70 research outputs found
Physical and Behavioral Health Needs of Refugee Women Resettled in the United States
No full textThe United States has offered resettlement to more than 3 million refugees who present a high risk for physical and behavioral health problems. Women comprise more than half the resettled refugees and are more vulnerable to these problems. However, more information is needed on the physical and behavioral health needs of resettled refugee women. This three-paper dissertation provides information regarding the physical and behavioral health needs of refugee women resettled in the United States. Paper 1 is a systematic review of factors related to behavioral health problems among refugee women resettled in the United States and the challenges presented by these behavioral health problems. Paper 2 is a qualitative study that examines the physical and behavioral health needs and challenges to accessing and utilizing health and behavioral health services among refugee women resettled in the United States. Paper 3 is the analysis of a nationally representative cross-sectional dataset, The New Immigrant Survey (NIS-2003-1), and examines the group differences in physical and behavioral health needs and service utilization of resettled refugee women from rural and urban origins and compares the findings with those for resettled refugee men. Findings suggest that both pre-migration trauma and post-migration stressors are risk factors for poor behavioral health outcomes. In addition, approaches to address these behavioral health problems must be culturally appropriate. Findings also suggest a need for examining the differences between refugee subgroups such as those belonging to rural and urban origins as needs for these groups may differ. Implications related to understanding the behavioral health needs of resettled refuge women in a cultural context and addressing these needs in culturally appropriate ways are discussed.Doctor of Philosoph
Enhanced Antioxidant and Anticancer Potential of Artemisia carvifolia Buch Transformed with rol A Gene
No full textSecondary metabolites have been shown to possess a range of biological functions. Flavonoids, due to their ability to scavenge ROS, are famous antioxidants. The plants of Artemisia species are rich sources of flavonoids; however, the amount of these metabolites is less. In the current study, the flavonoid content was detected and then enhanced by genetically modifying the Artemisia carvifolia Buch with Agrobacterium tumefaciens strain GV3101 carrying rol A gene. The transformation of rol A gene was confirmed with PCR and the gene copy number was confirmed by Southern blot analysis. The HPLC analysis revealed the presence of catechin (3.19 ug/mg DW) and geutisic acid (2.22 ug/mg DW) in transformed plants, unlike wild-type plants. In transformed plants, all detected flavonoids (vanillic acid, rutin, catechine, gallic acid, syringic acid, caffeic acid, coumaric acid, geutisic acid, ferulic acid, and cinnamic acid) were increased up to several folds. Real-time qPCR revealed the higher expression levels of the genes for flavonoid biosynthesis enzymes phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS) in plants transformed with rol A genes, as the expression levels were increased up to 9–20-fold and 2–6-fold, respectively. The rol A transgenic lines T3 and T5 carrying two copies of rol A gene, particularly showed higher expression of both PAL and CHS gene, with the highest expression in T3 line. The transgenic lines demonstrated an average increase of 1.4-fold in the total phenolic content and 1–2-fold in the total flavonoid content as compared to wild-type plants. Total antioxidant capacity and total reducing power were increased up to an average of 1–2-fold and 1.5–2-fold respectively, along with increased free radical scavenging ability. Furthermore, the rol A gene transgenics were found to have much greater cytotoxic capacity than the A. carvifolia wild-type plant against the MCF7, HeLA, and HePG2 cancer cell lines. Current findings show that the rol A gene effectively increases the flavonoid content of A. carvifolia Buch, boosting the plant’s capacity as an antioxidant and an anticancer. This is the first-ever report, demonstrating the genetic transformation of Artemisia carvifolia Buch with rol A gene
In silico screening of Hippophae rhamnoides polyphenols targeting the RhoA protein as a potential liver cancer treatment
No full textالملخص: أهداف البحث: نظرا لارتباط اشارات بروتينات ''آر اتش أو جي تي بيز'' المضطربة بسرطانات متعددة، يمكن بحثها كهدف محتمل لعلاجات سرطان الكبد. تعتبر نبتة العليق البحري من النباتات الطبية المهمة الموجودة في جبال قراقرم. ويعتقد باحتوائها على مركبات متعددة الفينول قادرة على تثبيط بروتين ''آر اتش أو – أ''، مما قد يوفر تاثيرات مضادة لسرطان الكبد. طرق البحث: تم تحديد المركبات متعددة الفينول في المستخلص الميثانولي للعليق البحري باستخدام التحليل الكروماتوغرافي السائل عالي الكفاءة ثم فحصها للتحري عن امكانياتها المضادة للسرطان عبر الارساء الجزيئي ومحاكاة الديناميكا الجزيئية ضد بروتين ''آر اتش أو – أ''. تم تحديد قيم الانحراف المتوسط الجذري التربيعي وقيم تقلب الجذر المتوسط المربع لكل مركب مختار، تبعها تحليل خصائص الامتصاص والتوزيع والتمثيل الغذائي والإفراز والسمية. النتائج: وجدت المركبات متعددة الفينول حمض الغاليك وحمض الساليسيليك وحمض الكافيك والكيمفيرول والروتين والكيرستين والكومارين وحمض الفيروليك وحمض السينابيك وحمض النبق وحمض الفانيليك وحمض الكلوروجينيك في المستخلص الميثانولي للعليق البحري. بناء على قاعدة ليبنسكي الخماسية ودرجة فينا وحجم التجويف، تم اختيار خمسة روابط لمزيد من البحث حيث تظهر خصائص ملحوظة. وفقا لذلك، تبين حمض الكافيك كمركب بارز مع خصائص امتصاص وتوزيع وتمثيل غذائي وطرح وسمية جذابة ودرجة ارساء ونتائج محاكاة ديناميكية جزيئية مثالية. الاستنتاجات: نظرا لبقائه سليما وارتباطه ببنية البروتين طوال فترة المحاكاة، مما يدل على تفاعل قوي بين البروتين والرابط ويشير لتاثير تثبيطي محتمل، قد يمتلك حمض الكافيك القدرة العظمى على تثبيط بروتين ''آر اتش أو – أ''. وبالتالي، مطلوب مزيد من البحث لدراسة حمض الكافيك كخيار دوائي محتمل للتطوير الدوائي المستقبلي. Abstract: Objective: Because aberrant Rho GTPase signaling has been associated with multiple cancers, it was investigated as a potential target for liver cancer treatment drugs. The important medicinal plant Hippophae rhamnoides, found in the Karakoram Mountains, is believed to contain polyphenols that inhibit RhoA protein, thus potentially eliciting effects against liver cancer. Methods: Polyphenols were identified in the methanolic extract of H. rhamnoides with HPLC, then screened for their anticancer potential against the RhoA protein through molecular docking and molecular dynamic simulations. The RMSD and RMSF values for each selected compound were determined, and ADMET characteristics were analyzed. Results: The polyphenols gallic acid, salicylic acid, caffeic acid, kaempferol, rutin, quercetin, coumarin, ferulic acid, sinapic acid, HB acid, vanillic acid, and chlorogenic acid were found in the methanolic extract of H. rhamnoides. On the basis of Lipinski's rule of five, the Vina score, and the cavity size, we chose five ligands with favorable features for further research. Caffeic acid was the most promising compound, on the basis of favorable ADMET qualities, and the best docking score and MD simulation results. Conclusion: Caffeic acid remained intact and bound the protein structure throughout the simulation run, thus demonstrating a robust interaction between the protein and ligand, and indicating a possible inhibitory effect. Therefore, this compound might have the greatest ability to inhibit the RhoA protein. Further research is required to examine caffeic acid as a potential medication option for future drug development
Critical Race Theory. Impact on Black Minority Ethnic Students within Higher Education
No full textThis book is an attempt to address the notion of Critical Race Theory (CRT) and the underlying parallels with the experiences of Black Minority Ethnic Students (BMEs) under the guise of Widening Participation policies and practices within the realms of Higher Education Institutions (HEIs). The book attempts to explore and compare the post entry academic and social inclusion concepts for BME non-traditional students. The author carried out an extensive level of investigation through her PhD titled “Critical Race Theory A Phenomenological Approach to Black Minority Ethnic Students within Higher Education Institutions”. Moreover, the author within the PhD work identified the habitus structuring models and the academic and social constraints applied within HEIs. This book attempts to illustrate the impact of CRT upon the recruitment, retention, race and racism, learning and teaching themes which are embedded within HEIs. Themes at macro level, meso and micro levels are investigated
Effects of night shift working on some immunological, prostate specific antigen, cortisol level and malondialdehyde in male nurses at Hawler city
No full text
Critical Race Theory: Impact on Black Minority Ethnic Students within Higher Education
No full text“This book arrives at a timely moment. The resurgence of the Black Lives Matter movement in the wake of widespread shock felt across the world over the murder of George Floyd at the hands of the police in the US has triggered a renewed concern with race equality and encouraged organisations, including universities, to reflect on what they are doing to address this issue. While we shall have to wait to see whether fine words are translated into effective actions, there is little doubt that universities are currently more willing to listen to BME voices.”– Professor Andrew Pilkington, University of Northampton, UK.“Historically, CRT follows the notion that there is considerable White bias evident in education and society generally (Bimper, 2017). Studies carried out by Ladson Billings believe that there is clear marginalisation regarding students coming from a BME background and in particular, those students for whom English is not their first language (Carrera, 2019). The author further examined the start of the movement for CRT. CRT began when a small group of activists wanted to understand better race, racism and power (Allen, 2017). The first real CRT movement began by focusing their attention on issues relating to conventional civil rights and ethnic study discourses which existed. They began by really questioning the liberal order addressing equality theory, legal reasoning, rationalism and the fundamental principles of constitutional law in America (Dixon, James, & Frieson, 2018). Regardless of the fact that CRT originated from a movement within Law it did, however, move beyond that discipline. The author further established within her research that educators in the main link themselves to CRT quite holistically (Garcia & Velez, 2018). Educational theorists apply CRT quite loosely to HEIs under the guise of school discipline and hierarchy, tracking, controversies over curriculum and history, IQ and achievement testing. Educational theorists do consider and associate CRT and endeavour to use its core principles to change the social situations present in society today.”ContentsCHAPTER 1 – IntroductionCHAPTER 2 – Critical Race Theory An Educational ConstructCHAPTER 3 – Research MethodologyCHAPTER 4 – Academic AttainmentCHAPTER 5 – Black Minority Ethnic ExperiencesCHAPTER 6 – The Societal CurriculumCHAPTER 7 – Government StrategyCHAPTER 8 – Thematic AnalysisCHAPTER 9 – Discussion and Theorising the FindingsCHAPTER 10 – Conclusions and Recommendation
Longitudinal patterns of behavioral, emotional, and social difficulties and self-concept in adolescents with a history of specific language impairment
No full textPurpose: This study explored the prevalence and stability of behavioral difficulties and self-concepts between 8 and 17 years in a sample of children with a history of specific language impairment (SLI). We investigated whether earlier behavioral, emotional and social difficulties (BESD), self-concepts, language, and literacy abilities predicted behavioral difficulties and self-concepts at 16/17 years.
Method: In this prospective longitudinal study, 65 students were followed up with teacher behavior ratings and individual assessments of language, literacy, and self-concepts at 8, 10, 12, 16, and 17 years.
Results: The students had consistently higher levels of five domains of BESD, which had different trajectories over time, and poorer scholastic competence, whose trajectory also varied over time. Earlier language ability did not predict later behavioral difficulties or self-concepts but the prediction of academic self-concept at 16 by literacy at 10 years approached significance.
Conclusions: We demonstrate the importance of distinguishing domains of behavioral difficulties and self-concept. Language, when measured at 8 or 10 years, was not a predictor of behavior or self-concepts at 16 years, or of self-concepts at 17 years. The study stresses the importance of practitioners addressing academic abilities and different social-behavioral domains in delivering support for adolescents with SLI
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