33 research outputs found
The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes
No full textBackground/aim: This study investigated the effect of proanthocyanidin (PA) against formaldehyde (FA)-induced lipid peroxidation damage and morphological changes in rat testes. Materials and methods: Twenty-one Wistar albino rats were randomized into 3 groups: control, FA, and FA + PA groups. Plasma and tissue malondialdehyde (MDA) and total sialic acid (TSA) levels were measured. Testes tissues were observed by light and electron microscopy. Results: TSA (plasma and tissue) levels decreased and MDA (plasma) significantly increased (P < 0.05) in rats treated with FA compared to the controls. Tissue MDA levels were not significantly different. Several necrotic changes were observed in testes tissues by light and electron microscopy. Disordering in epithelia of seminiferous tubules, vacuolization between germinal epithelium cells, and separated basement membranes were observed by light microscope. Immunopositivity in Leydig cells decreased in the FA group (P < 0.05). In the FA + PA group there were more immune Leydig cells reacting immune-positively than in the FA group (P < 0.05). Ultrastructurally, FA also caused disorganization and loss of mitochondrial cristae, and dilatation in endoplasmic reticulum in testes. Conclusion: The results suggest that PA has a protective effect on FA toxicity in testes.Trakya University Scientific Research Projects Unit [TUBAP - 2009/140]This research was carried out with the financial support of the Trakya University Scientific Research Projects Unit (Project No: TUBAP - 2009/140)
Effects of Masai Barefoot Technology Footwear Compared with Barefoot and Oxford Footwear on Gait
No full textBackground: Shoes, with their biomechanical features, affect the human body and function as clothing that protects the foot. This study aimed to investigate the effects of Masai Barefoot Technology (MBT) shoes on gait in healthy, young individuals compared with bare feet and classic stable shoes. Methods: The study was conducted in 67 healthy females aged 18 to 30 years. All volunteers walked barefoot, in Oxford shoes, and in MBT shoes and were evaluated in the same session. Kinematic gait analyses were performed. The three performances were compared using repeated-measures analysis of variance to study the variance in the groups themselves, and the Friedman and Wilcoxon paired two-sample tests were used for the intragroup comparisons. Results: We found that the single support time and the swing phase ratio increased during walking in MBT shoes compared with walking in stable shoes, whereas the double support ratio, stride length, cadence, gait speed, loading response ratio, and preswing phase ratio decreased. However, it was found that the step and stride length, step width, and gait speed increased and the preswing phase extended during walking in stable shoes compared with walking barefoot. Conclusions: These results support the hypothesis that MBT shoes facilitate foot cycles as they reduce the loading response and the preswing and stance phase ratios
3d Motion Analysis Of Hip, Knee And Ankle Joints During Gait For 7-11 Aged Children
No full textObjective: The purpose of this study is to constitute a normative walking kinematic database and to investigate the differences between 7-11 aged children and between the left and right sides of those age groups. Materials and Methods: Fifty children between the 7 and 11 years old (10 from each age group) participated in this study. The measurements were made with Zebris(C) CMS 70 P 3D motion analysis system. Flexion- extension, abduction-adduction angles of the hip joint, the flexion-extension of the knee and ankle joints and foot rotations for each age group for both sides were recorded. Results: Even all the groups' gait patterns were similar with the literature, 9 years old group has lower knee flexion and higher ankle extensions (p<0.05). Eight and 9 years old groups have higher maximum ankle extension values when compared with the other age groups (p<0.05). Conclusion: Kinematic analysis results of 7 to 11 years old children suggests adult-like gait patterns especially for the hip and knee. These findings stress the importance of age-matched normative data for the kinematic gait analysis
Accessory inferior thyroid artery and internal thoracic artery originating from the thyrocervical trunk
No full textDuring the routine dissection of an 86-year-old Caucasian male cadaver, an accessory inferior thyroid artery originating from the left suprascapular artery was detected. In addition to the existence of inferior and superior thyroid arteries, a third thyroid artery arising from the left suprascapular artery was present at the left of these arteries; this artery was determined as the accessory inferior thyroid artery. Again, the left internal thoracic artery arose from the thyrocervical trunk. The internal thoracic artery originated near the thyrocervical trunk's origin point and descended vertically. The thyrocervical trunk ended near the medial border of the anterior scalene muscle after giving rise to the inferior thyroid, transverse cervical and suprascapular arteries
Investigation of the Protective Effects of Proanthocyanidin and Vitamin E against the Toxic Effect caused by Formaldehyde on the Liver Tissue
No full textWe aimed to investigate of protective role of proanthocyanidin (PA) and vitamin E (vit E) against to toxic effect of formaldehyde (FA). Twenty-eight Wistar albino rats were divided into four groups: control group, rats treated with FA intraperitoneal (i.p.) (10 mg/kg), FA + vit E intragastric (i.g.) (30 mg/kg), and FA + PA i.g. (100 mg/kg). We assayed superoxide dismutase (SOD), glutathione peroxidase (Gpx), myeloperoxidase (MPO) activity and levels of malondialdehyde (MDA) and total sialic acid (TSA) in liver. Liver tissue was taken in order to morphological analysis and hepatocytes apoptosis using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay immunostaining. SOD decreased in FA and increased in FA + vit E and FA + PA (p < 0.05). Gpx didn't change in FA and increased in FA + PA (p < 0.05). No significant variation between the groups was found in MPO activity. MDA increased only in FA and decreased in FA + vit E and FA + PA (p < 0.05). TSA didn't alter in FA and FA + vit E but decreased in FA + PA (p < 0.05). Degeneration in hepatocytes and endothelial cells, cytoplasm losses, vacuolization, picnotic nuclei, and mononuclear cell infiltration were identified in FA. Degeneration in chromatin material, membrane damage in mitochondria and losses in mitochondrial cristae in hepatocytes were observed in FA. We found that partially recovery in liver as a result of FA + vit E and FA + PA. We have concluded that long term use should be investigated for complete explanation of PA's protective effects on FA toxicity. (C) 2014 Wiley Periodicals, Inc
Evaluation of vestibular functions and balance in Edirne Band musicians
No full textBACKGROUND: It has been found that intense noise may affect the peripheral vestibular system and consequently causes problems in balance mechanisms. OBJECTIVE: The aim of this study was to investigate the effects of exposure to chronic noise on vestibular functions and balance in Edirne Band musicians. METHODS: Twenty-two individuals working in the Edirne Band for at least 5 years and a control group of 22 individuals working at Trakya University with similar sociodemographic characteristics were included. The socio-demographic questionnaire was used to inquire about the demographic characteristics of individuals, the ABC Scale to assess how they felt about the balance, and the DHI to determine the quality of life related to dizziness. A 3D ultrasonic system was used to assess the static and dynamic balance of the individuals. RESULTS: There was a statistically significant difference between the band and the control group in terms of longitudinal deviation and self-spin parameters of the Unterberger test, dizziness handicap inventory scores, functional balance according to activity-specific balance confidence scale (p < 0.05). CONCLUSIONS: As a result of our study, it has been shown that the balance, quality of life and vestibular system functions are negatively affected in the band exposed to noise for a long time
Investigation of the effect of digitalisation process of patient files archive on cost and work motivation of employees
No full textBackground One of the most important topics in the process of digital transformation in healthcare services are 'electronic patient records' and 'digital archive' applications.Objectives The study was to create the infrastructure of the digitalisation process of the patient files archive, to compare cost benefit analysis and time study of paper-based archive and digital archive systems, to analyse the change in work motivation of archive employees with the transition process to digital archive.Methods The study carried out in 3 stages. At scanning of patient files stage, hospital archive employees started to scan the files. The 2nd stage of the study was cost calculation and time study. The third stage of the study was evaluation of work motivation of employees. The effect of paper-based archive and digital archive on work motivation was evaluated with a qualitative study.Results As of the study closing date, 222,461 patient files were digitalised. As a result of the cost-benefit analysis, the benefit of the fixtures we bought for the archive was 2.37 times more in the calculation of creating a new additional archive instead. It has been determined that at the end of the digitalisation process, the motivation of patient file archive employees increased, work-related anxiety and their physical problems such as hand hurt decreased, and they felt valued.Conclusion In this study, it has been proven that digital archives provide advantages in terms of financial benefit, time study and employee motivation.Trakya University Scientific Research Studys Unit [27.01.2020]The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by Trakya University Scientific Research Studys Unit on 27.01.2020 with the study number 2020/18 as a high cost infrastructure study
Protective Effect of Mesna on Intestinal Ischemia-reperfusion Injury by Nitric Oxide and Arginase in an Experimental Rat Model
No full textBackground and Objective: An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that is a result of the blockage of the Superior Mesenteric Artery (SMA) because of significant clinical problems. This study aimed to evaluate the effects of the antioxidant mesna on the intestinal nitric oxide (NO) levels and arginase activity in the I/R injury at biochemical and immunohistochemical levels and to determine the tissue malondialdehyde (MDA) level as a marker of oxidative damage. Methodology: In the study, 10-12 week-old male Wistar albino rats weighing 200-250 g were used. The animals were grouped as group A-Sham-control group, group B-Intestinal I/R group and group C-mesna (n = 7). The I/R were performed by binding and opening the SMA after 120 min. In the mesna group, mesna (150 mg kg(-1), ip) was given immediately after opening the SMA. Following surgical procedures, the inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) were shown in the tissue. The levels of NO and MDA and the activity of arginase were measured. The levels of MDA and the NO, arginase activity, immunoreactivity of iNOS and eNOS were compared to the control group. Statistical analysis was done using SPSS 19 and descriptive statistics were expressed as arithmetic Mean +/- Standard deviation. Results: It was observed that the values were significantly increased (p<0.05) in the I/R group and decreased in the mesna group (p<0.05). Mesna has demonstrated its significant therapeutic effects on biochemical parameters in the I/R process by decreasing the NO level, equilibrating the iNOS and eNOS expressions and decreasing the arginase activity. Conclusion: It has been observed that mesna was helpful against the intestinal I/R injury because of its antioxidant properties considering the biochemical parameters. Mesna has demonstrated its significant therapeutic effects on biochemical parameters in the I/R process by decreasing the NO level, equilibrating the iNOS and eNOS expressions and decreasing the arginase activity.[TUBAP-2010-147]This was a part of study of research project number TUBAP-2010-147 supported Trakya University Foundation of Scientific Research
The Effect of the Quadriceps Angle on the Gait Pattern in Young Adults Aged 18-25 Years
No full textAim: The Quadriceps angle (Q angle) is used for the prediction, diagnosis, and follow-up of pathologies of knee joint. It gives information about the direction and size of forces applied to the patella. It is described as the angle formed by lines drawn from anterior superior iliac spine to the midpoint of the patella, and from the midpoint of the patella to tibial tuberosity. It gives information about the alignment of anatomical structures of the knee joint. We aimed to investigate the effects of Q angle upon gait and static balance. Materials and Methods: A sample of 106 female and 105 male healthy subjects at age 18-25 years participated in our study. After notting their height and weight, bilateral Q angles were measured with goniometer in standing and supine positions. The force platform Zebris (c) FDM System Type FDM 1.5 and the WinFDM computer program were used for the gait and stance analysis. SPSS 20 program was used for statistical analysis of the obtained data. Statistical significance limit was determined as p<0.05. Results: We assessed that there was no significant relationship between Q angle and gait analysis parameters. We observed that some of ground reaction force parameters and the butterfly diagram parameters obtained through the gait analysis as well as some of the stance analysis parameters were weak or moderately related to the Q angle. Parameters related to the Q angle did not show a pattern that would be classified by the Q angle measurement method or by the side or by the gender. Conclusion: We think that it is necessary to conduct more extensive research in order to clarify the relationship between Q angle and walking pattern. We suggest that our research will contribute to the literature as a pioneering study in terms of the relationship between the Q angle and gait analysis as well as the stance analysis
Primary dysmenorrhea and postural control: Is it a problem only during menstruation?
No full textBackground: The effects of the menstrual cycle and primary dysmenorrhea (PD) on phase-related cognitive and physical functions are controversial. This study was carried out to examine whether women with PD showed a different physical function or dual-tasking response than women without PD at times other than menstruation. Methods: Women with or without PD were recruited for the study. Individuals assessed on the first day of the menstruation and the day they reported themselves as well being (feeling good day-FGD). Zebris ? FDM Type Force Platform was used to evaluate postural stability. Individuals have were asked to perform to a 3-step balance test protocol; the first session: comfortable upright standing; the second session: standing with a motor task; the third session: standing with a cognitive task (counting backward). Correctly calculated numbers were also recorded. Results: The number of correct answers given by individuals during the cognitive dual-task was similar on the first day of menstruation and FGD (p 0,05). In the assessments performed on the first day of menstruation, there was no difference in any parameters between the groups (p 0.05). In the measurements made on FGD day with the cognitive task; there was a difference between the groups (p < 0,05). Individuals with PD had higher postural sway. Significance: This study showed that the primary dysmenorrhea is not only a problem for females during menstruation, primary dysmenorrhea causes impaired ability of the individual to perform dual-tasking and continuously affects postural stability
