133 research outputs found
Friends of the Greenwood Library Presents David Baldacci
No full textOn April 3, 2009, the Friends of the Janet D. Greenwood Library hosted its spring event, which featured an evening with bestselling novelist David Baldacci. Baldacci spoke with guests during the social hour, provided a presentation to a crowd of almost 200 people, and then concluded the evening with a book signing. During his presentation, Baldacci addressed a captive audience as he discussed his many experiences related to becoming a successful writer. He reinforced the fact that he is a fantastic storyteller by sharing some amusing stories related to his career as a novelist. An Evening With Bestselling Novelist David Baldacci The author also spoke about his work in promoting literacy through the “Wish You Well” Foundation and by partnering with Feeding America in Feeding Body & Mind. At the close of his presentation, the audience rewarded Baldacci with enthusiastic applause. Longwood’s Barnes & Noble provided two of Baldacci’s newest novels, Divine Justice and The Whole Truth, for the book signing that followed the presentation. This memorable evening was enjoyed by all of the library’s guests
Right elbow arthropathy in a patient with severe haemophilia A
No full textA 56‐year‐old male had been diagnosed with severe haemophilia A at the age of one year (missense mutation, exon 10, variant NM_000132.3c.1537+1G). He had been treated on demand with plasma‐derived factor VIII (pdFVIII) concentrate for most of his life; he was not compliant with prophylaxis and attended the clinic only when he thought it was strictly necessary. In April 2017 he underwent an orthopaedic assessment, which showed severe arthropathy of both elbows, knees and ankles. In August 2017, he attended the clinic with a major haemarthrosis of the right elbow, which had not resolved with self‐medication. On physical examination, the right elbow was deformed with multidirectional laxity; paradoxically the range of motion was preserved. An X‐ray of the right elbow showed severe arthropathy with complete joint dislocation (upper images). There were also widespread areas of erosion and absorption of the articular surfaces; these were confirmed on computed tomography (CT) scanning (lower left image). The patient was treated for six days with pdFVIII concentrate at a dosage of 50 U/kg/day, and then the frequency of infusions was decreased to every other day. After the acute phase, he continued with pdFVIII 40 U/kg every other day with continued clinical improvement. A peripherally inserted central catheter was used to improve compliance with intravenous infusions. In April 2018 a switch was made to extended half‐life FVIII concentrate (recombinant FVIII‐Fc fusion protein, rFVIII‐Fc, efmoroctocog alpha) to reduce the frequency of infusions. Thereafter the patient accepted prophylaxis with rFVIII‐Fc, at a dosage of 50 U/kg every 96 h, with a FVIII trough level of approximately 10% and stable joint status.
Such severe joint damage is now uncommon in patients with haemophilia A. Our patient is a reminder of the possible consequences if prophylaxis is either unavailable or is not accepted by the patient
Re-enactment e altre storie. Dall’archivio alla contro-narrazione per immagini nell’arte contemporanea
No full textThis text is intended to serve as an introduction to ‘re-enactment’, one of the key concepts of the research on Visual Errancy. The Wandering Image and Its Multiple Temporalities that the author is conducting at ICI Berlin as part as the biennial core project ERRANS, in Time (2016-2018). By ‘visual errancy’ Baldacci means the travelling of certain images or forms over time, which contemporary artists appropriate by grasping them from the archives tout court, as well as the archive understood in a broader sense, as a heterotopic space where all cultural images (past, present, future, utopian...) potentially converge and remain in a state of flux. This appropriation is then followed by a reactivation – which usually also undergoes a process of manipulation and/or migration on different media and in new contexts – providing the images with other values, meanings, and conformations. It is in this way that (cultural) history is put in motion and knowledge re-circulated often as a counter-narrative made of ‘chains of images’ that challenges the traditional idea of heritage and at the same time renovates the modalities of conservation, presentation/representation, and distribution. Filipa César’s Conakry (2013) and Rosa Barba’s From Source to Poem (2016) are taken as two representative filmworks to show how the artistic re-enactment and montage of visual material, both appropriated from the archive and produced ex novo, can give rise to ‘other histories’
Immune thrombocytopenia management during COVID‐19 pandemic: An Italian monocentric experience
No full textOver the last 2 years, different cases of immune thrombocytopenia (ITP) in patients affected by SARS‐CoV2 have been reported. The management of SARS‐CoV2 in subjects with simultaneous or previous ITP can be challenging because of the great involvement of the haemostatic system in this viral infection. In this report, we describe the management and outcome of patients with newly diagnosed (ND), chronic and previous ITP, infected by COVID‐19, referred to the Haematology Institute of University Hospital Policlinico Umberto I in Rome. Steroids + immunoglobulins for ND or relapsed ITP and continuation of home therapy for chronic ITP are advised, although further knowledge is required
Direct oral anticoagulants for the treatment of Mondor's disease not responding to low-molecular weight heparin
No full textMondor's disease is a rare condition and usually treated with low-molecular weight heparin and non-steroidal anti-inflammatory drugs. Because of paucity of cases and for the usually spontaneous resolution, there is not a standard treatment strategy and the use of oral anticoagulation in controversial. We reported the efficacy of direct oral anticoagulants in the recurrent Mondor's disease refractory to standard therapy
Editing as a Performative and Collaborative Practice. Ryan Trecartin's Hectic Video Collages
No full textThis contribution examines editing as an art practice focusing on Ryan Trecartin’s work. Trecartin is definitely one of those artists among the younger generations who is experimenting in a more radical and crosswise manner with the new media and the opportunities of using, sharing and mobilizing images offered by the Internet, beyond copyright and the proper citation of “poached” materials. In Trecartin’s videos, images, sounds and words are assembled in a digital hypertext − schizophrenic and hypnotic − of which the artist is the main but not exclusive author. The analysis focuses on central aspects of Trecartin’s practice, such as the supposed re-materialisation of the art object related to the idea of “an Internet of things”; the visual re-codification that generates new aesthetic standards, such as the so-called “post-Internet style”; and co-working as a contemporary art practice and remedy to the “death of the author” that was pessimistically theorised throughout the 20th and 21st century
La ricerca empirica in pedagogia
No full textAccording to the author the pedagogical research has two convoys: the first epistemological (theoretical and historical), the other praxeology (experimental and empirical). Traveling together these two trains offer us the opportunity to see the face of critical pedagogy, or the reflexive dimension of doing research in education that translates better to the concept of action ricerca-azione. The most interesting aspect that emerges from this investigation is that the investigation is never separated from the ‘action and results that follow are never objective and definitive
Oral anticoagulant therapy in Italian patients 80 yr of age or older with atrial fibrillation: a pilot study of low vs. standard PT/INR targets.
No full textBACKGROUND:
Oral anticoagulation therapy (OAT), which aims to prevent thromboembolism in patients with atrial fibrillation (AF), is underused in subjects who are over the age of 80 yr because of the associated bleeding risk. The aim of this study was to evaluate the efficacy and safety of OAT with low (2.0) vs. standard (2.5) PT/international normalised ratio (INR) targets in patients over the age of 80.
MATERIALS AND METHODS:
Of 233 patients aged 80 yr or older with AF on OAT, 58 had unstable PT/INR values and achieved reduced targets. These patients were enrolled as a group (A) in a case-control study and were treated with a low (2.0) PT/INR target. They were compared with a second group (B) of 58 additional patients who were matched for age and CHADS scores and treated with a standard (2.5) PT/INR target. Group A OAT parameters were also compared before and after the PT/INR reduction. The time in the therapeutic range (TTR%), PT/INR values >5, haemorrhages and strokes were prospectively evaluated in the two groups after 2 yr of follow-up.
RESULTS:
Of the 116 enrolled patients, 55 group A and 57 group B patients were evaluated. The TTR was 72.59% in group A and 64.43% in group B (P 5 was 0.68% for group A and 1.42% for group B (P 5 (1.72% vs. 0.68%; P < 0.001).
CONCLUSIONS:
A low PT/INR target seems effective and safe in Italian patients with AF over the age of 80. Further trials are needed to confirm the hypothesis generated by this study
Satisfaction, quality of life and therapy adherence assessment in real life patients transitioning from vitamin K antagonists to direct oral anticoagulants
No full textAnticoagulant therapy has undergone a significant change since direct oral anticoagulants (DOACs) introduction. Their obvious advantages including the fixed dose, the few interactions and less frequent controls, have made them the first choice anticoagulant therapy. More and more patients have therefore switched from therapy with vitamin K antagonists (VKAs) to DOACs. Aim of our study was to assess the satisfaction, quality of life (QoL) and therapy adherence of patients who switched from VKA to DOACs therapy. This single center study evaluated satisfaction and QoL of 107 patients who switched from VKA to DOACs therapy through Anti-Clot Treatment Scale and SF-36 respectively. The questionnaires were administered before therapy change, after 3 months of DOACs therapy and then annually. We also evaluated DOACs therapy adherence with a questionnaire administered each visit and through the measures of DOACs plasma levels. Patients' satisfaction and QoL were high during VKA therapy, but with DOACs we observed an improvement after the first 3 months and then maintained over the time of DOACs therapy. DOACs adherence was excellent, also confirmed by DOACs plasma levels
Different regimens of prophylaxis treatment in young severe hemophilia A patients: comparisons on efficacy, FVIII consumption, and therapy compliance
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