2,783 research outputs found
Prolonged argatroban clearance in a critically ill patient with heparin-induced thrombocytopaenia
No full text10.1136/ejhpharm-2016-001136EUROPEAN JOURNAL OF HOSPITAL PHARMACY244242-24
Coagulation factors II, V, VII, IX, X and XI and mortality – a cohort study
No full text10.1016/j.rpth.2023.102193Research and Practice in Thrombosis and Haemostasis76102193
The diagnosis and treatment of venous thromboembolism in asian patients
No full text10.1186/s12959-017-0155-zTHROMBOSIS JOURNAL16
Procoagulant factors and future risk of arterial cardiovascular disease in patients with prior venous thrombosis: A cohort study.
No full text10.1002/jha2.618EJHaem413-1
Atypical lymphocyte count correlates with the severity of dengue infection
No full text10.1371/journal.pone.0215061PLOS ONE14
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No full textyapShut your yap. mouthmouthYesJ.D.A. WIDDOWSON COLLECTOR'S PERMANENT FILENot usedNot usedWithdraw
YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells
No full textPURPOSE: The YAP signaling pathway is altered and implicated as oncogenic in human mammary cancers. However, roles of YAP signaling that regulate the breast tumor angiogenesis have remained elusive. Tumor angiogenesis is coordinated by the activation of both cancer cells and vascular endothelial cells. Whether the YAP signaling pathway can regulate the intercellular interaction between cancer cells and endothelial cells is essentially unknown. METHODS: The effects of YAP on tumor angiogenesis, migration, and proliferation of vascular endothelial cells were evaluated in vitro. Expression of proteins and phosphorylating proteins involved in YAP, G13-RhoA, and PI3K/Akt signaling pathways was evaluated using the Western blotting, immunofluorescence staining, and immunohistochemistry analysis. In addition, the effects of YAP on breast cancer angiogenesis were evaluated in vivo by tumor xenograft mice. RESULTS: We showed here that conditioned media from YAP overexpressed breast cancer cells (CM-YAP+) could promote angiogenesis, accompanied by increased tube formation, migration, and proliferation of human umbilical vein endothelial cells (HUVECs). Down regulation of YAP in HUVECs reversed CM-YAP+ induced angiogenesis. CM-YAP+ time-dependently activated YAP in HUVECs by dephosphorylating YAP and increasing nuclear translocation. We also identified that both G(13)-RhoA and PI3K/Akt signaling pathway were necessary for CM-YAP+ induced activation of YAP. Besides, connective tissue growth factor (CTGF) and angiopoietin-2 (ANG-2) acted as down-stream of YAP in HUVECs to promote angiogenesis. In addition, subcutaneous tumors nude mice model demonstrated that tumors overexpressed YAP revealed more neovascularization in vivo. CONCLUSION: YAP-YAP interaction between breast cancer cells and endothelial cells could promote tumor angiogenesis, supporting that YAP is a potential marker and target for developing novel therapeutic strategies against breast cancer
Towards a Biosemiotic Model of National Literature: Samples from Singaporean Writers
No full textSingapore has four official languages and they are Malay, Chinese, Tamil, and English with respect to each ethnic group. English is the working language and the other languages are considered mother tongues of each individual ethnic group. While examining the broad social, educational, political, cultural, and economic forces that shaped the writers’ destiny in order to provide background and contexts, this dissertation is concerned with how the notion of identity is constructed and maintained in the literary works. History, myth, and fable coalesce with sharp social commentary are evident in the literature after the attainment of nationhood.
By placing the writers and their literary works in the sociological context and using the methodology proposed in this dissertation, I will present in a systematic way how individual entity or unity interacts in Singaporean literature. Firstly, it is observed that two (sometimes more than two) entities/unities from the same domain, for example, language, culture, ethnicity, and so on, are selected by the author in his literature. The entities/unities exist in the first-order and interact based on the first-order structural coupling. The “medium” is the domain in which the entity comes from in the first-order. Secondly, it is observed that interactions generally do not stop at first-order. The first-order coupling is the initial state to start off a successive reaction. The second-order structural coupling then follows, in which the triggering or interfering entity acts upon the coupled structure. This triggering or interfering entity is labeled “environment” to indicate an external force triggering an internal response of the couple. The third-order coupling is the structural coupling of the unities with its medium. In this case, the social domain is where all entities are immersed. The complex web of relationships created by the superposition of political, economic, historical, and cultural relation in the social domain are reflected in the literary works to produce a distinctive Singaporean spectrum.Abstract………………………………………………………………………….……………….1
Acknowledgements………………………………………………………………………………2
Table of Contents………………………………………………………………………………...3
Foreword…………………………………………………………………………………………7
Part One
Chapter One: Introduction
The Purpose of the Dissertation………………………………………………………….....9
Methodology………………………………………………………………………………12
A. Biological Nature of Singaporean Literature…………………………………….14
B. Semiotic Nature of Singaporean Literature………………………………………23
C. Linguistic Nature of Singaporean Literature……………………………………..29
D. Sociological Nature of Singaporean Literature…………………………………..31
Contemporary Malay Literature in Singapore……………………………………………..33
Contemporary Chinese Literature in Singapore…………………………………………...36
Contemporary Tamil Literature in Singapore……………………………………………...40
Contemporary English Literature in Singapore…………………………………………....44
Chapter Two: Biosocial System
The Multiracial and Multi-ethnical………………………………………………………...50
The Political and Institutional……………………………………………………………...56
The Transformational and Irreversible…………………………………………………….66
The National and Historical……………………………………………………………….70
The Polygonal and Variational…………………………………………………………….79
A Final Word………………………………………………………………………………83
Chapter Three: Biosocio Linguistic System
Ethnic Symbiosis: Evolution of Language in Singaporean Literature…………………….89
Emergent Voices: Up to 1970……………………………………………………………...86
New Voices: 1970-1990……………………………………………………………………93
Diverse Voices: 1990-present………………………………………………………………95
One Voice: Emergent Tongue in Singaporean Literature…………………………………..97
A Final Word……………………………………………………………………………....102
Part Two
Chapter Four: Close Readings of a Multilingual Anthology
A Biosemiotic Analysis of Rhythms: A Singaporean Millennial Anthology of Poetry……103
1. “Neighbours” by Alfian Bin Sa’at………………………………………………..104
2. “Running” by Boey Kim Cheng…………………………………………………..111
3. “What is it to Write?” (For Anna) by Felix Cheong………………………………116
4. “By the Sea at Sarimboon” by Goh Poh Seng………………………………….....123
5. “Speaking in Tongues—Singapore Style” by Goh Sin Tub……………………....126
6. “Moon Fall” by Gwee Li Sui……………………………………………………...140
7. “Cross Cultural Exchange”
(dedicated to the late Mr. Ee Tiang Hong)………………………………………..142
8. “Rain Tree” by Ho Poh Fun……………………………………………………...147
9. “Cheng Zhong Shi, First Generation” by Roger Jenkins………………………...149
10. “Island” by Koh Buck Song…………………………………………………….153
11. “The Road Taken” by Agnes Lam………………………………………………154
12. “Outlander: Hirundo Rustica” by Aaron Lee…………………………………...156
13. “You, Travelling” (for Ee Tiang Hong) by Lee Tzu Pheng……………………..159
14. “Banana Tree” by David Leo…………………………………………………...162
15. “Love is Not Enough” by Leong Liew Geok…………………………………...163
16. “A Fool’s Game” by Theodore Lim Li…………………………………………166
17. “First Vision” by Lin Hsin Hsin………………………………………………...169
18. “There is a Moment” by Alvin Pang……………………………………………171
19. “How to Fly the Singapore Flag” by Daren Shiau……………………………...173
20. “Kueh Belanda” by Desmond Sim……………………………………………...175
21. “Walking Down the Streets” by Kirpal Singh…………………………………..177
22. “我是 (I am)” by Paul Tan……………………………………………………..180
23. “Two Figures When One is Sick” by Simon Tay…………………………….....184
24. “Outing” by Edwin Thumboo…………………………………………………..185
25. “Women’s Song (1979)” (for Mum) by Angeline Yap………………………….189
26. “An Afternoon Nap” by Arthur Yap…………………………………………….190
27. “Boys in Jungle Green” by Robert Yeo………………………………………....193
28. “Before the Rain” by Yong Shu Hoong………………………………………...195
A Final Word……………………………………………………………………………...198
Chapter Five: Birth of a Legend
A Biosemiotic Analysis of the Merlion…………………………………………………...201
Close Readings of the Merlion Poems……………………………………………………205
1. “Ulysses by the Merlion” by Edwin Thumboo………………………………......205
2. “Merlion” by Liang Yue………………………………………………………….209
3. “The Merlion” by Alfian Bin Sa’at………………………………………………211
4. “Merlign” by Alvin Pang………………………………………………………....215
A Final Word………………………………………………………………………………219
Afterword
Convergence and Consolidation………………………………………………………….220
Bibliography…………………………………………………………………………………...224
Appendices
Appendix I: “By the Sea at Sarimboon” translated by Ho Chee Lick〈莎林邦海岸〉….238
Appendix II: “Merlion” by Liang Yue 梁鉞〈魚尾獅〉………………………..……….23
Intelligent agent for electronic commerce using neural network approach / Yap Hui Sun
No full textThis project is aims to developing a tool that able to collect relevant information from the World Wide Web and a tool that can be used to assists users in decision-making in the activities of e-commerce. It i been built by using the neural network of artificial intelligence approach. In more specific, the back propagation network was been used. This report contains seven chapters that uncovered the details of the project from the beginning through the end of the system evaluation and a conclusion chapter. These chapters and its contain are been arranged as the following: Chapter I - lntroduction, introducing the project various dimension, which includes the briefing of project definition, objective and scope. Chapter II - Literature Review, containing the finding on the areas related to the project, approach and algorithm used in the project and analysis of the existing system. Chapter - Methodology, justifying the method chosen for the system development, project planning that includes project schedule and system modules, procedure of the system, which are the functional and non-functional requirements,hardware and software used to develop the system. Chapter IV - System Design, describing the system now using graphic representation techniques and specifying in deep on both training and prediction module. It also describes on the database design and screen design of the system. Chapter V - System Implementation and Testing, describing the system implementation of the development environment, development of webs, Prediction Agent and ActiveX component. It also describes the testing of the system. Chapter VT - System Evaluation, presenting the evaluation of the system in term of its strengths as well as the limitations. Chapter VII - Conclusion, describing the problems encountered and solutions taken during the development of the system. Recommendations for future enhancements on the system and a conclusion that summarized of the project from the beginning of introduction through the end of system evaluation are included in this chapter
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