252 research outputs found
Expression Of Glucocorticoid Receptor Beta (GCR Β) In Asthmatic Patients And Its Correlation With Clinical Severity And Pulmonary Functions
No full textN e w Y o r k S c i e n c e J o u r n a l 2 0 1 0 ; 3 Expression Of Glucocorticoid Receptor Beta (GCR Β) In Asthmatic Patients And Its Correlation With Clinical Severity And Pulmonary Functions Engy Yousry Elsayed , Enas M Foda, khaled AH Mohammed, Hassan Shalaby, Amal Z. Abd El-Halem* and Eman Ramzy** Internal Medicine, Clinical Pathology* and Chest** Departments Faculty Of Medicine, Ain Shams University, cairo, Egypt. [email protected] ABSTRACT Background: Glucocorticoids are the gold standard treatment of bronchial asthma. Although the majority of patients with asthma respond favorably to inhaled and systemic steroid therapy, a subset of asthmatics failed to demonstrate a satisfactory response even to systemic glucocorticoid therapy. GCR β (glucocorticoid receptor beta) is a hormone binding deficit isoform of GCR (glucocorticoid receptor) which has been isolated in humans and when over expressed, it may function as a dominant negative modulator of GCR. Aim of the work: This study was designed to determine the percentage of expression of GCRβ on PBMCs: (peripheral blood mononuclear cells )of asthmatic patients and to correlate it with the clinical severity and pulmonary functions. Subjects and Methods: 60 asthmatic patients (41 males, 19 females) and 20 healthy controls were enrolled in this study. Asthmatics were classified according to GINA guidelines (2002) into mild, moderate and severe asthma. They were subdivided into asthmatic on inhaled corticosteroid (ICS) (n=35) and those not on ICS (n=25). For all studied groups, spirometeric pulmonary functions and immunohisto-chemistry staining of PBMC S were performed to analyze percentage of expression of GCRβ on PBMCs. Results: It showed that the percentage of expression of GCRβ on PBMC S were statistically higher in all asthmatic patient groups compared to control, with higher % of expression in those not on ICS. Also a statistical significant higher % of expression of GCR β in severe asthmatics compared to both mild and moderate groups was detected. In conclusion: This study highlights the importance of glucocorticoid receptor beta isoform in pathogenesis of bronchial asthma and this may be directly linked to asthma severity and can affect the response to medications especially ICS
EFFECT OF SHOULDER SIDE PACK ON DYNAMIC POSTURAL STABILITY IN YOUNG HEALTHY FEMALE
No full textBackground: Control of balance is a complex motor skill that involves integration of sensory inputs and the planning and execution of flexible movement patterns. Carrying side packs is famous in our society especially shoulder side packs. Most students carry shoulder side packs and they don't care about the way to carry them to be more balanced. The purpose of the study is to investigate the effect of carrying shoulder side pack on dynamic postural stability and to determine the best way of carrying a shoulder side pack either on the dominant side or non-dominant side that doesn’t affect dynamic postural stability in young healthy female.
Methods: Sixty female volunteers aged from 18 to 25 years old participated in the study. Biodex balance system was used to measure the dynamic postural stability in three different occasions (without carrying a shoulder side pack, with carrying a shoulder side pack on the dominant side, and on the non-dominant side) with a rest period in between.
Results: Repeated measure analysis of variance (ANOVA) followed by Bonferroni post hoc test were used to compare dynamic posture balance without carrying and during carrying a shoulder side pack on dominant and non-dominant sides. Analysis revealed that overall, anteroposterior and mediolateral stability indexes reduced significantly (P<0.0001) when carrying shoulder side pack on dominant side in comparison with when carrying shoulder side pack on non-dominant side and without carrying bag.
Conclusion: It was concluded that carrying a shoulder side pack on the non-dominant side didn't disturb the postural stability when compared to carrying on the dominant side so, we recommend the students to carry shoulder side packs on the non-dominant side
Correction: Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa
No full textThe authors of the article ‘Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa’ [1] wish to acknowledge the contribution of Professor Hussein El Fishawy. Our guidelines drew on various sources, including the Egyptian Ministry of Health guidelines, portions of which were adapted and reproduced with permission from the Egyptian Ministry of Health. Two of the authors of those guidelines, Professors Elsayed and Zaki, are also coauthors of our paper. Professor El Fishawy was the third author of the Egyptian guidelines and we would like to acknowledge his contribution to our review through this source, especially with respect to the treatment algorithms for patients with kidney transplants and those with acute kidney injury. Reference1. Elsayed HM, Wadee S, Zaki MS, Were AJO, Ashuntantang GE, Bamgboye EL, et al. Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa. Afr J Nephrol. 2020; 23(1):109-126
Représentations littéraires du sacré dans le roman maghrébin de langue française
No full textThis interdisciplinary study explores how Driss Chraïbi’s L’Homme du Livre (1995), Assia Djebar’s Loin de Médine (1991), and Anissa Boumediène’s La fin d’un monde (1991) present accounts of particular historical moments in early Islam. This study explores the role of the imagination as well as freedom of invention when reconstructing historical events. It engages the novels through a study of the interplay between the literary text and the sources and traditions that impact and shape the text narrative. Gaining direct access to the original sources in Arabic serves to analyze how religious and early historical materials are considered in and reflected by the fictional texts. Because the sources tend to differ in both content and approach, this study examines their preoccupations in order to determine the criteria of selection applied by each novelist.Ph.D.Includes bibliographical referencesIncludes vitaby Hanan Elsaye
Intrathecal Drug Delivery Systems Survey: Trends in Utilization in Pain Practice [Corrigendum]
No full textAbd-Sayed A, Fiala K, Weisbein J, et al. J Pain Res. 2022;15:1305–1314.
The authors have advised there is an error in the author list on page 1305. The author name “Alaa Abd-Sayed” should read “Alaa Abd-Elsayed”.
The authors apologize for this error
Effect of sleep related breathing disorders on ocular function
No full textAbstractIntroductionSleep disorders are common and obstructive sleep apnea hypopnea syndrome (OSAHS) is the commonest. OSAHS is not commonly diagnosed by the ophthalmologist, but it has many systemic and ocular complications.Aim of the workThe aim of this study was to detect the effect of sleep related breathing disorders on ocular function.Patients and methodsThirty patients with OSAHS were enrolled after obtaining informed consents. Patients were subjected to full history taking, Epworth sleepiness scale, anthropometric data, Mallampati score, clinical apnea score, sleep study and complete ocular examination.Results4 patients had mild OSAHS (13.33%), 12 patients had moderate OSAHS (40%) and 14 patients had severe OSAHS (46.67%) two of them had sleep hypoventilation. 4 patients were free from any ocular manifestations. In 26 patients one or more of the following ocular findings were found: floppy eyelid syndrome (FES) was detected in 3 (10%) patients, glaucoma was diagnosed in 5 (16.67%) patients, senile cataract was found in 3 (10%) patients, nonarteritic anterior ischemic optic neuropathy (NAION) was detected in 4 (13.33%) patients, papilledema was diagnosed in 3 (10%) patients and 18 (60%) patients had dry eye manifestations.In conclusionThe increased prevalence of ocular symptoms and signs in patients with OSAHS indicates a need to increase awareness and establish close collaboration with the sleep physicians with clear pathways for review of OSAHS patients by the ophthalmic services. We should study the effect of treatment of OSAHS on the ocular manifestations
Voice changes in patients with chronic obstructive pulmonary disease
No full textAbstractIntroductionVoice changes are not a direct symptom of chronic obstructive pulmonary disease (COPD), but many COPD patients experience voice changes.Aim of the workThe aim of this work was to establish the voice changes in patients with chronic obstructive pulmonary disease.Patients and methodsFifty COPD patients were conducted in this study. Patients were enrolled after obtaining informed consents. All patients were subjected to clinical diagnostic aids which include history taking (age, sex, smoking index and drug history), general and chest examinations, spirometry, arterial blood gases, chest X-ray, endoscopic examination of the larynx, auditory perceptual assessment and acoustic analysis of voice.ResultsThe age of the patients ranged from 32 to 76years, all patients were current or former smokers and the pack year index ranged from 20 to 66 with a mean±SD value of 41.16±13.80. Dysphonia was perceived in 25 (50%) patients. There was significant positive correlation between the smoking index with Jitter%, Shimmer% and the grade of dysphonia. There was significant positive correlation between Jitter%, Shimmer% and the grade of dysphonia with the large doses of ICSs usage and with pMDIs usage. Moreover, there was significant inverse correlation between Jitter%, Shimmer% and the grade of dysphonia with DPIs usage and with FVC, FEV1 and MMEF% of predicted values.In conclusionDysphonia (hoarseness) in COPD patients is multifactorial. Successful analysis should depend on cooperation between pulmonologists, voice specialists, and laryngologists
Epidemiology and clinical presentation of stroke in Upper Egypt (desert area)
No full textHamdy N El Tallawy,1 Wafaa M Farghaly,1 Reda Badry,1 Nermin A Hamdy,2 Ghaydaa A Shehata,1 Tarek A Rageh,1 Nabil A Metwally,3 Enas M Hassan,2 Sayed S Elsayed,2 Mohamed A Yehia,2 Wael T Soliman2 1Department of Neurology and Psychiatry, Assiut University, Assiut, 2Department of Neurology, El Minia University, El-Minia City, 3Department of Neurology, Al-Azhar University (Assuit Branch), Assiut, Egypt Background: Stroke is a common cause of morbidity and mortality worldwide. Four out of five strokes occur in the low- and middle-income countries. This study aims to find lifetime prevalence of stroke in Upper Egypt and to identify clinical presentations and possible risk factors of stroke in this population.Methods: This is a door-to-door (every door) study conducted on all inhabitants in Al Kharga district (representative of western desert) and Al Quseir city (representative of eastern desert). The study was conducted in two stages, and every stage consisted of three phases (screening, diagnostic, and investigatory).Results: The total lifetime prevalence of stroke was 8.5/1,000 in the population aged 20 years and more. It increased with advancing age and was higher among males than females among all age groups except in the childbearing period (20 years to <40 years of age). Lifetime prevalence of ischemic stroke (7.2/1,000) was higher than hemorrhagic stroke (1.1/1,000). Hemiparesis and hemiplegia were the commonest presentation of stroke. Headache, vomiting, and vertigo were found to be significantly more common accompaniments of hemorrhagic stroke. The most common risk factor was hypertension, followed by hyperlipidemia and diabetes mellitus.Conclusion: The total lifetime prevalence of stroke in the population aged 20 years and more in Upper Egypt (desert area) lies within the range that is recorded in developing countries. Clinical presentation and risk factors are similar to those recorded from developing and developed countries. Keywords: stroke, epidemiology, Upper Egypt, desert are
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