20 research outputs found
The role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer: Survey results from members of the society of gynecologic oncologists, a 5-year follow-up
No full textThe role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer: Survey results from members of the society of gynecologic oncologists, a 5-year follow-up
No full textDevelopment of a Proficiency-Based Simulation Training Model for Laparoscopic Vaginal Cuff Closure
No full textRole of dose selection in successful interleukin-2 immunotherapy: solving the Goldilock’s Complex
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Low-dose interleukin-2 impairs host anti-tumor immunity and inhibits therapeutic responses in a mouse model of melanoma
No full textNon-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death
No full textSummaryIn light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8+ T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1). Immunotherapy to block PD-1 reverses this loss of anti-tumor CD8+ T cells from the tumor and decreases infection-induced tumor growth. Our findings show that acute non-oncogenic infection can promote cancer growth, raising concerns regarding acute viral illness sequelae. They also suggest an unexpected role for PD-1 blockade in cancer immunotherapy and provide insight into the immune response when faced with concomitant challenges
The Multidimensional Perfectionism Cognitions Inventory–English (MPCI-E): Reliability, validity, and relationships with positive and negative affect
No full textThe Multidimensional Perfectionism Cognitions Inventory (MPCI; Kobori & Tanno, 2004) is a promising new instrument developed in Japan to assess perfectionism cognitions regarding personal standards, pursuit of perfection, and concern over mistakes. The present study examined reliability and validity of the English version of the MPCI, the MPCI-E (Kobori, 2006), in a sample of 371 native English speakers. A confirmatory factor analysis confirmed the MPCI-E’s three-factorial oblique structure. Moreover, correlations with measures of dispositional perfectionism and past-week positive and negative affect provided first evidence of the MPCI-E’s convergent and differential validity. Finally, hierarchical multiple regressions indicated that the MPCI-E showed incremental validity in explaining variance in positive and negative affect above variance explained by dispositional perfectionism. Overall, the findings provide first evidence for the reliability and validity of the MPCI-E as a multidimensional measure of perfectionism cognitions that has the potential to further our understanding of positive and negative cognitions in perfectionism
Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response.
No full textPrior studies suggest that the impaired healing seen in diabetic wounds derives from a state of persistent hyper-inflammation characterized by harmful increases in inflammatory leukocytes including macrophages. However, such studies have focused on wounds at later time points (day 10 or older), and very little attention has been given to the dynamics of macrophage responses in diabetic wounds early after injury. Given the importance of macrophages for the process of healing, we studied the dynamics of macrophage response during early and late phases of healing in diabetic wounds. Here, we report that early after injury, the diabetic wound exhibits a significant delay in macrophage infiltration. The delay in the macrophage response in diabetic wounds results from reduced Chemokine (C-C motif) ligand 2 (CCL2) expression. Importantly, one-time treatment with chemoattractant CCL2 significantly stimulated healing in diabetic wounds by restoring the macrophage response. Our data demonstrate that, rather than a hyper-inflammatory state; the early diabetic wound exhibits a paradoxical and damaging decrease in essential macrophage response. Our studies suggest that the restoration of the proper kinetics of macrophage response may be able to jumpstart subsequent healing stages. CCL2 chemokine-based therapy may be an attractive strategy to promote healing in diabetic wounds
Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response.
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