45 research outputs found
Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction
No full textControl of cell proliferation is of fundamental importance to cancer chemotherapy. One of the key signalling events leading to cellular activities (i.e. cell division, proliferation, migration) involves Growth Factors such as Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and Fibroblast Growth Factors (FGFs). They bind to specific transmembrane tyrosine kinase receptors at the cell surface. This can only take place in the presence of heparin and heparan sulfate proteoglycans. The literature in this area is reviewed.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation
No full textThe synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF)
Innentitelbild: Selective RNA Versus DNA G‐Quadruplex Targeting by In Situ Click Chemistry (Angew. Chem. 44/2012)
No full textControl of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group
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ChemInform Abstract: Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group.
No full textA non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
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