258 research outputs found
sj-docx-1-jcn-10.1177_08830738221078683 - Supplemental material for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts
No full textSupplemental material, sj-docx-1-jcn-10.1177_08830738221078683 for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts by Abdelrahim A. Sadek, Mohammed A. Aladawy, Tarek M. M. Mansour, Mohamed F. Ibrahim, Montaser M. Mohamed, Eman F. Gad, Amr A. Othman, Hosny A. Ahmed, Abdin K. Kasim, Wael M. Wagdy, Mohamed H. T. Hasan and Elsayed Abdelkreem in Journal of Child Neurology</p
sj-docx-2-jcn-10.1177_08830738221078683 - Supplemental material for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts
No full textSupplemental material, sj-docx-2-jcn-10.1177_08830738221078683 for Clinicoradiologic Correlation in 22 Egyptian Children With Megalencephalic Leukoencephalopathy With Subcortical Cysts by Abdelrahim A. Sadek, Mohammed A. Aladawy, Tarek M. M. Mansour, Mohamed F. Ibrahim, Montaser M. Mohamed, Eman F. Gad, Amr A. Othman, Hosny A. Ahmed, Abdin K. Kasim, Wael M. Wagdy, Mohamed H. T. Hasan and Elsayed Abdelkreem in Journal of Child Neurology</p
A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug
Full text linkBackground: Elevated plasma triglycerides (TGs) are widely used as a major cardiovascular risk predictor and are thought to play an important role in the progression of coronary heart disease (CHD). It has been demonstrated that lipid lowering was associated with lower mortality in patients with CHD. The present study therefore aimed to investigate the consequences of the genetic variant c.553G>T (rs2075291) in apolipoprotein A5 gene to determination of triglycerides levels in CAD patients receiving, atorvastatin, lipid lowering drug. Methods: We here report that a recently identified genetic variant, c.553G>T in the APOA5 gene which causes a substitution of a cysteine for a glycine residue at amino acid residue 185(G185C) is also associated with increased TG levels. To investigate theses effects, a case-control study compressing 608 subjects from the same area was performed.ResultsTG levels in T allele patients were significantly lower than the control GT allele patient ((2)=2.382E2(a), P-value T variant (rs2075291); in APOA5 gene increases human plasma TG levels. Conclusion: Nevertheless, T allele is found to reduce TG levels in CAD patients who are on the cholesterol medication, atorvastatin. Thus, c.553G>T variant can be considered as a significant predicator of hypertriglyceridemia. In addition, it could be used as a hallmark for the diagnosis and prognosis of CAD
Seasonal COP of a residential magnetocaloric heat pump based on MnFePSi
No full textThe performance of a magnetocaloric heat pump (MCHP) consisting of active magnetocaloric regenerators (AMR) of 12 layers of MnFePSi magnetocaloric materials (MCM) with a linear distribution of Curie temperatures was investigated using a 1D numerical model. The model predicted the heating power and coefficient of performance (COP) of the AMR for a fixed temperature span of 27 K, between 281 K and 308 K, and variable flow rate and AMR cycle frequency. A maximum applied magnetic field strength of 1.4 T was used. A well-insulated house with a maximum heating power demand of 3 kW (under quasi steady state conditions) was considered. Ambient temperature in The Netherlands was taken as a reference for the estimation of the seasonal heating power demand. Without optimizing the design of the AMR, the model predicts a maximum single-AMR heating power equal to 43.5 W when the AMR operates at 3 Hz and 3 L min-1, and a maximum COP equal to 5.8 when it operates at 1.5 Hz and 1 L min-1 Considering the maximum heating power of a single AMR, approximately 69 AMRs are needed to provide the design heating power demand of the house. It was found that it is possible to achieve an AMR seasonal COP of 5.6 by continuously adjusting the flow rate and frequency of operation of the MCHP along with the ON/OFF switching of some groups of AMRs in order to adjust the heating power of the MCHP to the heating power demand of the house.RST/Fundamental Aspects of Materials and EnergyEngineering ThermodynamicsRST/Radiation, Science and Technolog
The contingent factors that affect the use of performance measurement systems in the Egyptian medium and large sized manufacturing companies
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The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance: An AMR Insights global perspective
Full text linkCopyright © The Author(s) 2021. The COVID-19 pandemic presents a serious public health challenge in all countries. However, repercussions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on future global health are still being investigated, including the pandemic’s potential effect on the emergence and spread of global antimicrobial resistance (AMR). Critically ill COVID-19 patients may develop severe complications, which may predispose patients to infection with nosocomial bacterial and/or fungal pathogens, requiring the extensive use of antibiotics. However, antibiotics may also be inappropriately used in milder cases of COVID-19 infection. Further, concerns such as increased biocide use, antimicrobial stewardship/infection control, AMR awareness, the need for diagnostics (including rapid and point-of-care diagnostics) and the usefulness of vaccination could all be components shaping the influence of the COVID-19 pandemic. In this publication, the authors present a brief overview of the COVID-19 pandemic and associated issues that could influence the pandemic’s effect on global AMR
Herd-level relationship between antimicrobial use and presence or absence of antimicrobial resistance in gram-negative bovine mastitis pathogens on Canadian dairy farms
No full textConcurrent data on antimicrobial use (AMU) and resistance are needed to contain antimicrobial resistance (AMR) in bacteria. The present study examined a herd-level association between AMU and AMR in Escherichia coli (n=394) and Klebsiella species (n=139) isolated from bovine intramammary infections and mastitis cases on 89 dairy farms in 4 regions of Canada [Alberta, Ontario, Québec, and Maritime Provinces (Prince Edward Island, Nova Scotia, and New Brunswick)]. Antimicrobial use data were collected using inventory of empty antimicrobial containers and antimicrobial drug use rate was calculated to quantify herd-level AMU. Minimum inhibitory concentrations (MIC) were determined using Sensititre National Antimicrobial Resistance Monitoring System (NARMS) gram-negative MIC plate (Trek Diagnostic Systems Inc., Cleveland, OH). Isolates were classified as susceptible, intermediate, or resistant. Intermediate and resistant category isolates were combined to form an AMR category, and multivariable logistic regression models were built to determine herd-level odds of AMR to tetracycline, ampicillin, cefoxitin, chloramphenicol, trimethoprim-sulfamethoxazole combination, sulfisoxazole, streptomycin and kanamycin in E. coli isolates. In the case of Klebsiella species isolates, logistic regression models were built for tetracycline and sulfisoxazole; however, no associations between AMU and AMR in Klebsiella species were observed. Ampicillin-intermediate or -resistant E. coli isolates were associated with herds that used intramammarily administered cloxacillin, penicillin-novobiocin combination, and cephapirin used for dry cow therapy [odds ratios (OR)=26, 32, and 189, respectively], and intramammary ceftiofur administered for lactating cow therapy and systemically administered penicillin (OR=162 and 2.7, respectively). Use of systemically administered penicillin on a dairy farm was associated with tetracycline and streptomycin-intermediate or -resistant E. coli isolates (OR=5.6 and 2.8, respectively). Use of cephapirin and cloxacillin administered intramammarily for dry cow therapy was associated with increasing odds of having at least 1 kanamycin-intermediate or -resistant E. coli isolate at a farm (OR=8.7 and 9.3, respectively). Use of systemically administered tetracycline and ceftiofur was associated with cefoxitin-intermediate or -resistant E. coli (OR=0.13 and 0.16, respectively); however, the odds of a dairy herd having at least 1 cefoxitin-intermediate or -resistant E. coli isolate due to systemically administered ceftiofur increased with increasing average herd parity (OR=3.1). Association between herd-level AMU and AMR in bovine mastitis coliforms was observed for certain antimicrobials. Differences in AMR between different barn types and geographical regions were not observed
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How is corporate social responsibility adopted by managers? The contribution of ethnography
No full textThis short paper details the ethnographic research processes of access and rapport that are outcomes of PhD research on the topic of corporate social responsibility (CSR). The reason for detailing these processes is twofold. Firstly, I argue that the contribution of ethnography to CSR research is simply the question: how is CSR adopted by managers? Secondly, an ethnographer must convince in their interpretation that the research is valid and useful to the subject of research. In this particular case, that the method of research and how it is communicated are significant for the better understanding of CSR. This paper inductively concludes that one (or the first) contribution of ethnography to CSR is simply that the causes of individual action in the 'institutional and structural order of society' (Webb, 2006 p.4) are over-looked and under-researched
More than a cognitive experience: unfamiliarity, invalidation, and emotion in organizational learning
No full textLiterature on organizational learning (OL) lacks an integrative framework that captures the emotions involved as OL proceeds. Drawing on personal construct theory, we suggest that organizations learn where their members reconstrue meaning around questions of strategic significance for the organization. In this 5-year study of an electronics company, we explore the way in which emotions change as members perceive progress or a lack of progress around strategic themes. Our framework also takes into account whether OL involves experiences that are familiar or unfamiliar and the implications for emotions. We detected similar patterns of emotion arising over time for three different themes in our data, thereby adding to OL perspectives that are predominantly cognitive in orientation
Autonomous hierarchical adaptive mesh refinement for multiscale simulations
No full textModern high-resolution numerical simulations of multiscale physical phenomena require enormous computer resources; however, these resources are largely wasted on subdomains whose solutions do not require such high resolutions. Adaptive mesh refinement (AMR) addresses this problem by providing a means to perform high-resolution computation only in areas that require it. In the AMR strategy discussed, a nested hierarchy of overlaying grids of increasingly fine resolution--in both space and time--permits high resolution computation in some areas and low resolution in others, either as a set of virtual grids, each encompassing the entire domain, or as a means of zooming in on a subdomain of interest. However, this AMR strategy is both subtle and cumbersome to code, and its data requirements are difficult to manage in a general way. To address this shortcoming, the Hierarchical Adaptive Mesh Refinement (HAMR) system provides support not only for AMR, but also for autonomous data management, thereby decoupling the numerical techniques of a simulation from the adaptive grid hierarchy to which it is applied.Made available in DSpace on 2011-05-07T13:02:03Z (GMT). No. of bitstreams: 2
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