2,099 research outputs found
R.C. Farrell Store
No full textPhotograph - People standing in front of R.C. Farrell, General Merchant store, Athabasca, Alberta. Left to right: Lance Smith, Louis Menard, Romeo Farrell, Athela LaRue Farrell, and Ray Vari
A tournament of linkage tests in complex inheritance
No full textThe performance of some weakly parametric linkage tests in common use was compared on 200 replicates of oligogenic inheritance from Genetic Analysis Workshop 10. Each random sample for the quantitative trait was dichotomized at different thresholds and also selected through 2 affected sibs, generating 8 combinations of sample and variable. The variance component program SOLAR performed best with a continuous trait, even in selected samples, when the population mean was used. The sib-pair program SIBPAL2 was best in most other cases when the phenotype product, population mean, and empirical estimates of pair correlations were used. The BETA program that introduced phenotype products was slightly more powerful than maximum likelihood scores under the null hypothesis and approached but did not exceed SIBPAL2 under its optimal conditions. Type I errors generally exceeded expectations from a chi2 test, but were conservative with respect to bounds on lods. All methods can be improved by use of the population mean, empirical correlations, logistic representation for affection status, and correct lods for samples that favour the null hypothesis. It remains uncertain whether all information can be extracted by weakly parametric methods and whether correction for ascertainment bias demands a strongly parametric model. Performance on a standard set of simulated data is indispensable for recognising optimal methods
A Review of: Biobloc Therapy, by John R.C. Mew
No full textThis text, written and published by its British author, John R.C. Mew, details an integrated orthodontic and orofacial myofunctional treatment approach entitled Biobloc Therapy [...
Experimental Research and Numerical Analysis on the Law of Deteriorated Performance for R.C. Frame Structure with Seismic Damages under Elevated Temperature (part II)
No full textThe cracks were pre-settled to the R.C. frame structure caused by earthquake which was defined as the damage index ω during the modeling process with analysis software-ANASYS. The temperature field contour curve were calculated for the column and beam, the law of deteriorated bearing capacity with time for the R.C. frame structure under elevated temperature were brought forward，which can adapt to R.C. frame structure with different damage index ω caused by earthquake.The relationship between ω and deteriorated bearing capacity for R.C. frame structure was also given, which was proved to be effective and correct according to comparison with the data recorded from the elevated temperature experiment designed by author.</jats:p
Internal Friction in The Region of The Grain Boundary Peaks in Pure Zirconium and Dilute Zirconium Alloys
No full textTitle: Internal Friction in The Region of The Grain Boundary Peaks in Pure Zirconium and Dilute Zirconium Alloys, Author: R.C. Robinson, Location: ThodeInternal friction, in the region of the
grain boundary peaks, has been examined in nominally
pure zirconium and dilute zirconium alloys. Experimental
observations were made using both torsion and
reed internal friction pendulums. The effect of various
heat treatments on the peaks were investigated. Strain
amplitude dependent damping in the region of the Low
Temperature Peak was observed. A qualitative model
is presented to explain the experimental observations.ThesisMaster of Engineering (ME
De Fast-Fourier Transform: Het gebruik van de routine van R.C. Singleton
No full textDoel van dit rapport is de lezer inzicht te verschaffen in het gebruik van de FFT-routine van R.C. Singleton zoals die in het rekencentrum van de T.H. - Delft in gebruik is. Voor een beschrijving van de werking van deze routine wordt verwezen naar het in de literatuurlijst vermelde artikel van Singleton (Lit. 1). Met nadruk wordt erop gewezen dat er meerdere FFT-routines in omloop zijn die alle anders werken en daarom in gebruik kunnen verschillen. Het onderhavige rapport beschrijft uitsluitend het gebruik van de routine van Singleton. Als laatste punt in deze inleiding wordt speciaal het boek van Brigham genoemd (Lit. 2) waarin zeer veel informatie te vinden is over het gebruik van de FFT-methodeHydraulic EngineeringCivil Engineering and Geoscience
The Challenge of Reversing Theories to Hybridize Structures with Fiber Metal Laminate Design Concepts
No full textTo further optimize aeronautical structures, an increased level of material hybridization is required. Optimization efforts aim to identify optimal design solutions that satisfy prescribed requirements. However, this demands reversal of currently available knowledge on hybrid structural technologies, which are often formulated as theories predicting performance based on known load cases and selected material configurations. After briefly reviewing the available fundamental theories for strength, fatigue, and damage tolerance of hybrid structures, this paper discusses the challenges in reversing these theories. Solutions are proposed in which theories can be approximated to significantly reduce the computational time while maintaining the required level of accuracy.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Structural Integrity & Composite
Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region.
No full textAsthma is a common, complex human disease. Gene discovery in asthma has been complicated by substantial etiological heterogeneity, the possibility of genes of small effect and the concomitant requirement for large sample sizes. Linkage to asthma phenotypes has been investigated most intensively in the 5q chromosomal region, although results have been inconsistent across studies and all studies have had modest sample sizes. One potential solution to these issues is to combine data from multiple studies in a retrospective meta-analysis by pooling either summary statistics or raw data. The International Consortium on Asthma Genetics combined data from 11 data sets (n = 6277 subjects) to investigate evidence for linkage of 35 markers spanning the cytokine cluster on chromosome 5q31–33 to 'asthma' dichotomy and total serum immunoglobulin E (IgE) levels. Chromosome 5q markers typed in different centers were integrated into a consensus map to facilitate effective data pooling. Multipoint linkage analyses using a new Haseman–Elston method were performed with all data sets pooled together, and also separately with the resulting linkage statistics pooled by meta-analytic methods. Our results did not provide any evidence significant at the 5% level that loci conferring susceptibility to asthma or atopy are present in the 5q31–33 region; however, there was some weak evidence (empirical P = 0.077) of linkage to asthma affection. This study suggests that loci in 5q31–33 have at most a modest effect on susceptibility to asthma or total serum IgE levels, may not be detectable or present in all human populations and are difficult to detect even using combined linkage evidence from 2400–2600 full sibling pairs
Regression‐based Multivariate Linkage Analysis with an Application to Blood Pressure and Body Mass Index
No full textStrength and ductility of R.C. columns strengthened with steel angles and battens
No full textIn this paper the behaviour of R.C. members externally strengthened with steel angles and battens subjected to axial force and bending moment is analysed. A fibre model was utilised to predict the moment–curvature diagrams of the strengthened members on the basis of stress–strain curves of the constituent materials (confined concrete, steel bars and angles) recently derived by the author. The stress–strain curves utilised for compressed concrete were able to take into account the confinement effects induced by longitudinal (bars and steel angles) and transverse (stirrups and battens) steel reinforcements. Constitutive laws in compression for confined concrete and steel bars and angles were utilised for a preliminary calibration of the compressive response of axially loaded columns strengthened with steel cages. Therefore axial force and bending moment diagrams and moment curvature diagrams were derived and verified against experimental data available in the literature. Finally, a parametric analysis showing the influence of the main parameters governing the problems (angle and strip geometry and mechanical properties of constituent material) was carried out, mainly referring to moment axial force domains, moment curvature diagrams. The analysis showed the effectiveness of this reinforcing technique in improving both the strength and the ductility of R.C. columns
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