2,609 research outputs found
Editorial IPRD06
No full textEditorial dei Proceedings del 10th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD06) 1 - 5 October 2006 Siena, Ital
Editorial
No full textEditoriale dei Proceedings del 9th Topical Seminar on Innovative Particle and Radiation Detectors 23 - 26 May 2004 Siena, Ital
Overall and disease-free survival greater than 12 years in metastatic non-small cell lung cancer after linear accelerator-based stereotactic radiosurgery for solitary brain metastasis
No full textThe best treatment approach for solitary brain metastasis is not well defined and there is no consensus on this issue. It is still being debated whether patients with isolated brain metastasis should undergo surgical resection or stereotactic radiosurgery, and which patients should receive adjuvant whole brain radiotherapy. The median survival in patients with single or multiple metastatic lesions who underwent only stereotactic radiosurgery improved from two-three months to nine months. To the best of our knowledge this is the first report on patients treated with linear accelerator-based stereotactic radiosurgery alone where an overall survival of more than 12 years was obtained, maintaining good quality of life in three cases of solitary brain metastasis from non-small cell lung cancer. In addition to the case reports, we present a brief literature review on this topic. © Il Pensiero Scientifico Editore
Current status and recent advances in reirradiation of glioblastoma
No full textDespite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO grade IV gliomas (glioblastomas, GBM) will recur locally within 2 years. For patients with recurrent GBM, no standard of care exists. Thanks to the continuous improvement in radiation science and technology, reirradiation has emerged as feasible approach for patients with brain tumors. Using stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT), either hypofractionated or conventionally fractionated schedules, several studies have suggested survival benefits following reirradiation of patients with recurrent GBM; however, there are still questions to be answered about the efficacy and toxicity associated with a second course of radiation. We provide a clinical overview on current status and recent advances in reirradiation of GBM, addressing relevant clinical questions such as the appropriate patient selection and radiation technique, optimal dose fractionation, reirradiation tolerance of the brain and the risk of radiation necrosis
Stereotactic radiosurgery for patients with brain metastases
No full textWe read with interest the Article by Masaaki Yamamoto and colleagues1 about the use of stereotactic radiosurgery in patients with one to ten brain metastases. Their prospective, observational study was well designed and they enrolled many patients (n=1194); nevertheless, their findings raise several relevant questions about stereotactic radiosurgery and whole-brain radiotherapy. We have several concerns about the study. First, overall survival is not an appropriate primary endpoint to assess the effectiveness of a local therapy such as brain stereotactic radiosurgery
Innovative Particle and Radiation Detectors. Proceedings of the 10th Topical Seminar on Innovative Particle and Radiation Detectors
No full textOptimized software for a compact gamma camera
No full textIn a preceding work a new compact gamma camera based on the Hamamatsu H8500 PSPMT and on a custom developed electronics was presented [1]. The core element of such electronics is a microcontroller that operates the transfer of the sampled data to a PC using a USB link in full speed modality; This transfer utilizes on one side a firmware that controls the operation performed by the microcontroller and on the other side a software that trough a graphical interface make the analysis of the acquired data possible. Both were optimized considering the nature of the data coming from the gamma camera and on the other the limitation imposed by the USB protocol. Although they were conceived for a particular gamma camera the requirements and optimizations realized still have a general interest for any position sensitive based gamma camera. ©2009 IEEE
10th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD06) 1 - 5 October 2006 Siena, Italy
No full textThe Tenth Topical Seminar on "Innovative particle and radiation detectors" IPRD06 will take place in the Auditorium of the Graduate College Santa Chiara of the University of Siena, Italy, from 1 to 5 October 2006.
The conference proceedings will be published in Nuclear Physics B (Proceedings Supplement).
The Seminar is the tenth in a series devoted since more than 20 years to experimental apparatus for high-energy particle physics and astrophysics. The previous ones were held in San Miniato (1984, 1986, 1988, 1990, 1993, 1996, 1998) and in Siena (2002, 2004). The 2006 Seminar will again focus on advanced technologies in particle physics at collider experiments, and in cosmic ray and astrophysics experiments, including balloon-borne and space based experiments. Special attention will be devoted to the application of these detectors in other fields, such as detectors for medicine and biology, security control, and environmental monitoring. The participation of representatives from industry will make it possible to discuss future applications of basic research. The Seminar will be based on review talks summarizing the progress of complex R&D projects and major facilities. Shorter talks will cover contributions on specific items. The presentation of posters is also foreseen
Ce doped lanthanum tri-bromide SPET scanner for molecular imaging RID F-8402-2011
No full textThe availability of LaBr(3):Ce crystals from St. Gobain has started various investigations in the field of medical imaging, in particular in PET, SPECT and Compton camera systems. At present LaBr(3):Ce crystals are available in a continuous shape covering up to 10 x 10 cm(2) with a thickness of 1 cm, in contrast, serious concerns are arising in pixellated manufacturing. With the aim of verifying the potentials introduced by LaBr(3):Ce for SPET imaging, two small gamma cameras based on Anger camera principle have been assembled and imaging performances were compared. Two crystals of LaBr(3):Ce and NaI(Tl) with the same detection area (5 x 5 cm(2)) and thickness of 5 and 1.5 mm, respectively were been integrally assembled with a H8500 Hamamatsu flat panel PMT. Through the thicker crystal, the LaBr(3):Ce camera showed superior imaging and detection performances at 140 keV compared with the NaI(Tl) one, with 0.9 mm FWHM intrinsic spatial resolution, 8% FWHM energy resolution and 80% intrinsic detection efficiency. (c) 2006 Elsevier B.V. All rights reserved
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