1,722,114 research outputs found
European model for inhabited areas – ERMIN 2
No full textThe European Model for Inhabited Areas (ERMIN) evaluates strategies for the remediation
of inhabited areas contaminated by air-borne radioactive material. The enhancements in the
new version, ERMIN 2, were motivated by the new ICRP recommendations for a system of
radiological protection, and by user feedback. The underlying model has not changed but
the interface has been enhanced to allow the user to easily compare recovery strategies
and to select appropriate countermeasure options within the context of ICRP
recommendations on the residual dose
Kritische Überprüfung der kolorimetrischen Serum-Cholesterin-Bestimmungen
No full textvorgelegt von Ermin WelzlInnsbruck,Univ., Diss., 196
Kritische Überprüfung der kolorimetrischen Serum-Cholesterin-Bestimmungen
No full textvorgelegt von Ermin WelzlInnsbruck,Univ., Diss., 196
Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult
Get PDFErmin is an actin‐binding protein found almost exclusively in the central nervous system (CNS) as a component of myelin sheaths. Although Ermin has been predicted to play a role in the formation and stability of myelin sheaths, this has not been directly examined in vivo. Here, we show that Ermin is essential for myelin sheath integrity and normal saltatory conduction. Loss of Ermin in mice caused de‐compacted and fragmented myelin sheaths and led to slower conduction along with progressive neurological deficits. RNA sequencing of the corpus callosum, the largest white matter structure in the CNS, pointed to inflammatory activation in aged Ermin‐deficient mice, which was corroborated by increased levels of microgliosis and astrogliosis. The inflammatory milieu and myelin abnormalities were further associated with increased susceptibility to immune‐mediated demyelination insult in Ermin knockout mice. Supporting a possible role of Ermin deficiency in inflammatory white matter disorders, a rare inactivating mutation in the ERMN gene was identified in multiple sclerosis patients. Our findings demonstrate a critical role for Ermin in maintaining myelin integrity. Given its near‐exclusive expression in myelinating oligodendrocytes, Ermin deficiency represents a compelling “inside‐out” model of inflammatory dysmyelination and may offer a new paradigm for the development of myelin stability‐targeted therapies
Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology
No full textOligodendrocytes form an insulating multilamellar structure of compact myelin around axons, thereby allowing rapid propagation of action potentials. Despite the considerable clinical importance of myelination, little is known about the molecular mechanisms that enable oligodendrocytes to generate their specialized membrane wrapping. Here, we used microarray expression profiling of oligodendrocyte-ablated mutant mice to identify new glial molecules that are involved in CNS myelination. This effort resulted in the identification of Ermin, a novel cytoskeletal molecule that is exclusively expressed by oligodendrocytes. Ermin appears at a late stage during myelination, and in the mature nerves, it is localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. In cultured oligodendrocytes, Ermin becomes visible in well differentiated MBP-positive cells, where it is concentrated at the tip of F-actin-rich processes (termed "Ermin spikes"). Ectopic expression of Ermin, but not of a mutant protein lacking its actin-binding domain, induced the formation of numerous cell protrusions and a pronounced change in cell morphology. Our results demonstrate that Ermin is a novel marker of myelinating oligodendroglia and suggest that it plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis
The European model for inhabited areas (ERMIN) – developing a description of the urban environment
No full textThe European Model for Inhabited Areas (ERMIN) was developed to explore recovery options
following the contamination of an urban environment with radioactive material. This paper
discusses the user experience of ERMIN and in particular it concentrates on the
development of a description of the urban environment and how that description affects the
output. The user interacts with ERMIN by defining different regions on a map. A region may
be an area in which a particular combination of recovery countermeasures is applied, or
where a particular level of contamination is found, or where there is a particular type of
urban environment. Most of the output from ERMIN is also presented as maps with summary
information that allows the user to compare different countermeasure strategies. ERMIN has
been implemented within two international nuclear accident Decision Support Systems; RODOS
and ARGOS. Both systems have user interfaces that exploit geographic information system
(GIS) technology which complement the ERMIN map based approach
Auswirkungen des Klimawandels auf die Wassertemperatur der Ruetz (Stubaital) und ihr Einfluss auf den Fischbestand der Bachforelle
No full textAnwendung von Feldarbeit, Fernerkundung und Klimadatenanalyse als Methodenkombination zur Detektion von Veränderungen am Wasserregime und deren Einfluss auf den Fischbestand der Bachforelle Ermin Lepirica, BSc.Summary in englischer SpracheMasterarbeit Universität Innsbruck 202
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination
Get PDFIncomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ) mouse model, and in MS. The density of ermin+ oligodendrocytes in the brain was significantly decreased after one week of CPZ exposure (p < 0.02). The relative proportion of ermin+ cells compared to cells positive for the late-stage oligodendrocyte marker Nogo-A increased at the onset of remyelination in the corpus callosum (p < 0.02). The density of ermin-positive cells increased in the corpus callosum during the CPZ-phase of extensive remyelination (p < 0.0001). In MS, the density of ermin+ cells was higher in remyelinated lesion areas compared to non-remyelinated areas both in white- (p < 0.0001) and grey matter (p < 0.0001) and compared to normal-appearing white matter (p < 0.001). Ermin immunopositive cells in MS-lesions were not immunopositive for the early-stage oligodendrocyte markers O4 and O1, but a subpopulation was immunopositive for Nogo-A. The data suggest a relatively higher proportion of ermin immunopositivity in oligodendrocytes compared to Nogo-A indicates recent or ongoing remyelination
Comparison of ermin and Nogo-A expression in de- and remyelinated MS lesion areas.
No full textDensity of ermin+ and Nogo-A+ cells in remyelinated white matter (A) and gray matter (B) MS lesion areas, and demyelinated white matter (C) and gray matter (D) MS lesion areas. A remyelinated white matter MS lesion area single-label immunostained for ermin (E) and Nogo-A (F). White matter remyelinated MS lesion areas double-label immunostained for ermin (DAB, brown) (G-I) and Nogo-A (AP, red-pink) (G), O1 (AP, red-pink) (H), and O4 (AP, red-pink) (I). Arrows: Double-immunopositive cells. Red arrowhead: Cells immunopositve for ermin, Black arrowhead: Nogo-A (A); O1 (H) and O4 (I). A small proportion of oligodendrocytes were double immunopositive for ermin and Nogo-A (G, arrows). Ermin+ cells were not immunopositve for O1 or O4. Scale bar = 50 μm, ****: p 0.05).</p
Auswirkungen des Klimawandels auf die Wassertemperatur der Ruetz (Stubaital) und ihr Einfluss auf den Fischbestand der Bachforelle
No full textAnwendung von Feldarbeit, Fernerkundung und Klimadatenanalyse als Methodenkombination zur Detektion von Veränderungen am Wasserregime und deren Einfluss auf den Fischbestand der Bachforelle Ermin Lepirica, BSc.Summary in englischer SpracheMasterarbeit Universität Innsbruck 202
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