2,428 research outputs found
sj-docx-1-aut-10.1177_13623613231205748 – Supplemental material for Validity and feasibility of using the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in primary care clinics in Singapore
No full textSupplemental material, sj-docx-1-aut-10.1177_13623613231205748 for Validity and feasibility of using the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in primary care clinics in Singapore by Ruth Mingli Zheng, Siew Pang Chan, Evelyn C Law, Shang Chee Chong and Ramkumar Aishworiya in Autism</p
sj-docx-2-aut-10.1177_13623613231205748 – Supplemental material for Validity and feasibility of using the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in primary care clinics in Singapore
No full textSupplemental material, sj-docx-2-aut-10.1177_13623613231205748 for Validity and feasibility of using the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in primary care clinics in Singapore by Ruth Mingli Zheng, Siew Pang Chan, Evelyn C Law, Shang Chee Chong and Ramkumar Aishworiya in Autism</p
Alcohol Dehydrogenase Biosensor based on Poly (Aniline)-Poly (Vinylsulfonate) modified electrode and enhancement effect of CA2+ ions on the Electrocatalytic oxidation of NADH at Poly(Aniline)-Poly (Vinylsulfonate) and Poly (Aniline)-Poly (Styrenesulfonate) modified Electrodes
No full textA membrane enzyme electrode sensitive towards ethanol was fabricated based on poly(aniline)-poly(vinylsulfonate) modified electrodes. Using the membrane electrode design and by varying the physical parameters, we established that the membrane enzyme electrode current response was consistent with a reversible enzyme kinetic model. Under conditions in which the product concentration was negligible within the enzyme layer of the enzyme electrode, the substrate-dependent current response could be described using a coupled reaction-diffusion model based on irreversible enzyme kinetics. This is the first report on the use of poly(aniline) modified electrodes as amperoraetric biosensors for the detection of ethanol. In the second part of this work, we investigated the enhancement of steady-state current towards NADH at poly(aniline)-poly(vinylsulfonate) and poly(aniline)- poly(styrenesulfonate) modified electrodes in the presence of calcium ions, using electrochemical methods, ^'P NMR and kinetic modelling. We observed reversible binding between Ca^^ and poly(aniline)-poly(vinylsulfonate) from cyclic voltammetry and steady- state experiments. The enhancement of electrocatalytic current towards NADH in the presence of between 20 and 40 mM Ca^^ were about 12 and 27 times for thin films of poly(aniline)-poly(vinylsulfonate) and poly(aniline)-poly(styrenesulfonate), respectively. This enhancement effect of Ca^^ ions on the electrocatalytic oxidation of NADH at poly(aniline) modified electrodes was much greater than those observed by workers using other mediators. From kinetic modelling of the experimental data, we found that the enhancement effect of Ca^^ ions was due to a large change in the polymer binding affinity for NADH or partitioning of NADH into the polymer film. The binding energy gain was estimated to be about 14 kJ m o f' in the presence of 25 mM Ca^^. This was confirmed by measurements using solid state ^'P NMR which indicated that NADH accumulated in the polymer film only in the presence of Ca^^.</p
On the extension of 𝐻^{𝑝}-functions in polydiscs
No full textFor
N
=
2
or
3
N = 2\;{\text {or}}\;3
it is shown that if
E
E
is the zero set of a holomorphic function in
U
N
{U^N}
satisfying the separation condition of Alexander [1], viz., there exist
r
∈
(
0
,
1
)
r \in (0,1)
and
δ
>
0
\delta > 0
such that
|
α
−
β
|
⩾
δ
\left | {\alpha - \beta } \right | \geqslant \delta
whenever
(
z
′
,
α
,
z
)
≠
(
z
′
,
β
,
z
)
(z’,\alpha ,z) \ne (z’,\beta ,z)
are both in
(
Q
k
−
1
×
U
×
Q
N
−
k
)
∩
E
({Q^{k - 1}} \times U \times {Q^{N - k}}) \cap E
, where
Q
=
{
λ
∈
C
:
r
>
|
λ
|
>
1
}
Q = \{ \lambda \in {\mathbf {C}}:r > \left | \lambda \right | > 1\}
, then (a)
E
E
is the zero set of some
F
∈
H
∞
(
U
N
)
F \in {H^\infty }({U^N})
, and (b)
0
>
p
⩽
∞
0 > p \leqslant \infty
, every
g
∈
H
(
E
)
g \in H(E)
such that
|
g
|
p
{\left | g \right |^p}
has a pluriharmonic majorant on
E
E
extends to a
G
∈
H
p
(
U
N
)
G \in {H^p}({U^N})
. This generalizes earlier results of the author [3] and Zarantonello [9].</p
Effects of tuberculosis and HIV infection on whole-body protein metabolism during feeding, measured by the [15N]glycine method
No full textBackground: Tuberculosis (TB) and HIV infection are wasting diseases that frequently occur together and have severe consequences on nutritional status.Objective: The objective was to determine the effects of TB and HIV, separately and together, on protein metabolism.Design: Protein metabolism was determined in the fed state in 11 healthy control subjects, in 10 patients with HIV infection without TB or other active infection (HIV group), in 10 patients with active TB without HIV infection (TB group), and in 8 patients with HIV infection and active TB (HIVTB group) with the use of oral [15N]glycine and measurement of enrichment in urinary urea and ammonia.Results: Whole-body protein flux and degradation were lower in the HIV group than in the control group (mean flux: 3.53 ± 0.40 compared with 4.75 ± 0.97 g · kg lean body mass-1 · 12 h-1; P = 0.002). Protein flux, synthesis, and degradation were not significantly different between the control group and the TB and HIVTB groups. Net protein balance was strongly anabolic in the control, HIV, and TB groups but was neutral in the HIVTB group (P < 0.001 for comparison between groups).Conclusions: HIV infection was associated with a significant down-regulation of whole-body protein flux. TB alone was not associated with abnormal protein metabolism, but net anabolism in the fed state was impaired in the HIVTB group
Combinatorial complexity of signed discs
No full textLet and be two collections of topological discs of
arbitrary radii. The collection of discs is `topological' in the
sense that their boundaries are Jordan curves and each pair of Jordan
curves intersect at most twice. We prove that the region has combinatorial complexity at most where
, and . Moreover, this bound is
achievable. We also show bounds that are stated as functions of
and . These are less precise.Technical report LCSR-TR-19
Exploring if day and time of admission is associated with average length of stay among inpatients from a tertiary hospital in Singapore: an analytic study based on routine admission data.
No full textBACKGROUND: It has been postulated that patients admitted on weekends or after office hours may experience delays in clinical management and consequently have longer length of stay (LOS). We investigated if day and time of admission is associated with LOS in Tan Tock Seng Hospital (TTSH), a 1,400 bed acute care tertiary hospital serving the central and northern regions of Singapore. METHODS: This was a historical cohort study based on all admissions from TTSH from 1st September 2003 to 31st August 2004. Data was extracted from routinely available computerized hospital information systems for analysis by episode of care. LOS for each episode of care was log-transformed before analysis, and a multivariate linear regression model was used to study if sex, age group, type of admission, admission source, day of week admitted, admission on a public holiday or eve of public holiday, admission on a weekend and admission time were associated with an increased LOS. RESULTS: In the multivariate analysis, sex, age group, type of admission, source of admission, admission on the eve of public holiday and weekends and time of day admitted were independently and significantly associated with LOS. Patients admitted on Friday, Saturday or Sunday stayed on average 0.3 days longer than those admitted on weekdays, after adjusting for potential confounders; those admitted on the eve of public holidays, and those admitted in the afternoons and after office hours also had a longer LOS (differences of 0.71, 1.14 and 0.65 days respectively). CONCLUSION: Cases admitted over a weekend, eve of holiday, in the afternoons, and after office hours, do have an increased LOS. Further research is needed to identify processes contributing to the above phenomenon
A brief structured education programme enhances self-care practices and improves glycaemic control in Malaysians with poorly controlled diabetes
No full textWe assessed the effectiveness of a brief structured diabetes education programme based on the concept of self-efficacy on self-care and glycaemic control using single-blind study design. One hundred and sixty-four participants with poorly controlled diabetes from two settings were randomized using computer-generated list into control (n = 82) and intervention (n = 82) groups, of which 151 completed the study. Monthly interventions over 12 weeks addressed the self-care practices of diet, physical activity, medication adherence and self-monitoring of blood glucose (SMBG). These self-care practices were assessed at Weeks 0 and 12 using pre- and post-questionnaires in both groups together with glycated haemoglobin A1c (HbA1c) and diabetes knowledge. In the intention-to-treat analysis (n = 164), the intervention group improved their SMBG (P = <0.001), physical activity (P = 0.001), HbA1c (P = 0.03), diabetes knowledge (P = <0.001) and medication adherence. At Week 12, HbA1c difference adjusted for SMBG frequency, medication adherence and weight change remained significant (P = 0.03) compared with control group. For within group comparisons, diabetes knowledge (P = <0.001), HbA1c level (P = <0.001), SMBG (P = <0.001) and medication adherence (P = 0.008) improved from baseline in the intervention group. In the control group, only diabetes knowledge improved (P = <0.001). These findings can contribute to the development of self-management diabetes education in Malaysia.M. Y. Tan, J. M. Magarey, S. S. Chee, L. F. Lee and M. H. Ta
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