117,914 research outputs found
Il contributo dell'archeologia stratigrafica alla conoscenza di Cimitile
No full text1) Il contributo dell’archeologia stratigrafica alla conoscenza di Cimitile, in Cimitile e Paolino di Nola, la tomba di S. Felice e il centro di pellegrinaggio: trent’anni di ricerche. Atti della giornata tematica dei Seminari di Archeologia Cristiana (École française de Rome, 9 marzo 2000), a cura di H. BRANDENBURG – L. ERMINI PANI, Città del Vaticano, febbraio 2003, pp. 281-294
Toward a complex spatial history? Tracing the (non-stationary) economic disparities between northern and southern Italy
No full textThe short-term economic dynamics of local districts in light of the increasing regional disparities in Italy is examined. A multidimensional approach of ‘economic development’ is assumed and contextual variables such as the share of agriculture and industry in total value added, labour productivity by sector, per-capita and per-worker value added, have been evaluated jointly adopting an exploratory analysis that includes inferential and non-parametric statistics, integrated in appropriate geographical information systems. Economic dynamics of local districts in two separate phases (mid-1990s and mid-2000s) of the recent Italian development path were evaluated. This approach was preferred to more traditional methodologies centred on convergence analysis of income levels and change over time, allowing a refined discussion of the increasingly complex geography of economic development and ʼnewly emerging’ regional divides. The factors supposed to have a prominent role in such dynamics have been also investigated. The empirical results suggest that the traditional North-South gap consolidated in recent years. Coastal-inland and urban-rural gradients were crucial especially in economically disadvantaged districts, outlining a latent transition from agriculture and state-driven industry towards services with low-value added. The persistence of North-South disparities allowed identification of ‘structural’ dimensions of change as a possible target for integrated social policies
Approximate Entropy of Spiking Series Reveals Different Dynamical States in Cortical Assemblies
No full textSelf-organized criticality theory proved that information transmission and computational performances of neural networks are optimal in critical state. By using recordings of the spontaneous activity originated by dissociated neuronal assemblies coupled to Micro-Electrode Arrays (MEAs), we tested this hypothesis using Approximate Entropy (ApEn) as a measure of complexity and information transfer. We analysed 60 min of electrophysiological activity of three neuronal cultures exhibiting either sub-critical, critical or super-critical behaviour. The firing patterns on each electrode was studied in terms of the inter-spike interval (ISI), whose complexity was quantified using ApEn. We assessed that in critical state the local complexity (measured in terms of ApEn) is larger than in sub-and super-critical conditions (mean ± std, ApEn about 0.93 ± 0.09, 0.66 ± 0.18, 0.49 ± 0.27, for the cultures in critical, sub-critical and super-critical state, respectively—differences statistically significant). Our estimations were stable when considering epochs as short as 5 min (pairwise cross-correlation of spatial distribution of mean ApEn of 94 ± 5%). These preliminary results indicate that ApEn has the potential of being a reliable and stable index to monitor local information transmission in a neuronal network during maturation. Thus, ApEn applied on ISI time series appears to be potentially useful to reflect the overall complex behaviour of the neural network, even monitoring a single specific location
Evolutionary adaptations to risk of cancer: Evidence from cancer resistance in elephants
No full textParadoxes can be intellectually challenging and illuminating. The eponymous Peto paradox originated approximately 40 years ago when Peto, along with his colleagues Doll and Cairns, highlighted the observation that cancer risk does not appear to scale with size in the animal kingdom.1,2 The underlying premise was that more cell division (to make and sustain a larger animal) along with longer life span might be expected to carry a proportionally greater mutational and malignancy risk
Un enigma difficile da risolvere: come identificare il paziente a rischio cardiovascolare.
No full textThe Application of Long-Read Sequencing to Cancer
No full textCancer is a multifaceted disease arising from numerous genomic aberrations that have been identified as a result of advancements in sequencing technologies. While next-generation sequencing (NGS), which uses short reads, has transformed cancer research and diagnostics, it is limited by read length. Third-generation sequencing (TGS), led by the Pacific Biosciences and Oxford Nanopore Technologies platforms, employs long-read sequences, which have marked a paradigm shift in cancer research. Cancer genomes often harbour complex events, and TGS, with its ability to span large genomic regions, has facilitated their characterisation, providing a better understanding of how complex rearrangements affect cancer initiation and progression. TGS has also characterised the entire transcriptome of various cancers, revealing cancer-associated isoforms that could serve as biomarkers or therapeutic targets. Furthermore, TGS has advanced cancer research by improving genome assemblies, detecting complex variants, and providing a more complete picture of transcriptomes and epigenomes. This review focuses on TGS and its growing role in cancer research. We investigate its advantages and limitations, providing a rigorous scientific analysis of its use in detecting previously hidden aberrations missed by NGS. This promising technology holds immense potential for both research and clinical applications, with far-reaching implications for cancer diagnosis and treatment
Santuari martiriali e centri di pellegrinaggio in Italia fra tarda antichità e alto medioevo
No full text
Studi medievali, nuova serie diretta da V. Crescini, F. Ermini, D. Fedele, D.S. Leicht, E. Levi, L. Suttina & V. Ussani, I (1928)
No full textR. M. Studi medievali, nuova serie diretta da V. Crescini, F. Ermini, D. Fedele, D.S. Leicht, E. Levi, L. Suttina & V. Ussani, I (1928). In: Romania, tome 55 n°218, 1929. pp. 298-302
Analysis of water networks with discontinuous supply flows
No full textIn analyzing water distribution networks hydraulic behavior it is often requested to describe the demand flows, not assigning them values (Demand Driven Analysis), but introducing the nodes relationship between pressures and outflows (Head Driven Analysis).
The computational models usually used are not able to correctly simulate the variations of the flows determined by the pressure conditions in any nodes and, therefore, they are not usable to analyze the aforesaid behaviors.
Instead to employ the Head Driven models, that imposes to define the Q=f(H) relationship in every node, an iterative procedure is applied (Ermini et to the., 2006) that allows to use the traditional EPANET model but recursively correcting the demand flows to satisfy the congruence between demand flows and pressure at every nodes.
A very interesting comparison is showed analyzing the hydraulic behavior of a complex water distribution network (city of Dhaka in Bangladesh), underlining the potentialities of the proposed modeling tool.
Often, particularly in developing countries the rapid growth of the hydraulic consumptions, the lack of adequate water supply and the increasing inefficiency of water distribution systems impose discontinuous hydraulic functioning with demands supplied only in some periods.
In such networks low pressures, irregularly delivered flows and wide spred inefficiencies often occur in many zone of the.
Previous topic are discussed in the present paper referring to the case study of the Dhaka (Bangladesh) distribution network that deals water supply to 4.5-6 milions of inhabitants distributed in an area of about 150 Km2.
The Dhaka network is made of about 1700 Km of pipes, 400 wells and 3 intakes from Gange River.
Actually water requirements are not satisfied so that only 17 m3/s (corresponding to 244-326 l/inhabb•day) are delivered to the users, instead of 25 m3/s (corresponding to 360-480 l/inhab.day) requested. Therefore water has been managed by applying intermittent service in many districts
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