1,721,078 research outputs found
Pathophysiology roles and translational opportunities of miRNAs in cutaneous melanoma
No full textMelanoma is a malignancy of melanocytes, pigment-producing cells that are predominantly located in the skin. Melanoma accounts for 3%-5% of all cutaneous cancers but determines approximately 75% of all skin cancer deaths. Cutaneous melanoma (CM) affects principally fair-skinned populations, with variable incidence attributable to latitude and differences in sun exposure. The geriatric population is principally affected by this tumor and the median age at diagnosis is 65 years, but this neoplasm is also frequently diagnosed in adolescent and young adult populations. Melanoma incidence increases linearly starting from the age of 25 years until 50. Melanoma affects women and men indifferently, but men are generally more affected. The incidence rates in the world are 3.5% for men and 2.9% for women. When age is considered, adolescent and young adult women are more susceptible to melanoma than men. However, after the age of 40, the rates reverse, and melanoma incidence among men is greater than in women
Potential of curcumin in skin disorders
Full text linkCurcumin is a compound isolated from turmeric, a plant known for its medicinal use. Recently, there is a growing interest in the medical community in identifying novel, low-cost, safe molecules that may be used in the treatment of inflammatory and neoplastic diseases. An increasing amount of evidence suggests that curcumin may represent an effective agent in the treatment of several skin conditions. We examined the most relevant in vitro and in vivo studies published to date regarding the use of curcumin in inflammatory, neoplastic, and infectious skin diseases, providing information on its bioavailability and safety profile. Moreover, we performed a computational analysis about curcumin’s interaction towards the major enzymatic targets identified in the literature. Our results suggest that curcumin may represent a low-cost, well-tolerated, effective agent in the treatment of skin diseases. However, bypass of limitations of its in vivo use (low oral bioavailability, metabolism) is essential in order to conduct larger clinical trials that could confirm these observations. The possible use of curcumin in combination with traditional drugs and the formulations of novel delivery systems represent a very promising field for future applicative research
Cutaneous Melanoma with "Paradoxical" p16 Hyper-expression: Molecular and Immunohistochemical Analysis of an Exceedingly Rare Entity with a Focus on Regulator Molecules of the Cell Cycle
No full textNTRK fusions in pigmented spindle cell nevus/Reed nevus: an immunohistochemical study on a large multicentric Italian cohort
No full textNo abstract availabl
NAIL APPARATUS MELANOMA: DERMOSCOPIC AND HISTOPATHOLOGIC CORRELATIONS ON A SERIES OF 23 PATIENTS FROM A SINGLE CENTER.
No full textBackground Nail apparatus melanoma (NAM) is an uncommon tumour, and there are few studies focused on its der-
moscopic features.
Objective The aims of our study were to evaluate the diagnostic accuracy of dermoscopy in NAM. A diagnostic algo-
rithm for adult patients with suspected NAM is proposed.
Methods We collected NAM dermoscopic images of patients with a proven histopathology from 2008 until 2015. Clini-
cal and dermoscopic images were blindly examined by two dermatologists, and correlations between histopathological
aspects and dermoscopic features were investigated.
Results We retrospectively collected NAM dermoscopic images associated with a proven histopathology of 23 Cau-
casian patients. Only cases with available both preoperative dermoscopic images and bioptic specimens were included.
Seventeen women and six men were included. The mean age at diagnosis was 63 years (range 18–92).
Conclusion We created an algorithm to indicate the correct way to follow an adult patient with suspected NAM. This
algorithm may ameliorate management in case of suspected NAM and possibly facilitate an early diagnosi
Visual Dermatology: Self-induced chronic Saxophone penis due to paraffin injections.
No full textnot presen
USCAP 2022 Abstracts: Dermatopathology (292-340) Hematoxylin and Eosin (H&E) is Preferable to Double Staining (CD34/SOX10) for the Detection of Lymphovascular Invasion in Cutaneous Melanoma
No full textNo abstract availabl
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