24 research outputs found
A randomized split-face clinical trial analyzing daylight photodynamic therapy with methyl aminolaevulinate vs ingenol mebutate gel for the treatment of multiple actinic keratoses of the face and the scalp
No full textMultidisciplinary focus on methotrexate in psoriatic disesase
No full textThe aim of this focus is to establish the role of methotrexate (MTX) in the treatment of psoriatic disease (PD). Despite the lack of hard evidence, MTX can be regarded as the nonbiological drug of choice for the treatment of peripheral psoriatic arthritis, although its effect on psoriatic dactylitis, enthesitis, and spondylitis needs to be further studied by means of well conducted clinical trials. MTX is effective in improving the skin involvement of PD, and can be used in moderate to severe psoriasis before starting a biological agent. Although rheumatologists consider it relatively safe in PD, dermatologists are very concerned about its toxicity and so, until more definite data are available, precautions should be taken to prevent MTX-induced liver fibrosis and cirrhosis
Narrowband ultraviolet B phototherapy in the treatment of cutaneous graft-versus-host disease in oncohaematological paediatric patients
No full textBACKGROUND: Graft-versus-host disease (GVHD) represents an important complication following allogeneic bone marrow transplantation. In recent years, narrowband ultraviolet B (NB-UVB, 311-313 nm) has been found to be a beneficial adjuvant treatment in patients refractory to first-line immunosuppressive drugs.
OBJECTIVES: The aim of this study is to analyse retrospectively the clinical outcome of 10 GVHD paediatric patients treated with NB-UVB therapy.
PATIENTS AND METHODS: Ten paediatric patients (six girls and four boys: median age 12.5 years, range 4-20) with cutaneous GVHD were enrolled in the study: five patients with chronic GVHD and five patients with an overlap syndrome GVHD. All patients had already been shown to be resistant to first-choice immunosuppressive protocols, and were treated with NB-UVB phototherapy until a clinical remission of skin lesions occurred.
RESULTS: A complete response (absence of lesions) was achieved in 80% of the cases (eight patients) after a median number of 29 treatments, corresponding to a median of 7.5 weeks (52 days) of treatment (range 3-13 weeks), with an average cumulative dose of 28.71 J cm(-2) (range 1.02-70.38 J cm(-2)). Only two patients reported a partial remission (< 18% of body surface area involved). During the follow-up period, a complete remission after 1 year was observed in 75% of patients and after 2 years in 71% of the evaluable patients.
CONCLUSIONS: This study provides evidence that NB-UVB phototherapy represents a valid second-line treatment in paediatric patients affected by GVHD and refractory to immunosuppressive first-line treatmen
Il gioco delle antifrasi nell’incipit della Fiaccola sotto il moggio
No full textThe textual incipit of the second Abruzzo tragedy by Gabriele d’Annunzio, La fiaccola sotto il moggio (1905), defines its character in close relationship with three literary references: the Vangeli (of Luca, Matteo and Marco), the Coefore of Eschilo and La figlia di Iorio (1903; ed. 1904) by the poet himself. The analysis of the first portion of the dramaturgical text shows how, starting from the initial atmospheres, the author loves the game of antiphrastic references with those works, which constitute the filigree of the poetic construction through thematic and conceptual references. Above all, the inverse morality that animates Gigliola, the protagonist, emerges in relation with the evangelical premises contained in the title, as well as the subversion of the tragic order of the classical matrix which also inspires the text
Corrigendum to âResponse to: Mitochondrial neuropathy affects peripheral and cranial nerves and is primary or secondary or bothâ [Neuromuscular Disorders 26/8 (2016) 549](S0960896616302899)(10.1016/j.nmd.2016.06.007)
No full textThe authors regret that the order of the first and last names was listed incorrectly in the above letter. The correct order for the authors' names is: Michelangelo Mancuso, Daniele Orsucci, Corrado Angelini, Enrico Bertini, Claudio Bruno, Valerio Carelli, Giacomo P. Comi, Massimiliano Filosto, Costanza Lamperti, Maurizio Moggio, Tiziana Mongini, Isabella Moroni, Paola Tonin, Antonio Toscano, Gabriele Siciliano, on behalf of the Nation-wide Italian Collaborative Network of Mitochondrial Diseases. Moreover, as this was a letter, only the affiliation of the corresponding author (M. Mancuso) was given. The corresponding author's address is not the affiliation for all other authors except for Daniele Orsucci and Gabriele Siciliano who share the same affiliation: Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy. The authors would like to apologise for any inconvenience caused
Photoinduced dermatitis and oral lichenoid reaction in a chronic myeloid leukemia patient treated with imatinib mesylate
No full textBACKGROUND: Imatinib mesylate (IM) is a phenylaminopyrimidine that represents the first-line treatment for chronic myeloid leukemia (CML), Philadelphia chromosome-positive. It acts as a potent and selective inhibitor of the bcr-abl fusion protein by a competitive inhibition at the adenosine triphosphate-binding site of the enzyme, which leads to the inhibition of tyrosine phosphorylation of the proteins involved in bcr-abl signal transduction. IM is generally well tolerated and usually provokes only mild side effects consisting of nausea, myalgia, edema and muscle cramps.
OBSERVATION: This is a report of a patient affected by CML, who developed a photoinduced dermatitis and an oral lichenoid reaction associated with IM treatment. The lesions were resolved, thanks to the withdrawal of the therapy, and they relapsed after the reintroduction of IM, confirming the drug-induced pathogenesis.
CONCLUSION: Skin changes are the most common non-hematologic side effects to IM treatment and are usually dose dependent. In particular, patients with IM therapy reported a lightening and depigmentation of the skin, that may alter the skin protection against ultraviolet exposure, with a possible subsequent intolerance to sun exposure, as reported in our patient, and higher risk of skin cancer. They are frequently self-limited or easily managed; nevertheless, in some cases, the therapy needs to be discontinued or may only be continued with concomitant oral steroid
Eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient treated with Ruxolitinib
No full textRuxolitinib is a JAK1 and JAK2 inhibitor, approved by the U.S. Food and Drug Administration (FDA) in November 2011, highly effective in the clinical management of myelofibrosis and associated complications (splenomegaly consequent to extramedullary hematopoiesis, cytopenias). We describe a case of Ruxolitinib-induced eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient with myelofibrosis. A 74 year old woman was diagnosed with myelofibrosis in 2013 and was put on Ruxolinitib, without association of other immunosuppresive drugs. This article is protected by copyright. All rights reserved
Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity
No full textHyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. The aim of this study is to investigate homocysteine, folic acid and vitamin B12 levels in a cohort of psoriatic patients and its relationship with the severity of the disease. A retrospective observational study in 98 patients with chronic plaque psoriasis and 98 healthy controls was performed. Total plasma homocysteine level, folic acid, vitamin B12 and PASI index were assessed in every patient. Patients with psoriasis had plasma homocysteine levels higher than controls (57% of cases and 25% of controls; p<0.0001). Folic acid and vitamin B12 plasma levels were lower in psoriatic patients than in controls (p = NS), lower levels of vitamin B12 were found in patients with hyperhomocysteinaemia compared to patients with a normal value of homocysteine (p = 0.0009). The severity of psoriasis assessed according to PASI (19.51+/-16.26) did not directly correlate either with higher levels of homocysteine or with vitamin B12 and folic acid plasma levels. In conclusion, a significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. A significant correlation between hyperhomocysteinaemia and lower vitamin B12 levels, but not folic acid, was evidenced. On the contrary, our data do not correlate the high level of homocysteine with higher PASI scores or psoriasis type, suggesting that homocysteine level can be considered an independent risk factor in psoriatic patients
Francesco Petrarca fra l'arte della regola e la regola d'arte
No full textNel presente contributo si esamina la novità dell'epistolografia petrarchesca in rapporto all'ars dictaminis. Si prendono in considerazione tre punti: 1) i rapporti diretti di Petrarca con l'epistolografia medievale (in particolare con il Boncompagnus di Boncompagno da Signa) e con quella preumanistica di Geri d'Arezzo; 2) l'originalità di Petrarca come scrittore di lettere e progettatore di epistolari; 3) la fortuna delle sue novità presso i contemporanei (in particolare si esaminano i casi di Francesco Nelli, Gabrio Zamorei e Moggio Moggi).In this essay the novelty of Petrarch's letters is examined with regard to the ars dictaminis. Three points are considered: 1) the direct relation between Petrarch and ars dictaminis, (especially with regard to the Boncompagnus of Boncompagno da Signa) and the prehumanistic epistolary of Geri d'Arezzo; 2) the originality of Petrarch as an author of letters and a planner of epistolaries; 3) the success of his innovations among his contemporaries (the cases of Francesco Nelli, Gabrio Zamorei and Moggio Moggi are examined particularly)
Neoplastic and inflammatory skin disorders and serum levels of polychlorinated biphenyls in a population living in a highly polluted area
No full textAlthough polychlorinated biphenyls (PCBs) have been classified as human carcinogens for their association with melanoma, few data are available for other skin lesions
