92 research outputs found
Spondyloarthrites et régimes d'éviction alimentaire : étude observationnelle rétrospective semi-quantitative
No full textMédecine généraleIntroduction : les patients atteints de spondyloarthrites(SpA) souffrent de symptômes gênant malgré les traitements de fond et de plus en plus se tournent vers les régimes d'éviction alimentaire pour soulager ces symptômes. Il existe peu d'études sur le sujet. Notre objectif était d'observer les effets des régimes d'éviction chez les patients atteints de SpA. Méthode : nous avons réalisé une étude semi quantitative de 18 entretiens structurés standardisés téléphoniques de patients adultes volontaires atteints de SpA réalisant un régime d'éviction alimentaire recrutés via I’ association des rhumatologues alsaciens. Résultats : 77,8% faisaient un régime sans gluten et 66,7% un régime sans produits laitiers. 55,6% avaient été conseillés par un professionnel de santé. 55,6% faisaient ce régime pour lutter contre les douleurs et 27,7% pour lutter contre les troubles digestifs. 77,8% constataient une amélioration des douleurs avec leur régime, en moyenne de 4,8+/-3,1/10 selon l'échelle numérique. L'amélioration semblait plus importante si le régime avait été conseillé par un professionnel de santé. Les patients associaient fréquemment leur régime à la pratique d'une activité physique ou à l'utilisation de médecines alternatives. Pour la majorité, la pratique du régime modifiait leur rapport à leur maladie. Conclusion : notre étude suggère un bénéfice subjectif des régimes d'éviction sur les douleurs liées à la SpA et semble apporter un bénéfice psychologique.lntroduction : Patients with spondyloarthritis (SpA) suffer from annoying symptoms despite the treatments. A lot of them try food eviction diet. There are few studies on this subject. Our goal was to observe the effects of eviction diet on patients with SpA. Method : It was a semi-quantitative study of 18 structured phone interviews of volonteer adult patients with SpA who were doing a food eviction diet. They were recruted from the association ol Alsatian rheumatologists. Results : 77,8% were doing a gluten free diet an 66,7% a dairy free diet. 55,6% were advised by a health prolessional. 55,6% were doing the diet to improve pain and 27,7% to improve gut troubles. 77,8% improved their pain with their diet, on average 4,8+/-3,1/10 on numeric scale. lt seems they improved better if the diet was suggested by a health professional. Diet was frequently associated with physical activity and alternative medecine. For the majority, doing a diet changed their relation to the disease. Conclusion : Our study suggest a subjectiv benefit of eviction diets over SpA's pains. It also seems to have a psychological benefit
Thèmes picturaux dans les appartements de marchands et artisans parisiens au XVIIIe siècle
No full textSubjects of works of Art in the homes of Parisian Tradesmen and Artisans.
This article, intended as a sociological contribution to art history, is an analysis of the artistic posessions of 750 tradesmen and 497 artisans in Paris ; it is based on inventories drawn up on their deaths, between 1725 and 1759, and deposited in the legal archives of the Seine. The author studies the respective importance of paintings and prints in the homes of both of these socioprofessional categories, as well as their division according to genre, subject, and technique. Finally, he attempts to define a common attitude to works of art among artisans and tradesmen.Chatelus Jean. Thèmes picturaux dans les appartements de marchands et artisans parisiens au XVIIIe siècle. In: Dix-huitième Siècle, n°6, 1974. Lumières et Révolution. pp. 309-324
Dosage sérique des marqueurs d'activation lymphocytaire B dans la sclérodermie systémique (étude de 150 patients)
No full textSTRASBOURG-Medecine (674822101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
High reactive oxygen species in fibrotic and non-fibrotic skin of Patients with diffuse cutaneous systemic sclerosis
No full textpeer reviewedSystemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil the pathogenic mechanisms of SSc, they are still unclear. High levels of Reactive Oxygen Species (ROS) in affected patients have been shown, and ROS are suggested to play a role in fibrosis pathogenesis. In this study we evaluate ROS levels in non-fibrotic and fibrotic skin of patients with SSc and we compare them with those obtained from healthy controls.
Patients and Methods
We enrolled 9 SSc patients fulfilling the EULAR/ACR classification criteria and 7 healthy controls. Patients included were 4 men and 5 women with mean age of 46 ±10 yrs. Controls were matched by sex and age. All patients were affected by diffuse cutaneous form of SSc and the ANA pattern anti-Scl70. Mean disease duration was 7.5±5 yrs. Skin involvement was evaluated by modified Rodnan Skin Score (mRSS). Skin samples (4 mm punch biopsy) were taken from fibrotic skin and non-fibrotic skin of patients and from healthy controls as well. To detect ROS, specimens were analyzed immediately after sampling by electron paramagnetic resonance spectroscopy. Blood samples have been drawn from all patients and controls to assess oxidative stress biomarkers.
Results
ROS levels (expressed as median and range, unit of measurement was nmol/l/min/mg of dry weight) were 24.7 (10.9– 47.0) in fibrotic skin, 18.7 (7.3–34.0) in non-fibrotic skin and 7.7 (3.5–13.6) in healthy controls skin. ROS levels in Fibrotic and Non-fibrotic skin of SSc patients were significantly higher than in Healthy Controls (p=0.002 and p=0.009, respectively). ROS levels in fibrotic skin were raised in comparison to non-fibrotic skin, when samples related to each patient were compared (p=0.01). ROS levels in fibrotic skin were correlated with forced vital capacity (r= -0.75, p=0.02) and erythrocyte sedimentation rate (r=0.70, p=0.04). All other clinical and lab parameters showed no significant correlation. When compared to controls, blood from SSc patients showed lower ascorbate (vitamin C) levels (8 [3.8-9.8] vs. 10.5 [9-19.1] mg/L, p=0.004) and higher lipid peroxides (873.5 [342-1973] vs. 422 [105-576] μmol/L, p=0.004).
Conclusion
Our results indicate the presence of high oxidative stress both in non-fibrotic skin and fibrotic skin of SSc patients, but with higher tendency in the latter. Raised ROS levels in non-fibrotic skin of SSc patients might be a hint of early involvement in skin fibrogenesis. However, a longitudinal prospective study is necessary for such proof
Apport de l’écho-doppler pour le diagnostic d’artérite à cellules géantes
No full textInternational audienceUltrasound is a useful imaging modality for the diagnosis of giant cell arteritis. Ultrasound of temporal arteries is recommended as the first imaging modality in patients with suspected predominantly cranial giant cell arteritis. The thickening of the arterial wall (halo sign) is the ultrasound finding most suggestive of giant cell arteritis. In patients in whom there is a high clinical suspicion of giant cell arteritis and a halo sign, the diagnosis of giant cell arteritis may be made without temporal artery biopsy
Malignancies in patients with Anti-RNA polymerase iii antibodies and systemic sclerosis: analysis of the EULAR scleroderma trials and research cohort and possible recommendations for screening
No full textOBJECTIVE: To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients.
METHODS: (1) Analysis of the EUSTAR database: 4986 patients with information on their anti-RNAP3 status were included. (2) Case-control study: additional retrospective data, including malignancy history, were queried in 13 participating EUSTAR centers; 158 anti-RNAP3+ cases were compared with 199 local anti-RNAP3- controls, matched for sex, cutaneous subset, disease duration, and age at SSc onset. (3) A Delphi exercise was performed by 82 experts to reach consensus for cancer screening in anti-RNAP3+ patients.
RESULTS: In the EUSTAR registry, anti-RNAP3 were associated in multivariable analysis with renal crisis and diffuse cutaneous involvement. In the case-control study, anti-RNAP3 were associated with gastric antral vascular ectasia, rapid progression of skin involvement, and malignancies concomitant to SSc onset (OR 7.38, 95% CI 1.61-33.8). When compared with other anti-RNAP3+ patients, those with concomitant malignancies had older age (p < 0.001) and more frequent diffuse cutaneous involvement (p = 0.008). The Delphi exercise highlighted the need for malignancy screening at the time of diagnosis for anti-RNAP3+ patients and tight followup in the following years.
CONCLUSION: Anti-RNAP3+ patients with SSc have a high risk of concomitant malignancy. These results have implications for clinical practice and suggest regular screening for cancer in anti-RNAP3+ patients
Comment faire le diagnostic et mieux comprendre les myopathies inflammatoires ? L’utilité des auto-anticorps
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