41 research outputs found
Comment on "Pathophysiology of migraine" by professor PJ Goadsby in August 2012 edition of Ann Indian Acad Neurol
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A method for determining when the superficial scalp arteries are the source of migraine pain
No full textIn some patients the pain of migraine originates in the extracranial cranial arteries. This article describes the location and a logical examination sequence of the vessels most frequently involved in migraine pain
Comments on the review article ‘Antidromic vasodilatation and the migraine mechanism’ by Geppetti et al in the Journal of Headache and Pain 2012; 13:103–111
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The Role of the External Carotid Vasculature in Migraine
No full textAbstract The pathogenesis of migraine pain has not yet been adequately explained and remains the subject of vigorous debate. Early studies by Harold Wolff and his associates on the extracranial terminal branches of the external carotid artery provided compelling evidence of their involvement in the evolution of migraine pain. They postulated that migraine pain emanates from dilated extracranial arteries. Since 1958, however, when Milner proposed that the visual aura of migraine may be caused by the "spreading depression" of Leão, migraine research has focused almost exclusively on the central neurovascular changes, to the exclusion of Wolff's postulates. Current theories implicate changes in the trigeminovascular system, which is defined as comprising the trigeminal subnucleus caudalis, the trigeminal nerve, and the intracranial arteries, particularly the middle meningeal artery. Although the middle meningeal artery is intracranial, it is one of the terminal branches of the external carotid artery. In this chapter experimental, clinical, and pharmacological evidence linking the extracranial terminal branches of the external carotid artery to migraine pain is presented
