5 research outputs found
Ergänzungsband zum biobibliographischen Lexikon "Nervenärzte" deutsch-russische Wissenschaftsbeziehungen im 19. Jahrhundert auf den Gebieten Psychiatrie, Neuropathologie und Neurologie
No full textBauen für die Ewigkeit Monumentalarchitektur des zwanzigsten Jahrhunderts und Städtebau in Leipzig in den fünfziger Jahren
No full textThe role of air pollution in the aetiology of type 2 diabetes
No full textBackground. The public health burden of type 2 diabetes cannot be overestimated. Prevalence of type 2 diabetes is continuously increasing and has caused a great number of deaths and economic losses. Optimal prevention measures for type 2 diabetes entail that more risk factors need to be identified. Air pollution is one of the modifiable environmental risk factors causing health problems, most notably respiratory diseases. Recently there have been indications for a spill-over of its effects into the cardio-metabolic systems. Short-term exposure to air pollution may exert acute or sub-acute inflammatory cardio-metabolic responses which on long-term, sustained exposure could lead to overt cardiovascular diseases and type 2 diabetes. However, it is unclear if long-term exposure to pollutants in the air contributes to the development of type 2 diabetes. This work generates evidence to fill knowledge gaps on the impact of air pollutants on the development of type 2 diabetes and on how different susceptibilities in the general population could contribute to the understanding of the mechanisms involved in this relationship.
Methods. First, this work summarized the existing evidence on the possible relationship between long-term exposure to air pollutants and type 2 diabetes. Furthermore, in the framework of the first follow-up of SAPALDIA- the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults, this work used indices for long-term exposure air pollution – 10-year mean particulate matter <10μm in diameter [PM10] and nitrogen dioxide [NO2] - assigned to participants’ residences using a combination of Gaussian dispersion and Land-use regression models, participants residential histories and pollutant trends at monitoring stations. It identified diabetes and metabolic syndrome cases in a comprehensive way considering self-reports, blood tests and other physical measures. It additionally identified genetic variants through genotyping on two different arrays – the Human Illumina610quad Bead Chip and the Taqman PCR assay - for 63 type 2 diabetes genetic polymorphisms [towards a diabetes gene score] and a functional polymorphism on the IL6 gene respectively. Based on the above and detailed health socio-demographic and lifestyle characteristics including smoking habits, occupational exposures, alcohol, nutrition, physical activity, body measurements and additional data collected in SAPALDIA, it was ideal to investigate the cross-sectional relationships between air pollutants and diabetes and to explore interactions [based on various susceptibilities] to understand mechanisms involved in the relationship between long-term exposure to air pollutants and type 2 diabetes.
Results. In this work, we found a positive relationship between PM2.5 and NO2 and the risk of T2D in the pooled evidence synthesized from electronic databases. In the frame of SAPALDIA biobank, we found a moderate positive association between long-term exposure to PM10 [and NO2] and prevalent diabetes, and demonstrated a sustained effect of PM10 independent of NO2, while NO2 lost its association on accounting for PM10 in multi-pollutant models. Among the measures of cardio-metabolic function, PM10 impacted most on impairment of glucose homeostasis and least on blood lipoproteins and triglycerides. The relationship between PM10 and impaired fasting glycaemia was more apparent among the physically active. Age also appeared to influence the relationship between PM10 and impaired fasting glycaemia. People at higher polygenic risk for type 2 diabetes were more susceptible to PM10. Genetic risk for insulin resistance and obesity appeared to be more relevant than those for beta-cell function in modifying the effects of PM10, especially among those with some background inflammatory conditions. Carriers of the pro-inflammatory major ‘G’ allele of IL6-572GC, with allele frequency of 93%, were also more susceptible to PM10 in relation to diabetes.
Conclusions. This work has greatly contributed to evidence suggesting the possible role of air pollutants in diabetes aetiology. The reported associations were observed at mean concentrations below current air quality guidelines. PM10 may be a good marker for aspects of air pollution [rather than NO2] relevant for the development of diabetes. In particular, PM10 might act through sub-clinical inflammation and resultant impaired insulin sensitivity. Impairment of insulin secretion may be a less relevant pathway for PM10 action. Physical activity, though beneficial, presented another likely pathway for PM10 effects. These findings, if confirmed, call for the strengthening of air quality policies and adaptation of physical activity promotion to environmental contrasts. Future studies should explore the totality of environmental exposures – exposomics –in a life-course fashion. The mediating role of DNA methylation influencing genetic expression should be further explored. For global generalizability, there is a strong need for evidence replication in developing countries where outdoor and indoor air pollution is quite high and mostly unregulated, and the burden of non-communicable diseases is rapidly growing
Nutritional aspects of sexual dimorphism in the American mink mustela vison (schreber)
No full textNutritional aspects of size-related sex differences in the diets of free-living mink were investigated in laboratory-based feeding trials with adult farm-bred mink maintained on 'natural' diets. As preliminary studies had shown that carcase utility was virtually complete, the rations presented comprised the minced whole carcasses of wild rabbit Oryctolagus cunniculus, eel Anquilla anguilla, laboratory rats and mice, and domestic fowl. Determinations of gross composition revealed significant differences between these diets; the smaller prey types, including rodents, birds and fish, were found to have a higher ratio of Apparent Digestible Energy to Nitrogen than larger items such as rabbits, although comparisons with data presented by other workers demonstrated that the variations between species within these prey groups are as great as, or greater than, those between the diets themselves. From the results of the feeding trials, it was also apparent that such diets do not differ significantly, either in digestibility or biological value and attempts to classify particular prey items in terms of their nutritional value are, therefore, of limited application in analyses of the feeding ecology of a generalist predator. Nutrient intake was related to diet composition and varied widely between trials, although the mass-specific requirements of females were higher than those of males. Comparisons of gut morphology indicated that, in females, hypertrophy of the alimentary tract may develop in response to increased energy demands. A similar adaptation was evident in both males and females from wild populations, suggesting that the natural diets of free-living mink are generally of a lower quality than the rations fed to commercially raised animals. Feeding trials were also carried out on growing kits from 56 to 105 days post partum. Sex differences in nutrient metabolism were not significant but the growth rates of males were higher than those of females. In both sexes the growth rates of kits feeding on 'natural' diets were lower than those of animals raised on commercial rations. This effect was most pronounced in males, a finding which supports the hypothesis that the degree of sexual dimorphism in this species is dependent on the extent to which the growth potential of males is constrained by dietary regime during the early phases of development
Application of mandatory rules in the private international law of contracts : a critical analysis of approaches in selected continental and common law jurisdictions, with a view to the development of South African law
No full textIncludes bibliographical referencesThis thesis is a comparative examination of the application of mandatory rules in the area of the private international law of contracts.] As will be seen during the course of this study, and as will be briefly noted in the following introductory remarks, this question arises in a number of situations. It prompts fundamental issues that have been debated for many years by academics all over the world. Some of the problems are still not fully settled
