4 research outputs found
Myofunctional therapy: a bibliometric study of the most cited 50 articles
No full textThe objective of this bibliometric analysis was to provide an overview of the current literature status of myofunctional therapy and to assist practitioners and researchers to make clinically relevant decisions and to foster collaborations by mapping out bibliographic information
3-Dimensional Evaluation of Enamel Thickness to Guide Orthodontic Interproximal Reduction: A CBCT-Based Study Across Gender and Ethnicity
Full text linkObjective: This study aimed to explore variations in enamel thickness to provide guidelines for optimal interproximal enamel reduction in an untreated population using cone-beam computed tomography (CBCT).
Methods: CBCT scans of 100 orthodontic patients (51 Caucasian, 49 patients of Somalian descent; aged (12-18) were analyzed retrospectively. Enamel thickness was measured at the mesial and distal contact points of teeth from the second molar to the central incisor in both the maxillary and mandibular arches. Linear mixed models were employed to assess the effects of ethnicity, gender, anterior-posterior region, and mesial-distal proximal surfaces on enamel thickness. Fixed effects were estimated using the Kenward-Roger method, and a random intercept with an unstructured covariance matrix was included to account for within-subject variability. Ethnicity-specific residual variances were also modeled. Statistical significance was set at p<0.05.
Results: Enamel thickness varied significantly between Caucasians and Somalians in both the maxilla and mandible (p0.05).
Conclusion: Posterior teeth, particularly distal proximal surfaces of premolars and molars hold a great potential for enamel reduction, offering clinicians the most optimal site in orthodontic interventions
Remineralization of post-orthodontic white spot lesions with a fluoride varnish and a self-assembling P 11 - 4 peptides: a prospective in-vivo-study
No full textOBJECTIVE
The objective was to evaluate the remineralization effects of fluoride varnish (Clinpro White varnish), self-assembling peptide (Curodont™ Repair) and their combined use on WSL after orthodontic treatment.
MATERIALS AND METHODS
Thirty-two subjects, aged of 10-18 (mean age 13.91 ± 2.92) with 107 post-orthodontic WSL were included in the study. Subjects were divided into four groups as control, tricalcium phosphate (TCP) containing fluoride varnish (Clinpro White varnish) group, self-assembling P11-4 peptides (Curodont™ Repair) group and combined application of the two products. At the beginning, each subjects' caries risk profile was assessed by evaluating diet cariogenicity, plaque index, gingival bleeding index and stimulated salivary flow rate. Before the application of the remineralization agents, WSL baseline demineralization values were determined with QLF Inspektor™ Pro, laser fluorescence using DIAGNOdent and color values were measured by Vita EasyShade. Remineralization data were obtained by measuring ΔF, ΔQ, and lesion area with QLF. The aesthetic improvement after the remineralization process was evaluated with a spectrophotometer at six weeks, three and six months.
RESULTS
No statistically significant differences were found between the groups in terms of criteria determining patients' caries risk profiles, DIAGNOdent data, and plaque index scores (p > 0.05). Intra-group evaluation following remineralization revealed statistically significant increases in ΔF and ΔQ with a decrease in lesion area for the fluoride varnish group at six months, for the peptide group at three months, and for the combined application group at three and six months (p < 0.05). In inter-group comparisons, ΔF and ΔQ values were found to be statistically significant only in the fluoride group at six months compared to the other groups (p < 0.05). While the L* value decreased significantly in all groups at six months, a statistically significant difference in ΔE* values was observed only in the control group between three and six months.
CONCLUSION
Fluoride varnish with TCP showed highest remineralization at 6 months, and the remineralization was positively affected in the short term (three months) after the use of self-assembling P11-4 peptides and their combined application.
CLINICAL RELEVANCE
Remineralization obtained after single application of agents tested in six months in-vivo showed parallel results. In an attempt to trigger subsurface remineralization, the combined use of fluoride with self-assembling peptides as biomimetic remineralization agent needs further evaluation
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 In Vitro
Full text linkRibavirin is a guanosine analog and has a broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 activity of this drug molecule via in vitro, in silico and molecular techniques. Ribavirin showed antiviral activity in Vero E6 cells following SARS-CoV-2 infection whereas the drug itself did not show any toxic effect over the concentration range tested. In silico analysis suggested that Ribarivin has a broad-spectrum impact on SARS-CoV-2, acting at different viral proteins. According to the detailed molecular techniques, Ribavirin was shown to decrease the expression of TMPRSS2 both at mRNA and protein levels 48 hours after treatment. The suppressive effect of Ribavirin in ACE2 protein expression was shown to be dependent on cell types. Finally, proteolytic activity assays showed that Ribavirin also showed an inhibitory effect on TMPRSS2 enzyme. Based on these results, we hypothesized that Ribavirin may inhibit the expression of TMPRSS2 by modulating the formation of inhibitory G-quadruplex structures at the TMPRSS2 promoter. As a conclusion, Ribavirin is a potential antiviral drug for the treatment against SARS-CoV-2, and it interferes with the effect of TMPRSS2 and ACE2 expression.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
