1,721,075 research outputs found
How should musculoskeletal biopsies be performed?
No full textBiopsy refers to tissue sampling for histological examination, diagnosis, classification, and grading of a tumor. The goal of biopsy is to obtain a diagnostic tissue sample without complications, tumor spread, and compromise of future treatments.1,2 As a rule, all lesions should be biopsied as if they were malignant,2,3 and all soft tissue masses 3 cm or larger in diameter or growing lesions should be biopsied.2,4 Biopsy for musculoskeletal tumors can be closed (percutaneous) or open (incisional or excisional). Closed biopsy can be performed with a fine needle (fine-needle aspiration biopsy) or a core needle, and can be imaging guided or not. This editorial discusses the techniques, principles, and errors of biopsies for musculoskeletal tumors from radiologists’ and orthopedic surgeons’ perspectives
Imaging features of primary tumors of the hand
No full textMusculoskeletal tumors of the hand are a rare entity and are divided into skeletal and soft tissue tumors. Either category comprises benign and malignant or even intermediate tumors. Basic radiology allows an optimal resolution of bone and related soft tissue areas, ultrasound and more sophisticated radiologic tools such as scintigraphy, CT and MRI allow a more accurate evaluation of tumor extent. Enchondroma is the most common benign tumor affecting bone, whereas chondrosarcoma is the most commonly represented malignant neoplasm localized to hand bones. In the soft tissues, ganglions are the most common benign tumors and epithelioid sarcoma is the most frequently represented malignant tumor targeting hand soft tissues. The knowledge regarding diagnostic and therapeutic management of these tumors is often deriving from small case series, retrospective studies or even case reports. Evidences from prospective studies or controlled trials are limited and for this lack of clear and supported evidences, data from the medical literature on the topic are controversial, in terms of demographics, clinical presentation, diagnosis, prognosis and therapy. The correct recognition of the specific subtype and extension of the tumor through first line and second line radiology is essential for the surgeon, in order to effectively direct the therapeutic decisions
Porous Tantalum implants in tumor surgery of the pelvis and lower extremities
No full textPorous Tantalum implants in tumor surgery of the pelvis and lower extremitie
Desarthrodesis and Prosthetic reconstruction of the knee after resection of bone tumors
No full textDesarthrodesis and Prosthetic reconstruction of the knee after resection of bone tumor
Corso di insegnamento SITOP: “Inquadramento clinico ed epidemiologico delle neoplasie muscoloscheletriche dell’età pediatrica”
No full textInquadramento clinico ed epidemiologico delle neoplasie muscoloscheletriche dell’età pediatric
Giovanni Boccaccio biografo "ravennate" di Dante
No full textIl saggio si concentra sulla precoce fortuna editoriale della biografia dantesca del Boccaccio, e specie sullo straordinario omaggio all'ultimo rifugio ravennate, posto in sapiente contrasto con l'invettiva antifiorentina, che connotava l'appassionata prima stesura del "Trattatello in laude di Dante"
L’uso della megaprotesi modulari nella chirurgia di revisione: sopravvivenza degli impianti primari e secondari
No full textL’uso della megaprotesi modulari nella chirurgia di revisione: sopravvivenza degli impianti primari e secondar
Current treatment considerations for osteosarcoma metastatic at presentation
No full textApproximately one-fourth of osteosarcoma patients have metastases at presentation. The best treatment options for these patients include chemotherapy, surgery, and radiotherapy; however, the optimal scheme has not yet been defined. Standard chemotherapy for osteosarcoma metastatic at presentation is based on high-dose methotrexate, doxorubicin, and cisplatin (the MAP regimen), with the possible addition of ifosfamide. Surgical treatment continues to be fundamental; complete surgical resection of all sites of disease (primary and metastatic) remains essential for survival. In patients whose tumors do not respond to neoadjuvant chemotherapy, early surgical resection of the primary tumor with limb-salvage surgery or amputation and multiple metastasectomies, if feasible, after the completion of adjuvant chemotherapy is a reasonable option, as the reduction of the tumor volume could probably increase the effect of chemotherapy. Advanced radiotherapy techniques, such as carbon ion radiotherapy and stereotactic radiosurgery, and molecular targeted chemotherapy with drugs such as pazopanib or apatinib have improved the dismal prognosis, especially for patients who are medically inoperable or who refuse surgery. Given that the presence of metastatic disease at diagnosis of a patient with osteosarcoma is a poor prognostic factor, a multidisciplinary approach by surgeons, medical oncologists, and radiotherapists is important
- …
