389 research outputs found
Exploiting noise in array CGH data to improve detection of DNA copy number change-3
No full text<p><b>Copyright information:</b></p><p>Taken from "Exploiting noise in array CGH data to improve detection of DNA copy number change"</p><p></p><p>Nucleic Acids Research 2007;35(5):e35-e35.</p><p>Published online Jan 2007</p><p>PMCID:PMC1994778.</p><p>© 2007 The Author(s).</p
Log() versus log for the data of the 6 chromosomes of the 385 k oligo array datasets
No full text<p><b>Copyright information:</b></p><p>Taken from "Exploiting noise in array CGH data to improve detection of DNA copy number change"</p><p></p><p>Nucleic Acids Research 2007;35(5):e35-e35.</p><p>Published online Jan 2007</p><p>PMCID:PMC1994778.</p><p>© 2007 The Author(s).</p> The red diamond is for the tumor case, while the black circle is for the normal case. The solid black and dashed red lines are straight lines fitted by linear least squares regression. There are no aberrations in chromosomes 19 and 20. The Hurst parameters are obtained as the slopes of the straight lines, which are indicated in the figure
The 385 k oligo array data for () chromosome 1, normal; () chromosome 1, tumor; () chromosome 8, normal; () chromosome 8, tumor
No full text<p><b>Copyright information:</b></p><p>Taken from "Exploiting noise in array CGH data to improve detection of DNA copy number change"</p><p></p><p>Nucleic Acids Research 2007;35(5):e35-e35.</p><p>Published online Jan 2007</p><p>PMCID:PMC1994778.</p><p>© 2007 The Author(s).</p> The right column ones are the corresponding data processed by the proposed method described in Exploiting noise to improve deflection of aberrations from array CGH data. The negative peak in () contains six sample points
Author Correction: Transcript expression-aware annotation improves rare variant interpretation
No full textIn this Article, author Marquis P. Vawter was missing from the Genome Aggregation Database Consortium list. They are associated with the affiliation: ‘Department of Psychiatry & Human Behavior, University of California Irvine, Irvine, CA, USA’, and contributed to the generation of the primary data incorporated into the gnomAD resource. The original Article has been corrected online
Utility of endogenous creatinine clearance as a measure of renal function in mice
No full textUtility of endogenous creatinine clearance as a measure of renal function in mice.BackgroundThe use of endogenous plasma creatinine levels and creatinine clearance as a tool to evaluate renal function in mice has come under scrutiny as prior studies have reported that the Jaffé alkaline picrate method grossly overestimates true plasma creatinine in mice. As members of the NIDDK Animal Models of Diabetic Complications Consortium (AMDCC), we evaluated the performance and feasibility of an alternative high-performance liquid chromatography (HPLC)-based method for standard determination of plasma creatinine and creatinine clearance in mice. Our purpose was to develop a simple method that provides a reliable, reproducible, and sensitive assay for small volumes (<25 μL) of mouse plasma and sera.MethodsWe compared creatinine clearance measured by HPLC with the Jaffé method and HPLC creatinine clearance with inulin clearance [fluoroscein isothiocyanate (FITC) inulin in an osmotic pump implanted in mouse] in C57BL/6J mice. Different groups of mice underwent either one of two protocols. Protocol A included dietary intervention with normal, low salt plus enalapril, or high salt. Protocol B induced diabetes using streptozotocin.ResultsFirst, mean plasma creatinine levels were significantly lower (P < 0.0001) by HPLC (0.128 ± 0.026mg/dL) vs. Jaffé (0.4 ± 0.12mg/dL) for mice on a normal diet. Urine creatinine concentrations measured by HPLC were 10% lower than by Jaffé (P < 0.01). Second, mean creatinine clearance by HPLC for mice on a normal diet was 255 ± 68 μL/min. Mice on low salt diet plus enalapril had reduced creatinine clearance (72.8 ± 24.2 μL/min) while mice on high salt diet had an elevated creatinine clearance (355 ± 105 μL/min). Third, diabetic mice (19 to 24weeks of diabetes) exhibited hyperfiltration as creatinine clearance was 524 ± 214 μL/min whereas nondiabetic age/gender-matched mice showed a mean creatinine clearance of 206 ± 41 μL/min. Finally, significant correlation was demonstrated for creatinine clearance by HPLC vs. inulin clearance (R = 0.643; P < 0.001).ConclusionHPLC is highly accurate, much more sensitive and specific than the Jaffé method for plasma creatinine measurements in mice. Creatinine clearance in mice measured by HPLC reflects changes in renal function induced by diet and diabetes
Number of studies, SNPs and genes by phenotype for all eligible studies.
No full text*<p>includes a 4-SNP haplotype.</p
List of genes from all studies that showed three-way and four-way overlaps across CVD-related phenotypes.
No full text<p>BP, blood pressure; CAD, coronary artery disease, T2D, type 2 diabetes.</p
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