34 research outputs found
Assessment of Economic Growth of the Republic of Moldova in the Context of Global Economic Crisis
No full textThe world economic crisis has had a negative impact on the economic development of Moldova, but recent trends show that in 2010 we were able to forecast a small economic growth. The author examines the problems faced by the Moldavian economy which shackle its strong recovery. The current evolutions of the Moldavian economy are analyzed in the paper as well.remittances, foreign trade, competitiveness, structural reforms, macroeconomic environment
LABİOPLASTİ KONULU MAKALELERİN BİLİM HARİTALAMA TEKNİĞİ İLE ANALİZİ
No full textObjective: Labiaplasty is the surgical reduction of the labia minora. Labiaplasty has become increasingly popular in recent years. The aim of this study is to analyze the studies on labiaplasty in the literature with the science mapping technique.
Materials and Methods: The data used in this study were obtained from the Web of Science Core Collection, Scopus and PubMed databases, which contain abstracts and references from high quality and effective scientific articles. The dataset is assembled using the Python programming language and the underlying Pandas library. The obtained data were analyzed with Biblioshiny in R-Studio.
Results: The results of the analysis made on the basis of the countries of the responsible authors of the studies on labiaplasty show that the USA is ahead with a total of 85 articles according to the number of articles. Gemma Sharp is the author with the highest number of articles with 19 articles in terms of total number of articles. The source that publishes the most articles on labiaplasty is the Aesthetic Surgery Journal with 58 articles.
Conclusion: In our article, the subject of labiaplasty has been analyzed in terms of science mapping, which is the most interesting subject of the last period. It is considered that this study, which is frequently encountered in the literature, will shed light on the studies in its field
Determination of mass attenuation coefficients and effective atomic numbers for compounds of the 3d transition elements
No full textIn this study, we aimed to determine mass attenuation coefficient (mu(m)) and effective atomic number (Z(eff)) for some compounds of the 3d transition elements such as CoO, CoF2, CoF3, Cr2O3, CrF2, CrF3, FeO, Fe2O3, MnO2, TiO2, V2O3, VF3, V2O5, VF4 and ZnO at 19.63 and 22.10 keV photon energies by using an HPGe detector with a resolution of 182 eV at 5.9 keV. The experimental results of mu(m) are compared with the theoretical results. Also, effective atomic numbers of compounds of the 3d transition elements have been determined by using experimental and theoretical mass attenuation coefficients. The agreement of measured values of effective atomic numbers with theoretical calculations is quite satisfactory. (C) 2016 Elsevier Ltd. All rights reserved
Characterization of the effective atomic number for first row transition elements by the ratio of coherent to compton scattering intensities obtained by wavelength dispersive X-ray fluorescence
No full textThe effective atomic numbers of compounds of the first row transition elements were determined experimentally by a scattering method using wavelength dispersive X-ray fluorescence spectrometer. A calibration curve was created by using the intensity ratios of coherent to Compton scattered peaks of pure elements from atomic number 13-48. This relationship was employed to determine the effective atomic numbers of the compounds. The effective atomic numbers were also calculated by using empirical formulas from the literature. Mass attenuation coefficients were calculated using software. The experimentally measured values of the effective atomic numbers with the calculated values by empirical formulas were comparable
Do Self-Efficacy and Moral Intelligence have a Role in the Formation of Sportsmanship Behavior?
No full textThe present study is aimed to investigate the effect of empathy, conscience, self-control, kindness and self-efficacy on sportsmanship behaviors, since there is no study that investigated the effects of self-efficacy and moral intelligence on sportsmanship behaviors. For this purpose, the study was carried out according to the relational screening design, which is one of the quantitative research designs. 397 students studying at the faculty of sports sciences participated in the research. "Yakut-Moral Intelligence Scale", "Athlete Self Efficacy Scale" and "Investigation of Sportsmanship Behaviors Scale" were used to carry out the study. Statistical analyzes were made in SPSS 25 program and Pearson correlation and multiple linear regression analysis were used. As a result of the analysis, sportsmanship has been determined that it has a significant relationship with empathy, conscience, self-control, kindness and self-efficacy. As another result of the study, while self-efficacy alone explains 13.4% of sportsmanship, self-efficacy, empathy, self-control and kindness together explain 48% of sportsmanship. It was determined that the sub-dimension of conscience did not have a significant effect on sportsmanship. According to these results, in displaying sportsmanship behaviors; Having a high level of self-efficacy, ability to empathize, power to control behaviors and kindness have an important and powerful effect
Evaluation of Antiepileptic Drugs' Effect on Thyroid Functions and Hematological Parameters in Epileptic Patients
No full textAim of study: Epilepsy is a chronic neurological disorder. Long-term antiepileptic drug use is associated with several metabolic and hormonal disorders. This study aims to investigate the potential effects of antiepileptic drugs on thyroid functions and complete blood counts. Methods: Epileptic adult patients followed up regularly were enrolled in the study. Laboratory parameters including serum thyroid hormone levels and complete blood counts were evaluated retrospectively. The effects of antiepileptic drugs on these parameters of the cases were investigated by comparing the laboratory recordings of the cases in the defined three periods [prior to antiepileptic drug treatment, in between 6 months to 1 year treatment (early stage) and after 1 year treatment (late stage)]. Results: A three hundred epileptic patients (F/M: 175/125) were included in the study. A statistically significant difference in TSH levels and sT4 levels in late stage compared to pre-treatment (p=0.006, p=0.0005, respectively). A statistically significant decrease was recorded in late stage mean leukocyte levels in comparison with pre-treatment levels (p=0.025). When pre-treatment and late stage mean thrombocyte levels were compared, a statistically significant decrease was observed in late phase (p=0.001). Conclusions: According to our study results, widely used antiepileptic drugs in the world have some effects on both thyroid functions and complete blood counts. It is important to emphasize epilepsy treating centers should monitor not only clinical features of the patients but also laboratory results periodically. Key words: epilepsy, antiepileptic drugs, thyroid functions, complete blood counts
Thyroid functions as a parameter in monitoring of antiepileptic drugs
No full textEpilepsy is a chronic neurological disorder that is treated with multiple medications that can have significant side effects. This study investigated the potential effects of antiepileptic drugs on thyroid function.The participants in this study were epileptic adults who had been consistently monitored in follow-up care. The effects of antiepileptic drugs on the serum levels of the thyroid stimulating hormone (TSH), free T3 (fT3), and free T4 (fT4) of these patients were investigated retrospectively by comparing laboratory recordings in three defined periods: prior to antiepileptic drug treatment, between 6 months and 1 year of treatment (early stage), and after 1 year of treatment (late stage). A total of 300 epileptic patients (F/M: 175/125) were included in the study. Significant differences in TSH and fT4 serum levels in the late stage compared to the pre-treatment stage (p = 0.006 and p = 0.0005, respectively) were found. TSH values in the late stage of treatment were abnormally high in one case and low in five cases; all six of these cases had normal pre-treatment and early-stage TSH values. Patients who received monotherapy with valproic acid, levetiracetam or carbamazepine were evaluated separately and there was no statistically significant difference in TSH and fT3 levels, while fT4 levels were significantly increased during treatment in each treatment group.A significant increase in TSH levels was found in epileptic patients on polytherapy. Our results give us the opportunity to highlight the potential unique or cumulative effect of antiepileptic drugs on thyroid hormone levels
Prognostic factors and oncological outcomes of ovarian yolk sac tumors: a retrospective multicentric analysis of 99 cases
No full textPurposeTo investigate the clinico-pathological prognostic factors and treatment outcomes in patients with ovarian yolk sac tumors (YST).MethodsA multicenter, retrospective department database review was performed to identify patients with ovarian YST who underwent surgery between 2000 and 2017 at seven Gynecologic Oncology Centers in Turkey.ResultsThe study group consisted of 99 consecutive patients with a mean age of 23.9years. While 52 patients had early stage (stage I-II) disease, the remaining 47 patients had advanced stage (stage III-IV) disease. Theuterus was preserved in 74 (74.8%) of the cases. The absence of gross residual disease following surgery was achieved in 76.8% of the cases. Of the 54 patients with lymph node dissection (LND), lymph node metastasis was detected in 10 (18.5%) patients. Of the 99 patients, only 3 patients did not receive adjuvant therapy, and most of the patients (91.9%) received BEP (bleomycin, etoposide, cisplatin) chemotherapy. Disease recurred in 21 (21.2%) patients. The 5-year disease-free survival (DFS) and overall survival (OS) in the entire cohort were 79.2% and 81.3%, respectively. In multivariate analysis, only residual disease following initial surgery was found to be significantly associated with DFS and OS in patients with ovarian YST (p=0.026 and p=0.001, respectively).ConclusionsOur results demonstrate the significance of achieving no visible residual disease in patients with ovarian YST. Fertility-sparing approach for patients with no visible residual disease affected neither DFS nor OS. Although high lymphatic involvement rate was detected, the benefit of LND could not be demonstrated
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
No full textNitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse cancer cell models, anti-apoptotic and anti-metastatic features on hepatoma cells. The anti-proliferative studies show that IC(50)values ofN-phenyl-2,4,6-trinitroaniline,N-(2,4,6-trinitrophenyl)naphthalen-1-amine,N-(2,4,6-trinitrophenyl)naphthalen-2-amine,N-(3-nitrophenyl)-2,4,6-trinitroaniline were similar to IC(50)value of cisplatin in Hep3B cells. In fact, IC(50)value ofN-(3,5-difluorophenyl)-2,4,6-trinitroaniline is better than cisplatin. In addition, all compounds could decrease the expression of the cell cycle checkpoint protein cyclin D1. To investigate the effect of compounds on the apoptotic pathway, mRNA and protein expressions of Bcl-2 and Bax were analyzed with qRT-PCR and Western blot. Annexin V staining assay, apoptotic mRNA and protein analysis indicate thatN-isopropyl-2,4,6-trinitroaniline,N-(2,4,6-trinitrophenyl)-5-methylisoxazole-3-amine,N-(3-nitrophenyl)-2,4,6-trinitroaniline,N-(4-nitrophenyl)-2,4,6-trinitroaniline induce intrinsic apoptosis by increasing the ratio of Bax/Bcl-2 expression. In addition, colony formation and wound healing assays confirmed that these compounds also inhibit the metastatic activity of Hep3B cells. 2,4,6-Trinitroaniline derivatives, especiallyN-(3-nitrophenyl)-2,4,6-trinitroaniline might be used as candidate for the development of new antitumor drugs.Scientific and Technological Research Council of Turkey-TUBITAK [110T754-113Z706]; Balkesir University Scientific Research Project [2017-024]This work was supported by Scientific and Technological Research Council of Turkey-TUBITAK grant numbers 110T754-113Z706, and Balkesir University Scientific Research Project Grant Number 2017-024
