108 research outputs found
sj-docx-1-jcn-10.1177_08830738221078683 - Supplemental material for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts
No full textSupplemental material, sj-docx-1-jcn-10.1177_08830738221078683 for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts by Abdelrahim A. Sadek, Mohammed A. Aladawy, Tarek M. M. Mansour, Mohamed F. Ibrahim, Montaser M. Mohamed, Eman F. Gad, Amr A. Othman, Hosny A. Ahmed, Abdin K. Kasim, Wael M. Wagdy, Mohamed H. T. Hasan and Elsayed Abdelkreem in Journal of Child Neurology</p
sj-docx-2-jcn-10.1177_08830738221078683 - Supplemental material for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts
No full textSupplemental material, sj-docx-2-jcn-10.1177_08830738221078683 for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts by Abdelrahim A. Sadek, Mohammed A. Aladawy, Tarek M. M. Mansour, Mohamed F. Ibrahim, Montaser M. Mohamed, Eman F. Gad, Amr A. Othman, Hosny A. Ahmed, Abdin K. Kasim, Wael M. Wagdy, Mohamed H. T. Hasan and Elsayed Abdelkreem in Journal of Child Neurology</p
Evaluation of anti-thyroglobulin antibodies and thyroid stimulating hormone level in cases of recurrent early pregnancy loss
No full textBackground: Autoimmune thyroid disease (AITD) is by far the most frequent cause of hypothyroidism in women in reproductive age. The prevalence of hypothyroidism in the general population of reproductive age is 2-3%. The objective of this study was to evaluate maternal anti-thyroglobulin (ATG) concentrations and thyroid stimulating hormone (TSH) level in cases of recurrent miscarriage.Methods: 200 female patients divided into two groups. Group A: 100 female patients with history of recurrent miscarriage. Group B: 100 female patients with at least 2 living children and without history of recurrent early miscarriage. Antithyroglobulin antibodies using chemilumeniscence immunoassay (normal level up to 115 IU/ml) and TSH level using chemilumeniscence immunoassay (normal level 0.350-2 U/ml) were assessed.Results: 8.0% of cases (n = 100) and 2.0% of control group (n = 100) were positive for anti TG antibodies. There was no significant relationship between the presence of anti TG antibodies and RPL (p = 0.052). 19% of cases (n = 100) were positive for TSH level. On the other hand, 14% of control group (n = 100) were positive for TSH level there was no significant relation between recurrent pregnancy loss and TSH, (P = 0.34).Conclusions: Neither TSH nor ATG showed significant difference in cases with recurrent miscarriage
Mitochondrial DNA Copy Number Variation as a Potential Predictor of Renal Cell Carcinoma
No full textBackground Peripheral blood mitochondrial DNA (mtDNA) copy number alteration has been suggested as a risk factor for several types of cancer. The aim of the present study was to assess the role of peripheral blood mtDNA copy number variation as a noninvasive biomarker in the prediction and early detection of renal cell carcinoma (RCC) in a cohort of Egyptian patients. Methods Quantitative real-time polymerase chain reaction (qPCR) was used to measure peripheral blood mtDNA copy numbers in 57 patients with newly diagnosed, early-stage localized RCC and 60 age- and sex-matched healthy individuals as a control group. Results Median mtDNA copy number was significantly higher in RCC cases than in controls (166 vs. 91, p<0.001). Increased mtDNA copy number was associated with an 18-fold increased risk of RCC (95% confidence interval: 5.065-63.9). On receiver operating characteristic curve analysis, it was found that mtDNA could distinguish between RCC patients and healthy controls, with 86% sensitivity, 80% specificity, 80.3% positive predictive value and 85.7% negative predictive value at a cutoff value of 108.5. Conclusions Our results showed that increased peripheral blood mtDNA copy number was associated with increased risk of RCC. Therefore, RCC might be considered as part of a range of potential tumors in cases with elevated blood mtDNA copy number. </jats:sec
Assessing risk and profitability of Islamic banks: a comparison between Islamic and conventional banks in the Gulf Cooperation Council
No full textThis is a study on assessing the risk and profitability associated with Islamic bank investments and operations in the Gulf Cooperation Council (GCC) countries for three years from 2009 to 2011. It is mainly focused on measuring risk and profitability by looking at stock returns, bond ratings and financial institution ratios. Stock returns of Islamic banks were analyzed and compared to stock returns of commercial banks in five countries. Credit ratings for all Islamic banks with issued bonds were compared to those of conventional banks. In addition, banking industry financial ratios were used to analyze the operations of two types of banks, with the sample including all listed banks. The study revealed that Islamic banks have higher average stock returns and slightly higher standard deviations, reflecting high returns and risks compared to conventional banks. After scaling ratings into numbers, the credit ratings were found to favor conventional banks, with an average rating of A- for long term investments and A-2 for short term investments. With regards to financial ratios, the t-test and F-test results showed that there were significant differences between the means of the two bank types. Return on equity, return on assets and deposit to equity ratios were in favor of conventional banks. Islamic banks had a higher equity to asset ratio, loan to deposit ratio and interest margin to earning assets. Finally, ' there is no significant difference between the two bank types' means with regards to coverage ratio, earning assets to asset ratio and market return on equity. --Leaf 1.The original print copy of this thesis may be available here: http://wizard.unbc.ca/record=b189128
Toxoplasma gondii Suppresses Th2-Induced by Trichinella spiralis Infection and Downregulates Serine Protease Genes Expression: A Critical Role in Vaccine Development
No full textBackground: Toxoplasma gondii coinfection can modify host immune responses and the severity and spread of other parasites. We investigated how T. gondii and Trichinella spiralis infections counter-regulate each other's immune responses.
Methods: The parasite burden, the expression of T. gondii rhoptry kinase ROP18 and T. spiralis putative serine protease (TsSP), the IgG1 and IgG2a responses, besides histopathological and immunohistochemical staining with iNOS and arginase were used to evaluate the dynamics of coinfection.
Results: Through their effects on host immune responsiveness, coinfection with T. gondii modified the virulence of T. spiralis infection. Coinfected animals with high and low doses of T. gondii demonstrated significant reductions in the T. spiralis burden of 75.2% and 68.2%, respectively. TsSP expression was downregulated in both groups by 96.2% and 86.7%, whereasROP18 expression was downregulated by only 6% and10.6%, respectively. In coinfected mice, elevated levels of T. gondii-specific IgG2a antibodies were detected. Th1 induced by T. gondii inhibits the Th2 response to T. spiralis in coinfected animals with high iNOS expression andlow-arginine1 expression.
Conclusion: T. gondii infection induces a shift toward a Th1-type immune response while suppressing a helminth-specific Th2 immune response, paving the way for developing novel vaccines and more efficient control strategies
Orthodontic treatment need of Saudi Arabian children
No full textPLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact [email protected] (D.Sc.D.)--Boston University. Henry M. Goldman School of Dental Medicine, 1997 (Dental Public Health).Includes bibliographic references (leaves 83-87).The purpose of this study was to determine the prevalence of malocclusion in Saudi Arabian children, and hence to determine their orthodontic treatment need. The Index of Orthodontic Treatment Need (IOTN) which was developed by Brook and Shaw in 1989 (7), was modified and used accordingly for this study. The IOTN contains two components; the Dental Health Component (DHC) and the Aesthetic Component (AC). Each component grades an individual accordingly to his/her orthodontic treatment need. The modifications (Modified DHC) that were made in this study to the IOTN included the addition of the following: Spacing, midline deviations, functional jaw limitations, bimaxillary protrusions, tooth displacements without space deficiency, facial asymmetries and future surgery. Seventy-five Saudi schoolchildren, aged 10-14 years old were examined. According to the findings of the study, a statistically significant difference between the original DHC and the Modified DHC was found (t-test = 4.161, df=74, p=0.000). When the original DHC was used, the majority of students were in a lower grade level. When the Modified DHC was used, 20.0% of the students moved to a higher grade level, indicating more treatment need. Approximately, 42% of the males and 48% of the females were in grade leve1 4, indicating great need for Orthodontic treatment. The Modified IOTN was also used to determine the most prevalent malocclusal feature present, and according to the results, overbite was determined to be the predominant feature in both males and females (30.3% and 28.6% respectively). This was followed by crowding and functional jaw limitations in both sexes (21.2% & 18.2% in males, 23.8% & 11.9% in females respectively). Explanations of why overbite was the most predominant feature is provided.
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Plasma long non-coding RNA <i>HOTAIR</i> as a potential biomarker for gastric cancer
No full textBackground: Long non-coding RNAs (lncRNAs) Hox transcript antisense intergenic RNA ( HOTAIR) has been suggested to be implicated in gastric cancer tumorigenesis and progression; however, little is known about the role of the plasma HOTAIR in gastric cancer diagnosis and prognosis. Objective: The current study was aimed at investigating the clinical relevance of plasma long non-coding HOTAIR as a non-invasive diagnostic biomarker in gastric cancer. Methods: Plasma HOTAIR expression was measured in 50 patients with newly diagnosed gastric cancer and 50 age- and sex-matched healthy controls using quantitative reverse transcription polymerase chain reaction. Results: Plasma level of HOTAIR was significantly higher in gastric cancer patients compared with healthy controls ( P < 0.001). By using receiver operating characteristic curve analysis, it was found that plasma HOTAIR could diagnose gastric cancer with 88% sensitivity and 84% specificity. Furthermore, increased HOTAIR expression was associated with advanced tumor stages, higher grades, and metastasis. Conclusion: Plasma HOTAIR might serve as a potential non-invasive biomarker for diagnosis of gastric cancer. </jats:sec
An optimized dose of raspberry ketones controls hyperlipidemia and insulin resistance in male obese rats: Effect on adipose tissue expression of adipocytokines and Aquaporin 7
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