10,911 research outputs found
Thirty-two-year-old Michigan State University undergraduate Bill Bock reminisces about growing up in Alpena, Michigan, his career interest, relationship with classmates, and family life on campus
No full textThirty-two-year-old Michigan State University undergraduate Bill Bock reminisces about growing up in Alpena, Michigan and says that even though he read voraciously as a youth, he was an unmotivated and mediocre student. He credits one of his high school teachers with encouraging him to major in elementary education, but says that he doesn't really want to be a teacher for the rest of his life, but does want to be involved in education. Bock expresses frustration with his younger, ill-informed classmates and admits lacking a connection with them. He also talks about the adjustment his wife and kids had to make to living on campus and wishes the pace at MSU were a little slower
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Kaye Bock Award Winners
No full textThe Kaye Bock Award is given to the author (or authors) of the best paper, as determined by the editors, in each issue of the Berkeley Planning Journal that was written by a student (or a team of students). The award is named in loving memory of Kaye Bock to honor her unbounded concern for and commitment to graduate students. This award is also intended to be an eternal expression of gratitude from the Berkeley Planning Journal to Kaye for her critical and caring support during our first two decades of publication. The Kaye Bock Award is accompanied by a $250 cash gift
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Kaye Bock Student Paper Award
No full textThe Kaye Bock Student Paper Award is given to the author of the paper that is both an outstanding example of scholarship and exemplifies Kaye's commitment to underrepresented issues or peoples. The award is named in loving memory of Kaye Bock to honor her unbounded concern for and commitment to graduate students in the Department of City and Regional Planning. It is also intended as an expression of gratitude from the Berkeley Planning Journal to Kaye for her critical and caring support of the journal during our first two decades of publication. The winner is chosen by the editors of each volume of the Berkeley Planning Journal. The Kaye Bock Student Paper Award is accompanied by a $250 cash gift
Father Edward Bock
No full textPhotograph used for a story in the Oklahoma Times newspaper. Caption: "FATHER EDWARD BOCK Ada. The best answer to that, is just be good parents all the way around, and the school can take it from there.
Long-lived metastable state and hysteresis in the binding of acetylcholine to Torpedo californica acetylcholine receptor
No full textChang HW, Bock E, Neumann E. Long-lived metastable state and hysteresis in the binding of acetylcholine to Torpedo californica acetylcholine receptor. Biochemistry. 1984;23(20):4546-4556
Dynamic ligand binding of dualsteric (allosteric/orthosteric) molecular probes controls the graded activation of muscarinic acetylcholine receptors
No full textWe investigated a class of bitopic (dualsteric) ligands of the M2 acetylcholine muscarinic receptor (M2AChR), i.e. compounds whose pharmacophoric groups are able to target the orthosteric as well as the allosteric binding site of the receptor.1,2 These model derivatives are composed of an allosteric fragment, an intermediate linker and an orthosteric moiety. As an example, ligands 1 and 2 incorporate the molecular portion of the allosteric compound Naphmethonium and the potent muscarinic agonist Iperoxo, which are connected by a flexible or a rigidified spacer group, respectively (Figure 1). These bipharmacophoric molecular probes were found to switch between two different binding orientations, resulting in both active and inactive populations of receptors bound by a given ligand, a behavior that has been termed dynamic ligand binding.3
Figure 1
In this study, pharmacological data analysis and computational simulations based on active and inactive M2AChR crystal structures led to identify two distinct binding topographies in a group of dualsteric partial agonists. One binding mode, which resembled that of the co-crystallized orthosteric ligand Iperoxo, engendered an agonist response. Conversely, dualsteric ligands binding to the allosteric site only showed a receptor-complex comparable to that of allosteric modulators. Thus, the observed agonist efficacies depended on the fraction of dualsteric (i.e. active) vs. purely allosteric (i.e. inactive) binding modes.4
References
1. Antony, J.; Kellershon, K.; Mohr-Andrä, M.; Kebig, A.; Prilla, S.; Muth, M.; Heller, E.; Disingrini, T.; Dallanoce, C.; Bertoni, S.; Schrobang, J.; Tränkle, C.; Kostenis, E.; Christopoulos, A.; Höltje, H.-D.; Barocelli, E.; De Amici, M.; Holzgrabe, U.; Mohr, K. FASEB J. 2009, 23, 442-450.
2. Bock, A.; Merten, N.; Schrage, R.; Dallanoce, C.; Bätz, J.; Klöckner, J.; Schmitz, J.; Matera, C.; Simon, K.; Kebig, A.; Peters, L.; Müller, A.; Schrobang-Ley, J.; Tränkle, C.; Hoffmann, C.; De Amici, M.; Holzgrabe, U.; Kostenis, E.; Mohr; K. Nat. Commun. 2012, 3:1044, doi: 10.1038/ncomms2028.
3. Bock, A.; Chirinda, B.; Krebs, F.; Messerer, R.; Bätz, J.; Muth, M.; Dallanoce, C.; Klingenthal, D.; Tränkle, C.; Hoffmann, C.; De Amici, M.; Holzgrabe, U.; Kostenis, E.; Mohr, K. Nat. Chem. Biol. 2014, 10, 18-20.
4. Bock, A.; Bermudez, M.; Krebs, F.; Matera, C.; Chirinda, B.; Sydow, D.; Dallanoce, C.; Holzgrabe, H.; De Amici, M.; Lohse, M.; Wolber, G.; Mohr, K. J. Biol. Chem., in press
Drosophila (Sophophora) rhopaloa Bock & Wheeler 1972
No full textDrosophila (Sophophora) rhopaloa Bock & Wheeler, 1972 (Figure 1C, D, F, H, J, L, N, Figure 2B, D, F, H, Figure 3B, D, F) Drosophila rhopaloa Bock & Wheeler, 1972:69; Singh & Gupta, 1977: 35; Okada & Carson, 1983: 137 Drosophila (Sophophora) coonorensis Reddy & Krishnamurthy, 1973: 262 This species has been extensively described by others, and the present work illustrates many aspects of its morphology in comparison to D. carrolli n. sp. Therefore, we have chosen to not include a redescription here. Material examined. D. rhopaloa line BaVi 067 and BaVi 5327 from Vietnam, Hanoi Ba Vì, near Vân Hòa [21°04′N, 105°22′E], March 2005, H. Takamori leg. Previous records. Malaysia: Borneo, Sabah, Mt. Kinabalu (Takada, Momma, & Shima, 1973). India: Meghalaya, Shillong (Singh & Gupta, 1977); Madras, Nilgiri, Coonoor (type of D. coonorensis Reddy & Krishnamurthy, 1973). Thailand: Khao Yai [14°26’21.03”N 101°22’20.95”E], type locality. Papua New Guinea: Morobe Province, Mt Kaindi, Kunai Creek (1500 m.), 3.XI.1977 (H. Carson leg.) (Okada & Carson, 1983). Okada & Carson describe these specimens from Papua New Guinea as “exceedingly” different from those of Java, being in particular darker. The identity of these specimens is therefore questionable, and they may be assigned to D. carrolli n. sp., or to another new taxon. Republic of Indonesia: Java, (Okada & Carson, 1983). Vietnam: Vietnam, Hanoi Ba Vì, near Vân Hòa [21°04′N, 105°22′E], IX.2004 (line BaVi5327) and III.2005 (line BaVi067) (H. Takamori leg.) (Chen et al., 2014; Setoguchi et al., 2014). Brake & Bächli (2008) also report D. rhopaloa from and Sri Lanka, without additional details.Published as part of Gompel, Nicolas & Kopp, Artyom, 2018, Drosophila (Sophophora) carrolli n. sp., a new species from Brunei, closely related to Drosophila (Sophophora) rhopaloa Bock & Wheeler, 1972 (Diptera: Drosophilidae), pp. 502-510 in Zootaxa 4434 (3) on pages 508-509, DOI: 10.11646/zootaxa.4434.3.6, http://zenodo.org/record/129213
Balancing work and family: how does family responsibilities discrimination affect career advancement?
No full textThis exploratory mixed-methods study uses grounded theory to examine the relationship between family responsibilities discrimination (FRD) and career advancement in the public sector. By employing a primarily qualitative embedded research design, semi-structured interviews and exit surveys were conducted in three New Jersey public schools to study a sample of teachers and similarly situated professional staff to investigate the organizational and individual dimensions of FRD, the discretion used by people with family responsibilities, and perceptions of the emerging legal concept of FRD. This study is the first of its kind to examine FRD, as opposed to gender discrimination, in relation to career advancement of public sector employees, specifically public school professionals. The results of the analysis of the data, consisting of qualitative themes extracted from the interviews and descriptive statistics from the exit surveys, show that FRD causes teachers to use discretion at home and work, that current organizational factors not only fail to mitigate effects of FRD on the work/family balancing act but sometimes contribute to them, that there is a lack of awareness of the legal concept of FRD, and that FRD directly and indirectly impedes career advancement in the school system. Based on these preliminary results, recommendations for future research and action in the field are suggested.Ph. D.Includes bibliographical referencesIncludes vitaby Lauren Bock Mullin
« Les tendances actuelles de la recherche médiéviste en France » Deutsch-französisches Kolloquium und Sommerschule (06.-09.06.2017)
No full text Sommerschule (6.-7. Juni 2017) Domplatz 20-22, F 234 Die Sommerschule dient der inhaltlichen und sprachlichen Vorbereitung auf die Vorträge und Diskussionen des Kolloquiums. Sie kann von Münsteraner Studenten als Lehrveranstaltung belegt werden. Die Teilnahme ist nicht Voraussetzung für die Teilnahme am Kolloquium. Kolloquium (8.-9. Juni 2017) Domplatz 20-22, F 234 8. Juni 2017 14h30 : Introduction (Martin Kintzinger, Georg Jostkleigrewe, Nils Bock) 15h00 : Panel I: „Mentalités – Menta..
Brian Bock
No full textA photograph of Brian Bock, number 79, of the 1965 Springfield College Football Team. Brian is on one knee with his helmet cradled in his right arm.The 1965 Springfield College Football team went 9-0-0 and remains the only College Football team to go undefeated and untied during a season. Springfield College’s opponents in ’65-'66 were the US. Coast Guard (30-14), Amherst College (13-0), Williams College (28-8), Colby College (42-13), Northeastern University (16-14), American International College (43-6), Rhode Island University (7-6), University of New Hampshire (43-13), and Wagner College (30-13). The game against Amherst College was televised on Channel 22 and was the first Western Mass football game ever televised in the region. The team received many honors, including Ted Dunn being named UPI New England College Division Coach of the Year and several players received honors including being selected for the All Decade Team. The team came in second to the University of Maine for selection for a bid to play in the Tangerine Bowl in Orlando, FL, December 11, 1965
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