170,195 research outputs found
Elphick, C V, WX4730
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/383898Surname: ELPHICK. Given Name(s) or Initials: C V. Military Service Number or Last Known Location: WX4730. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 6117.228133
Item: [2016.0049.16191] "Elphick, C V, WX4730
Correlation of microseismic and chemical properties of brittle deformation in Locharbriggs sandstone
No full textThe time-dependent properties of ceramic materials such as rocks depend both on preexisting cracks and chemical properties acting at their tips. We have examined the direct effect of chemical processes on the growth of a crack population by carrying out triaxial flow-through compression tests on Locharbriggs sandstone. The tests were carried out at temperatures of 25–80°C and at strain rates ranging from 10−5 to 10−8 s−1 under constant stress rate loading. The exit pore fluid was analyzed after the tests for the concentration of dissolved ions and acoustic emission was monitored in real time throughout the tests. The exit pore fluid silica concentration and microcrack damage derived from the acoustic emission (AE) data both exhibited an exponential increase during the strain hardening phase of deformation. Damage parameters inferred from the AE data predict the stress-strain curves adequately, or at least up to the point of strong microcrack coalescence. The damage parameters and silica signal were strongly correlated by a power law relationship. The observed environment and strain rate dependence of mechanical properties can hence be attributed uniquely to time-dependent crack growth by the stress corrosion mechanism
The Evolution and Diversity of SALMFamide Neuropeptides
No full textThe SALMFamides are a family of neuropeptides that act as muscle relaxants in echinoderms. Two types of SALMFamides have been identified: L-type (e.g. the starfish neuropeptides S1 and S2) with the C-terminal motif LxFamide (x is variable) and F-type with the C-terminal motif FxFamide. In the sea urchin Strongylocentrotus purpuratus (class Echinoidea) there are two SALMFamide genes, one encoding L-type SALMFamides and a second encoding F-type SALMFamides, but hitherto it was not known if this applies to other echinoderms. Here we report the identification of SALMFamide genes in the sea cucumber Apostichopus japonicus (class Holothuroidea) and the starfish Patiria miniata (class Asteroidea). In both species there are two SALMFamide genes: one gene encoding L-type SALMFamides (e.g. S1 in P. miniata) and a second gene encoding F-type SALMFamides plus one or more L-type SALMFamides (e.g. S2-like peptide in P. miniata). Thus, the ancestry of the two SALMFamide gene types traces back to the common ancestor of echinoids, holothurians and asteroids, although it is not clear if the occurrence of L-type peptides in F-type SALMFamide precursors is an ancestral or derived character. The gene sequences also reveal a remarkable diversity of SALMFamide neuropeptides. Originally just two peptides (S1 and S2) were isolated from starfish but now we find that in P. miniata, for example, there are sixteen putative SALMFamide neuropeptides. Thus, the SALMFamides would be a good model system for experimental analysis of the physiological significance of neuropeptide "cocktails" derived from the same precursor protein
The Protein Precursors of Peptides That Affect the Mechanics of Connective Tissue and/or Muscle in the Echinoderm Apostichopus japonicus
No full textPMCID: PMC3432112This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Supervising Offline Partial Evaluation of Logic Programs using Online Techniques
No full textA major impediment for more widespread use of offline partial evaluation is the difficulty of obtaining and maintaining annotations for larger, realistic programs. Existing automatic binding-time analyses still only have limited applicability and annotations often have to be created or improved and maintained by hand, leading to errors. We present a technique to help overcome this problem by using online control techniques which supervise the specialisation process in order to help the development and maintenance of correct annotations by identifying errors. We discuss an implementation in the Logen system and show on a series of examples that this approach is effective: very few false alarms were raised while infinite loops were detected quickly. We also present the integration of this technique into a web interface, which highlights problematic annotations directly in the source code. A method to automatically fix incorrect annotations is presented, allowing the approach to be also used as a pragmatic binding time analysis. Finally we show how our method can be used for efficiently locating built-in errors in Prolog source code
Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease
No full textThe endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD). However, the association between CB1 alterations and the development of AD neuropathology is unclear and often contradictory. In this study, brain CB1 mRNA and CB1 protein levels were analyzed in 3 × Tg-AD mice and compared to wild-type littermates at 2, 6 and 12 months of age, using in-situ hybridization and immunohistochemistry, respectively. Semiquantitative analysis of CB1 expression focused on the prefrontal cortex (PFC), prelimbic cortex, dorsal hippocampus (DH), basolateral amygdala complex (BLA), and ventral hippocampus (VH), all areas with high CB1 densities that are strongly affected by neuropathology in 3 × Tg-AD mice. At 2 months of age, there was no change in CB1 mRNA and protein levels in 3 × Tg-AD mice compared to Non-Tg mice in all brain areas analyzed. However, at 6 and 12 months of age, CB1 mRNA levels were significantly higher in PFC, DH, and BLA, and lower in VH in 3 × Tg-AD mice compared to wild-type littermates. CB1 immunohistochemistry revealed that CB1 protein expression was unchanged in 3 × Tg-AD at 2 and 6 months of age, while a significant decrease in CB1 receptor immunoreactivity was detected in the BLA and DH of 12-month-old 3 × Tg-AD mice, with no sign of alteration in other brain areas. The altered CB1 levels appear, rather, to be age-and/or pathology-dependent, indicating an involvement of the endocannabinoid system in AD pathology and supporting the ECS as a potential novel therapeutic target for treatment of AD
The evolution of neuropeptide signalling: insights from echinoderms
No full textThis work was supported by Leverhulme Trust grant RGP-2013-351 and BBSRC grant BB/M001644/1 (awarded to M.R.E.).
Dean Semmens has a BSc in Molecular and Cellular Biology (University of Bath, 2011), a PhD in Neurobiology (Queen Mary University of London, 2015) and is a Leverhulme Trust-funded Postdoctoral Fellow.
Maurice Elphick studied at Royal Holloway University of London (BSc Biology, 1988; PhD Neurobiology, 1991) and became Professor of Physiology and Neuroscience at Queen Mary University of London in 2004
Ecology and conservation of birds in rice fields: a global review.Waterbirds 33, Special Publication 1, Pp. 246 +IV.
No full textEvolution and comparative physiology of luqin-type neuropeptide signaling
No full textLuqin is a neuropeptide that was discovered and named on account of its expression in left upper quadrant cells of the abdominal ganglion in the mollusc Aplysia californica. Subsequently, luqin-type peptides were identified as cardio-excitatory neuropeptides in other molluscs and a cognate receptor was discovered in the pond snail Lymnaea stagnalis. Phylogenetic analyses have revealed that orthologs of molluscan luqin-type neuropeptides occur in other phyla; these include neuropeptides in ecdysozoans (arthropods, nematodes) that have a C-terminal RYamide motif (RYamides) and neuropeptides in ambulacrarians (echinoderms, hemichordates) that have a C-terminal RWamide motif (RWamides). Furthermore, precursors of luqin-type neuropeptides typically have a conserved C-terminal motif containing two cysteine residues, although the functional significance of this is unknown. Consistent with the orthology of the neuropeptides and their precursors, phylogenetic and pharmacological studies have revealed that orthologous G-protein coupled receptors (GPCRs) mediate effects of luqin-type neuropeptides in spiralians, ecdysozoans, and ambulacrarians. Luqin-type signaling originated in a common ancestor of the Bilateria as a paralog of tachykinin-type signaling but, unlike tachykinin-type signaling, luqin-type signaling was lost in chordates. This may largely explain why luqin-type signaling has received less attention than many other neuropeptide signaling systems. However, insights into the physiological actions of luqin-type neuropeptides (RYamides) in ecdysozoans have been reported recently, with roles in regulation of feeding and diuresis revealed in insects and roles in regulation of feeding, egg laying, locomotion, and lifespan revealed in the nematode Caenorhabditis elegans. Furthermore, characterization of a luqin-type neuropeptide in the starfish Asterias rubens (phylum Echinodermata) has provided the first insights into the physiological roles of luqin-type signaling in a deuterostome. In conclusion, although luqin was discovered in Aplysia over 30 years ago, there is still much to be learnt about luqin-type neuropeptide signaling. This will be facilitated in the post-genomic era by the emerging opportunities for experimental studies on a variety of invertebrate taxa.</p
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