-Galán, L., Manito-Lorite, N., Sanz-Julve, M., Villa-Arranz, A., Lambert Rodríguez, J.L., Brossa-Loidi, V., Pascual-Figal, D., Muñiz-García, J., Crespo-Leiro, M

    Using genetic programming to evolve action selection rules in traversal-based automated software testing: results obtained with the TESTAR tool

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    [EN] Traversal-based automated software testing involves testing an application via its graphical user interface (GUI) and thereby taking the user's point of view and executing actions in a human-like manner. These actions are decided on the fly, as the software under test (SUT) is being run, as opposed to being set up in the form of a sequence prior to the testing, a sequence that is then used to exercise the SUT. In practice, random choice is commonly used to decide which action to execute at each state (a procedure commonly referred to as monkey testing), but a number of alternative mechanisms have also been proposed in the literature. Here we propose using genetic programming (GP) to evolve such an action selection strategy, defined as a list of IF-THEN rules. Genetic programming has proved to be suited for evolving all sorts of programs, and rules in particular, provided adequate primitives (functions and terminals) are defined. These primitives must aim to extract the most relevant information from the SUT and the dynamics of the testing process. We introduce a number of such primitives suited to the problem at hand and evaluate their usefulness based on various metrics. We carry out experiments and compare the results with those obtained by random selection and also by Q-learning, a reinforcement learning technique. Three applications are used as Software Under Test (SUT) in the experiments. The analysis shows the potential of GP to evolve action selection strategies.Esparcia Alcázar, AI.; Almenar-Pedrós, F.; Vos, TE.; Rueda Molina, U. (2018). Using genetic programming to evolve action selection rules in traversal-based automated software testing: results obtained with the TESTAR tool. Memetic Computing. 10(3):257-265. https://doi.org/10.1007/s12293-018-0263-8S257265103Aho P, Menz N, Rty T (2013) Dynamic reverse engineering of GUI models for testing. In: Proceedings of 2013 international conference on control, decision and information technologies (CoDIT’13)Aho P, Oliveira R, Algroth E, Vos T (2016) Evolution of automated testing of software systems through graphical user interface. In: Procs. of the 1st international conference on advances in computation, communications and services (ACCSE 2016), Valencia, pp 16–21Alegroth E, Feldt R, Ryrholm L (2014) Visual GUI testing in practice: challenges, problems and limitations. Empir Softw Eng 20:694–744. https://doi.org/10.1007/s10664-013-9293-5Barr ET, Harman M, McMinn P, Shahbaz M, Yoo S (2015) The oracle problem in software testing: a survey. IEEE Trans Softw Eng 41(5):507–525Bauersfeld S, Vos TEJ (2012) A reinforcement learning approach to automated GUI robustness testing. In: Fast abstracts of the 4th symposium on search-based software engineering (SSBSE 2012), pp 7–12Bauersfeld S, de Rojas A, Vos T (2014) Evaluating rogue user testing in industry: an experience report. In: 2014 IEEE eighth international conference on research challenges in information science (RCIS), pp 1–10. https://doi.org/10.1109/RCIS.2014.6861051Bauersfeld S, Vos TEJ, Condori-Fernández N, Bagnato A, Brosse E (2014) Evaluating the TESTAR tool in an industrial case study. In: 2014 ACM-IEEE international symposium on empirical software engineering and measurement, ESEM 2014, Torino, Italy, September 18–19, 2014, p 4Bauersfeld S, Wappler S, Wegener J (2011) A metaheuristic approach to test sequence generation for applications with a GUI. In: Cohen MB, Ó Cinnéide M (eds) Search based software engineering: third international symposium, SSBSE 2011, Szeged, Hungary, September 10-12, 2011. Proceedings. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 173–187Brameier MF, Banzhaf W (2010) Linear genetic programming, 1st edn. Springer, New YorkChaudhary N, Sangwan O (2016) Metrics for event driven software. Int J Adv Comput Sci Appl 7(1):85–89Esparcia-Alcázar AI, Almenar F, Martínez M, Rueda U, Vos TE (2016) Q-learning strategies for action selection in the TESTAR automated testing tool. In: Proceedings of META 2016 6th international conference on metaheuristics and nature inspired computing, pp 174–180Esparcia-Alcázar AI, Almenar F, Rueda U, Vos TEJ (2017) Evolving rules for action selection in automated testing via genetic programming–a first approach. In: Squillero G, Sim K (eds) Applications of evolutionary computation: 20th European conference, evoapplications 2017, Amsterdam, The Netherlands, April 19–21, 2017, Proceedings, part II. Springer, pp 82–95. https://doi.org/10.1007/978-3-319-55792-2_6Esparcia-Alcázar AI, Moravec J (2013) Fitness approximation for bot evolution in genetic programming. Soft Comput 17(8):1479–1487. https://doi.org/10.1007/s00500-012-0965-7He W, Zhao R, Zhu Q (2015) Integrating evolutionary testing with reinforcement learning for automated test generation of object-oriented software. Chin J Electron 24(1):38–45Koza JR (1992) Genetic programming: on the programming of computers by means of natural selection. MIT Press, CambridgeLehman J, Stanley KO (2011) Novelty search and the problem with objectives. In: Riolo R, Vladislavleva E, Moore JH (eds) Genetic programming theory and practice IX, genetic and evolutionary computation. Springer, New York, pp 37–56Memon AM, Soffa ML, Pollack ME (2001) Coverage criteria for GUI testing. In: Proceedings of ESEC/FSE 2001, pp 256–267Rueda U, Vos TEJ, Almenar F, Martínez MO, Esparcia-Alcázar AI (2015) TESTAR: from academic prototype towards an industry-ready tool for automated testing at the user interface level. In: Canos JH, Gonzalez Harbour M (eds) Actas de las XX Jornadas de Ingeniería del Software y Bases de Datos (JISBD 2015), pp 236–245Seesing A, Gross HG (2006) A genetic programming approach to automated test generation for object-oriented software. Int Trans Syst Sci Appl 1(2):127–134Vos TE, Kruse PM, Condori-Fernández N, Bauersfeld S, Wegener J (2015) TESTAR: tool support for test automation at the user interface level. Int J Inf Syst Model Des 6(3):46–83. https://doi.org/10.4018/IJISMD.2015070103Wappler S, Wegener J (2006) Evolutionary unit testing of object-oriented software using strongly-typed genetic programming. In: Proceedings of the 8th annual conference on genetic and evolutionary computation, GECCO’06. ACM, New York, NY, USA, pp 1925–1932. URL https://doi.org/10.1145/1143997.1144317Watkins C (1989) Learning from delayed rewards. Ph.D. Thesis. Cambridge Universit

    On the zeroes and the critical points of a solution of a second order half-linear differential equation

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    This paper presents two methods to obtain upper bounds for the distance between a zero and an adjacent critical point of a solution of the second-order half-linear di¿erential equation p x ¿ y q x ¿ y 0, with p x and q x piecewise continuous and p x > 0, ¿ t |t| r¿2 t and r being real such that r > 1. It also compares between them in several examples. Lower bounds i.e., Lyapunov inequalities for such a distance are also provided and compared with other methods.This work has been supported by the Spanish Ministry of Science and Innovation Project DPI2010-C02-01.Almenar, P.; Jódar Sánchez, LA. (2012). On the zeroes and the critical points of a solution of a second order half-linear differential equation. Abstract and Applied Analysis. 2012(ID 78792):1-18. doi:10.1155/2012/787920S1182012ID 78792Almenar, P., & Jódar, L. (2012). An upper bound for the distance between a zero and a critical point of a solution of a second order linear differential equation. Computers & Mathematics with Applications, 63(1), 310-317. doi:10.1016/j.camwa.2011.11.023Li, H. J., & Yeh, C. C. (1995). Sturmian comparison theorem for half-linear second-order differential equations. Proceedings of the Royal Society of Edinburgh: Section A Mathematics, 125(6), 1193-1204. doi:10.1017/s0308210500030468Yang, X. (2003). On inequalities of Lyapunov type. Applied Mathematics and Computation, 134(2-3), 293-300. doi:10.1016/s0096-3003(01)00283-1Lee, C.-F., Yeh, C.-C., Hong, C.-H., & Agarwal, R. P. (2004). Lyapunov and Wirtinger inequalities. Applied Mathematics Letters, 17(7), 847-853. doi:10.1016/j.aml.2004.06.016Pinasco, J. P. (2004). Lower bounds for eigenvalues of the one-dimensionalp-Laplacian. Abstract and Applied Analysis, 2004(2), 147-153. doi:10.1155/s108533750431002xPinasco, J. P. (2006). Comparison of eigenvalues for the p-Laplacian with integral inequalities. Applied Mathematics and Computation, 182(2), 1399-1404. doi:10.1016/j.amc.2006.05.027Almenar, P., & Jódar, L. (2009). Improving explicit bounds for the solutions of second order linear differential equations. Computers & Mathematics with Applications, 57(10), 1708-1721. doi:10.1016/j.camwa.2009.03.076Moore, R. (1955). The behavior of solutions of a linear differential equation of second order. Pacific Journal of Mathematics, 5(1), 125-145. doi:10.2140/pjm.1955.5.12

    The falling incidence of hematologic cancer after heart transplantation

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    This study formed part of the clinical and translational heart failure research program of the cardiovascular disease network of the Instituto de Salud Carlos III(RD12/0042), of which several of the present authors are members.Crespo-Leiro, M.G., Delgado-Jiménez, J., López, L., Alonso-Pulpón, L., González-Vilchez, F., Almenar-Bonet, L., Rábago, G., Pérez-Villa, F., Paniagua Martín, M.J., Arizón del Prado, J.M., Sousa-Casasnovas, I., Manito-Lorite, N., Díaz-Molina, B., Pascual-Figal, D., Lage-Galle, E., Blasco-Peiró, T., De la Fuente-Galán, L., Muñiz, J

    New results on the sign of the Green function of a two-point n-th order linear boundary value problem

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    [EN] This paper provides conditions for determining the sign of all the partial derivatives of the Green functions of n-th order boundary value problems subject to a wide set of homogeneous two-point boundary conditions, removing restrictions of previous results about the distance between the two extremes that define the problem. To do so, it analyzes the sign of the derivatives of the solutions of related two-point n-th order boundary value problems subject to n ¿ 1 boundary conditions by introducing a new property denoted by `hyperdisfocality¿Almenar-Belenguer, P.; Jódar Sánchez, LA. (2022). New results on the sign of the Green function of a two-point n-th order linear boundary value problem. Boundary Value Problems. 1-22. https://doi.org/10.1186/s13661-022-01631-zS122Elias, U.: Oscillation Theory of Two-Term Differential Equations. Kluwer, Dordrecht (1997)Almenar, P., Jódar, L.: The sign of the Green function of an nth order linear boundary value problem. Mathematics 8(5), 673 (2020). https://doi.org/10.3390/math8050673Coppel, W.A.: Disconjugacy. Springer, Berlin (1971)Eloe, P.W., Hankerson, D., Henderson, J.: Positive solutions and conjugate points for multipoint boundary value problems. J. Differ. Equ. 95, 20–32 (1992)Eloe, P.W., Henderson, J.: Focal point characterizations and comparisons for right focal differential operators. J. Math. Anal. Appl. 181, 22–34 (1994)Webb, J.R.L.: Estimates of eigenvalues of linear operators associated with nonlinear boundary value problems. Dyn. Syst. Appl. 23, 415–430 (2014)Almenar, P., Jódar, L.: Estimation of the smallest eigenvalue of an nth order linear boundary value problem. Math. Methods Appl. Sci. 44, 4491–4514 (2021). https://doi.org/10.1002/mma.7047Almenar, P., Jódar, L.: The principal eigenvalue of some nth order linear boundary value problems. Bound. Value Probl. 2021, Article ID 84 (2021). https://doi.org/10.1186/s13661-021-01561-2Almenar, P., Jódar, L.: Accurate estimations of any eigenpairs of n-th order linear boundary value problems. Mathematics 21, 2663 (2021). https://doi.org/10.3390/math9212663Krein, M.G., Rutman, M.A.: Linear Operators Leaving Invariant a Cone in a Banach Space. Am. Math. Soc., New York (1950)Erbe, L.H.: Eigenvalue criteria for existence of positive solutions to nonlinear boundary value problems. Math. Comput. Model. 32(5–6), 529–539 (2000)Webb, J.R.L., Lan, K.Q.: Eigenvalue criteria for existence of multiple positive solutions of nonlinear boundary value problems of local and nonlocal type. Topol. Methods Nonlinear Anal. 27, 91–116 (2006)Lan, K.Q.: Eigenvalues of semi-positone Hammerstein integral equations and applications to boundary value problems. Nonlinear Anal. 71(12), 5979–5993 (2009)Webb, J.R.L.: A class of positive linear operators and applications to nonlinear boundary value problems. Topol. Methods Nonlinear Anal. 39, 221–242 (2012)Ciancaruso, F.: Existence of solutions of semilinear systems with gradient dependence via eigenvalue criteria. J. Math. Anal. Appl. 482(1), 1–22 (2020). https://doi.org/10.1016/j.jmaa.2019.123547Levin, A.J.: Some problems bearing on the oscillation of solutions of linear differential equations. Sov. Math. Dokl. 4, 121–124 (1963)Pokornyi, J.V.: Some estimates of the Green’s function of a multi-point boundary value problem. Mat. Zametki 4, 533–540 (1968)Karlin, S.: Total positivity, interpolation by splines and Green’s functions for ordinary differential equations. J. Approx. Theory 4(1), 91–112 (1971)Peterson, A.: On the sign of Green’s functions. J. Differ. Equ. 21, 167–178 (1976)Peterson, A.: Green’s functions for focal type boundary value problems. Rocky Mt. J. Math. 9(4), 721–732 (1979)Elias, U.: Green’s functions for a non-disconjugate differential operator. J. Differ. Equ. 37, 318–350 (1980)Peterson, A., Ridenhour, J.: Comparison theorems for Green’s functions for focal boundary value problems. In: Agarwal, R.P. (ed.) Recent Trends in Differential Equations. World Scientific Series in Applicable Analysis, vol. 1, pp. 493–506. World Scientific, Singapore (1992)Eloe, P.W., Ridenhour, J.: Sign properties of Green’s functions for a family of two-point boundary value problems. Proc. Am. Math. Soc. 120(2), 443–452 (1994)Webb, J.R.L., Infante, G.: Positive solutions of nonlocal boundary value problems: a unified approach. J. Lond. Math. Soc. 74(2), 673–693 (2006). https://doi.org/10.1112/S0024610706023179Webb, J.R.L., Infante, G.: Nonlocal boundary value problems of arbitrary order. J. Lond. Math. Soc. 79(1), 238–258 (2009). https://doi.org/10.1112/jlms/jdn066Cabada, A., Saavedra, L.: The eigenvalue characterization for the constant sign Green’s functions of (k,nk)(k,n-k) problems. Bound. Value Probl. 44, 1–35 (2016). https://doi.org/10.1186/s13661-016-0547-1Nehari, Z.: Disconjugate linear differential operators. Trans. Am. Math. Soc. 129(3), 500–516 (1967)Hartman, P.: Ordinary Differential Equations. Birkhäuser, Boston (1982
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