1,721,144 research outputs found

    APPLICATION OF CLUSTER ANALYSIS TO HEMODIALYSIS PATIENTS AFFECTED BY COVID-19: STRATIFICATION ON LONGITUDINAL DATA

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    Collection of data used to calculate and validate cluster analysis on two populations of hemodialysis patients affected by COVID-19

    Further characterisation of Hb Okazaki [b93 (F8) Cys-Arg], a rare hemoglobin variant found in a family from Naples, Italy.

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    Hb Okazaki [β93(F8)Cys-Arg], was first described in 1984 as unstable hemoglobin variant having high oxygen affinity but normal phenotype, and appearing by isoelectric focusing of the hemolysate, under the Author's analytical conditions, as a sharp band migrating near to the position of HbA. 1 We have encountered this variant in the course of an hemoglobinopathy survey, in three members of an italian family (from Naples)

    Muscle protein turnover and low-protein diets in patients with chronic kidney disease

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    Adaptation to a low-protein diet (LPD) involves a reduction in the rate of amino acid (AA) flux and oxidation, leading to more efficient use of dietary AA and reduced ureagenesis. Of note, the concept of 'adaptation' to low-protein intakes has been separated from the concept of 'accommodation', the latter term implying a decrease in protein synthesis, with development of wasting, when dietary protein intake becomes inadequate, i.e. beyond the limits of the adaptive mechanisms. Acidosis, insulin resistance and inflammation are recognized mechanisms that can increase protein degradation and can impair the ability to activate an adaptive response when an LPD is prescribed in a chronic kidney disease (CKD) patient. Current evidence shows that, in the short term, clinically stable patients with CKD Stages 3-5 can efficiently adapt their muscle protein turnover to an LPD containing 0.55-0.6 g protein/kg or a supplemented very-low-protein diet (VLPD) by decreasing muscle protein degradation and increasing the efficiency of muscle protein turnover. Recent long-term randomized clinical trials on supplemented VLPDs in patients with CKD have shown a very good safety profile, suggesting that observations shown by short-term studies on muscle protein turnover can be extrapolated to the long-term period

    Kidney Transplantation in a Patient Affected by Sickle Cell Trait: A Case Report and State-of-the-Art Review

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    Chronic kidney disease (CKD) is a common feature of sickle cell disease (SCD). The awareness of the clinical presentation and renal involvement in patients affected by hemoglobinopathies is greatly needed. Patient management is particularly complex, especially with kidney transplantation. We, therefore, report the case of a 56-year-old patient affected by sickle cell trait who underwent kidney transplantation. This case will underline all the various challenges the nephrologist must face in this clinical setting and their management
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