121 research outputs found
Expression Of Glucocorticoid Receptor Beta (GCR Β) In Asthmatic Patients And Its Correlation With Clinical Severity And Pulmonary Functions
No full textN e w Y o r k S c i e n c e J o u r n a l 2 0 1 0 ; 3 Expression Of Glucocorticoid Receptor Beta (GCR Β) In Asthmatic Patients And Its Correlation With Clinical Severity And Pulmonary Functions Engy Yousry Elsayed , Enas M Foda, khaled AH Mohammed, Hassan Shalaby, Amal Z. Abd El-Halem* and Eman Ramzy** Internal Medicine, Clinical Pathology* and Chest** Departments Faculty Of Medicine, Ain Shams University, cairo, Egypt. [email protected] ABSTRACT Background: Glucocorticoids are the gold standard treatment of bronchial asthma. Although the majority of patients with asthma respond favorably to inhaled and systemic steroid therapy, a subset of asthmatics failed to demonstrate a satisfactory response even to systemic glucocorticoid therapy. GCR β (glucocorticoid receptor beta) is a hormone binding deficit isoform of GCR (glucocorticoid receptor) which has been isolated in humans and when over expressed, it may function as a dominant negative modulator of GCR. Aim of the work: This study was designed to determine the percentage of expression of GCRβ on PBMCs: (peripheral blood mononuclear cells )of asthmatic patients and to correlate it with the clinical severity and pulmonary functions. Subjects and Methods: 60 asthmatic patients (41 males, 19 females) and 20 healthy controls were enrolled in this study. Asthmatics were classified according to GINA guidelines (2002) into mild, moderate and severe asthma. They were subdivided into asthmatic on inhaled corticosteroid (ICS) (n=35) and those not on ICS (n=25). For all studied groups, spirometeric pulmonary functions and immunohisto-chemistry staining of PBMC S were performed to analyze percentage of expression of GCRβ on PBMCs. Results: It showed that the percentage of expression of GCRβ on PBMC S were statistically higher in all asthmatic patient groups compared to control, with higher % of expression in those not on ICS. Also a statistical significant higher % of expression of GCR β in severe asthmatics compared to both mild and moderate groups was detected. In conclusion: This study highlights the importance of glucocorticoid receptor beta isoform in pathogenesis of bronchial asthma and this may be directly linked to asthma severity and can affect the response to medications especially ICS
Effect of antenatal education on pregnant women`s knowledge, attitude and preferences of delivery mode
No full textAbstract Background Childbirth is considered as the happiest action that occurs in any parent's life. Although childbirth is a natural process, the choice of delivery mode is one of the concerns of pregnant women. Consequently, the objective of this study to assess the effect of antenatal education on pregnant women`s knowledge, attitude, and preferences of delivery mode. Methods A quasi-experimental research design was utilized to achieve the study utilizing 140 purposive sample of pregnant women selected from antenatal outpatient clinics at the New Obstetrics and Gynecology Hospital in Mansoura, Egypt. Results The study findings reported that there was a significant improvement in total scores of the intervention group`s knowledge and attitude toward the modes of delivery, with a highly statistically significant difference (p < 0.001) at post-intervention compared to the control group. Conclusion Prenatal education sessions were linked to a significantly improved maternal outcome in terms of knowledge, attitude, and preferences for delivery mode (p < 0.001). Trial registration ClinicalTrials.gov, NCT06561984, registered on August 19, 2024, retrospectively registered
Continuous-Flow Organic Transformations Using Resin- and Silicon-Supported Catalysts
No full text学位記番号 : 博理工甲第1377号博士の専攻分野の名称 : 博士(理学)
学位授与年月日 : 令和7年9月19日textapplication/pd
Numerical investigation of MIL-101(Cr)/GrO composite performance in adsorption cooling systems
No full textMIL-101(Cr)/graphene oxide composites were investigated for the application of adsorption cooling. Two composites with two different synthesis techniques were chosen, 2%GrO-syn and 5%GrO-phys, owing to the superior water adsorption uptake of the first and the high thermal conductivity of the latter. The thermodynamic cycle performance of a two-bed adsorption system was evaluated using Simulink software to assess the performance of each composite. Under the operating conditions investigated, the 2%GrO-synthesis composite showed a similar specific cooling power (SCP) and coefficient of performance (COP) to the MIL-101(Cr) system with no change in cycle time and with a lower desorption temperature of 90°C. The 5%GrO-phys composite showed a decreased SCP and an increased COP at the same cycle time. Nevertheless, the desorption temperature of such system decreased from 100°C for the neat material to only 80°C. This highlights the potential of such composites in more efficient adsorption heat pump systems.</p
Serum metabolomics-driven network pharmacology elucidate the anti-rheumatoid arthritis potential of garden cress
No full textAbstract Garden cress (Lepidium sativum L.) has been traditionally utilized for the treatment of various diseases and is increasingly consumed as a functional food and alternative medicine in many countries due to its therapeutic potential. Notably, L. sativum is a promising candidate for mitigating rheumatoid arthritis (RA). This study employed a serum pharmacochemistry approach combined with a network pharmacology strategy to identify the active components and elucidate the underlying mechanisms of L. sativum in RA management. An RA rat model was established using Complete Freund’s Adjuvant (CFA). Following L. sativum administration, bioactive serum components were identified and quantified as markers of its pharmacological activity. Twenty-six serum metabolites, including 11 prototype compounds and 15 derived metabolites, were identified as key bioactive constituents absorbed at significant concentrations, potentially mediating the anti-RA effects of L. sativum. Among these, fatty acids and their conjugated metabolites emerged as the most relevant. Through network pharmacology, potential target genes and associated pathways were predicted. KEGG pathway analysis highlighted critical RA-related pathways, including arachidonic acid metabolism, modulation of inflammatory regulators in TRP channels, linoleic acid metabolism, and antifolate resistance pathways. Experimental data demonstrated that L. sativum significantly downregulated key inflammatory mediators such as IL-1β, TNF-α, MMP-9, CYP1A2, PLA2G2A, and MAPK8. This integrated study provides insight into the molecular mechanisms and active constituents of L. sativum, serving as a foundational reference for its therapeutic application against RA
The Potential Effects of Kinetin Implementation on Hybrid Rice Seed Production under Water Deficit
No full textDrought is one of the main abiotic stresses responsible for reducing crop yields worldwide. In hybrid rice production, cytoplasmic male sterility (CMS) displays an alternative plan for producing high-yielding hybrid rice depending on the hybrid vigor. Kinetin (Kin) has an essential role during the early phase of grain setting by regulating cell division, assimilate flow, and osmotic modification under water deficit. Growth, floral, and yield-related traits were evaluated in two CMS lines under five irrigation intervals and two concentrations of the phytohormone kinetin. Our study was conducted to explore the effects of irrigation intervals (continuous flooding (CF), irrigation every six (I6), nine (I9), twelve (I12), and fifteen (I15) days, and kinetin exogenously applied (control, 15 mg L−1, and 30 mg L−1) on growth, floral, and yield-related traits. Growth traits (i.e., number of leaves (NOL), days to complete leaf number (DCLN), days to heading (DTH, 50%), flag leaf area (FLA), and plant height (PH)), floral traits (i.e., duration of spikelet opening (DSO), panicle length (PL), spikelet opening angle (SOA), and panicle exertion (PE)), and seed yield traits (i.e., seed set (SS), panicle weight (PW), seed yield (SY), harvest index (HI), and number of fertile panicles per hill (NFP)) in two CMS lines. Implementation of kinetin displayed the highest significant and positive values for all growth, floral, and yield-related traits when compared to the control (average of applied irrigation intervals). Applying 30 mg L−1 kinetin positively enhanced the growth traits (i.e., NOL, FLA, and PH with 4.1%, 5%, and 3%, respectively), floral traits (i.e., PL, PE, SOA, and DSO with 5.4, 5.7, 5.9, and 5.4%, respectively), and yield-related traits (i.e., PW, SS, SY, HI, and NFP with 22%, 17%, 14%, 14.5%, and 15%, with the same sequence) compared to non-treated plants. Consequently, exogenous foliar spray of kinetin could be an effective process in minimizing the harmful effects (the reduction in PW, SS, SY, HI, and NFP recorded 41%, 61%, 45%, 30%, and 48%, respectively, under I15 conditions when compared to CF) of water deficit in hybrid rice and increasing seed production
Assessment of the effect of percutaneous coronary intervention on left ventricular function in patients with coronary artery disease using tissue doppler strain rate imaging
No full textObjectives: this study aimed to assess the effects of percutaneous coronary intervention (PCI) on regional and global left ventricular (LV) functions (systolic and diastolic) in patients with coronary artery disease (CAD) using tissue Doppler strain rate (SR) imaging. Patients and Methods: in this study, we randomly assigned 100 Egyptian adult symptomatic patients with CAD that underwent coronary angiography and candidate for PCI on the left anterior descending artery. LV early diastolic and systolic SR were measured 24 h before and 48 h after PCI. Results: Most of the LV diastolic and systolic parameters (A, E', E/A, E/E', and isovolumic relaxation time [IVRT]) showed significant difference before and after elective PCI, while mitral E velocity, DT, and pulmonary vein flow before and after PCI did not show significant difference. SR imaging findings showed high significant difference mean peak systolic and mean early diastolic SR of ischemic regions after PCI; mean early diastolic SR before PCI was 1.86 ± 0.13 while after PCI was 2.57 ± 0.18 (P < 0.001) and mean peak systolic SR before PCI was 0.65 ± 0.18 while after PCI was 0.901 ± 0.15 (P < 0.001). Conclusion: Most of the LV diastolic and systolic parameters (A, E', E/A, E/E', and IVRT) improved after PCI in CAD patients. Furthermore, regional myocardial function as measured by mean peak systolic and mean early diastolic SR in the ischemic segments improved significantly compared with that in nonischemic segments
Characteristics of Ankylosing Spondylitis patients living in Qatar
No full textAbstractAim of the workTo study the clinical, laboratory and radiographic characteristics of ankylosing spondylitis (AS) patients living in Qatar.Patients and methodsSixty-two consecutive AS patients including 4 Qataris were enrolled. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and AS quality of life (ASQoL) scores were calculated. Inflammatory markers, human leukocytic antigen-B27 (HLA-B27), plain x-rays and magnetic resonance imaging of the sacroiliac joint and spine were considered.ResultsMean age at symptom onset was 25.9±7.3years and at diagnosis 32.3±8.4years with an average delay in the diagnosis of 6.4years. The male-to-female ratio was 5.2:1. Arabs comprised 40.3% while 59.7% were non-Arabs. HLA-B27 was positive in 80.7%. Family history of spondyloarthritis was present in 16 (25.8%) patients. All patients had inflammatory low back pain. Peripheral arthritis was observed in 46.8%, heel enthesitis in 37.1% and tenosynovitis in 14.5% patients. Anterior uveitis occurred in 14.5% patients. Radiological evidence of bilateral sacroiliitis and spine involvement was observed in 83.3% and 59.7% patients respectively. Mean erythrocyte sedimentation rate and C-reactive protein were 20.3±14.2mm/hr and 11.4±11.8mg/L respectively. Mean BASDAI, BASFI and ASQoL were 3.3±1.8, 2.9±2.1 and 6.5±5.2 respectively. Twenty-eight patients (45.2%) were maintained on NSAIDs monotherapy, 14.5% were receiving DMARDs and 40.3% were on biologics.ConclusionThe characteristics of AS patients in Qatar are revealed. Similar to others, there is male predominance. Disease activity and functional status were found to be low which may be due to high frequency of patients receiving biologics
Impact of Exogenously Sprayed Antioxidants on Physio-Biochemical, Agronomic, and Quality Parameters of Potato in Salt-Affected Soil
No full textSalinity is one of the harsh environmental stresses that destructively impact potato growth and production, particularly in arid regions. Exogenously applied safe–efficient materials is a vital approach for ameliorating plant growth, productivity, and quality under salinity stress. This study aimed at investigating the impact of foliar spray using folic acid (FA), ascorbic acid (AA), and salicylic acid (SA) at different concentrations (100, 150, or 200 mg/L) on plant growth, physiochemical ingredients, antioxidant defense system, tuber yield, and quality of potato (Solanum tuberosum L cv. Spunta) grown in salt-affected soil (EC = 7.14 dS/m) during two growing seasons. The exogenously applied antioxidant materials (FA, AA, and SA) significantly enhanced growth attributes (plant height, shoot fresh and dry weight, and leaves area), photosynthetic pigments (chlorophyll a and b and carotenoids), gas exchange (net photosynthetic rate, Pn; transpiration rate, Tr; and stomatal conductance, gs), nutrient content (N, P, and K), K+/ Na+ ratio, nonenzymatic antioxidant compounds (proline and soluble sugar content), enzymatic antioxidants (catalase (CAT), peroxidase (POX), superoxide dismutase (SOD), and ascorbate peroxidase (APX)) tuber yield traits, and tuber quality (dry matter, protein, starch percentage, total carbohydrates, and sugars percentage) compared with untreated plants in both seasons. Otherwise, exogenous application significantly decreased Na+ and Cl− compared to the untreated control under salt stress conditions. Among the assessed treatments, the applied foliar of AA at a rate of 200 mg/L was more effective in promoting salt tolerance, which can be employed in reducing the losses caused by salinity stress in potato grown in salt-affected soils
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