43 research outputs found

    Here comes the big brass band

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    Ditty about parade at Mardi Gras celebrationMarilyn Edwards, Angela Drake and Lillian Robere, "The History and Development of St. Lawrence" - an O.V.F. Project, p. 46

    CHRONONYMS AND LOCONYMS AS REFLECTION OF CULTURAL TRANSFORMATIONS IN RUSSIAN DITTIES

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    Folklore is a form of reflection of national collective consciousness, emotional perception of the world, axiological attitudes, and it is of particular interest for the study. A ditty (chastushka) is one of the few genres of folklore, which functions and develops in modern linguistic culture, changing under the influence of extralinguistic factors. It shows a rapid reaction in response to everything that happens in our society, transferring the attitude of the cumulative linguistic personality to the events of social, economic, and political situation in the country and the world in the traditional form of two-line or four-line rhymed poem ditty on some topical or humorous theme. In many ways, this popularity of the genre is due to the special representation of the basic concepts of. Space. and. Time.. Despite the relatively recent time of becoming an independent genre of folk art (mid-nineteenth century), ditties quickly gained popularity and remains an actively developing genre in our days. In the modern anthropocentric paradigm of philological research, the text of ditties is of a particular interest, and this is due to the fact that the author of ditties is a cumulative linguistic personality, it provides a better understanding of the subtleties of changes in ethnolinguistic consciousness over time. In this article we would like to consider some verbal means of realization of two fundamental non-discursive folklore concepts "Time" and "Space" in the Russian ditties and on this material to trace the sociological and cultural transformations.. (C) 2019 Published by Future Academy www.FutureAcademy.org.U

    Abstract 2894: XMT-1592, a site-specific Dolasynthen-based NaPi2b-targeted antibody-drug conjugate for the treatment of ovarian cancer and lung adenocarcinoma

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    Abstract The Dolasynthen platform incorporates the highly potent anti-mitotic agent auristatin F-HPA (AF-HPA), with its associated DolaLock mechanism of controlled bystander effect, and enables the synthesis of antibody-drug conjugates (ADCs) with precise control of the drug-to-antibody ratio (DAR) and site-specific bioconjugation. XMT-1592 is a novel ADC comprised of an anti-NaPi2b antibody and Dolasynthen, conjugated in a site-specific manner to yield DAR 6. NaPi2b, also known as SLC34A2, is a transmembrane sodium-phosphate transporter that is broadly expressed on tumor cells in ovarian carcinoma, NSCLC lung adenocarcinoma and other tumor types. Recent studies have shown that NaPi2b expression is enriched in the EGFR and KRAS mutant subtypes of lung adenocarcinoma. Binding studies showed a specific, high-affinity interaction of XMT-1592 with NaPi2b that was not affected by conjugated Dolasynthen. XMT-1592 elicited potent and specific in vitro cytotoxicity against NaPi2b-expressing ovarian carcinoma cells. XMT-1592 exhibited potent and specific in vivo activity in NaPi2b-expressing tumor xenografts derived from ovarian carcinoma or lung adenocarcinoma. Consistent with the targeted delivery benefits of the ADC approach, XMT-1592 yielded high and sustained concentrations of AF-HPA to tumors but not normal tissues. To evaluate the benefits of site-specific bioconjugation of Dolasynthen, we conducted in vitro and in vivo comparisons of XMT-1592 to a stochastically conjugated version of the ADC. XMT-1592 had improved in vivo activity, pharmacokinetics, and clinical pathology relative to its stochastic counterpart. Taken together, these results support XMT-1592 as a development candidate for the treatment of NaPi2b-expressing tumors. Citation Format: Shawn Fessler, Anouk Dirksen, Scott D. Collins, Ling Xu, Winnie Lee, Jason Wang, Ron Eydelloth, Elena Ter-Ovanesyen, Jeffrey Zurita, Elizabeth Ditty, Barrett Nehilla, Susan Clardy, Susan Clardy, Tyler Carter, Kenneth Avocetien, Mark Nazzaro, Nam Le, Kalli C. Catcott, Alex Uttard, Bingfan Du, Chen-Ni Chin, Rebecca Mosher, Kelly Slocum, Liuliang Qin, David Lee, Dorin Toader, Marc Damelin, Timothy B. Lowinger. XMT-1592, a site-specific Dolasynthen-based NaPi2b-targeted antibody-drug conjugate for the treatment of ovarian cancer and lung adenocarcinoma [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2894

    Mark M. Michalski: Editorial

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    The Journal of Business and Public Administration wel-comes and is pleased to introduce two new Editors: Dr Jaro-slaw Wenancjusz Przybytniowski of the Department of Man-agement at Jan Kochanowski University as an Academic (Theme) Editor and Dr Dominik Dziekanski of Economic Department at Jan Kochanowski University as a Technical Editor.Journal opens with an article by professor Przybyt-niowski, titled: Competitiveness of financial distribution channels in the time of the ongoing crisis. It presents an as-sessment of service provision by insurance companies. The author shows a critical link between customers’ expectations and relationship management as of paramount importance in cultivating loyalty and continuous flow of profitable busi-ness. Just as a ditty tells us: there is no better business than repeat business. Insurance companies form a system of channels to provide the insurance services in the most opti-mal way to achieve their own goals. They allow the potential customers to use the services of channels with which the in-surance company distributes its products. Managing cus-tomer relationships is an important element of nurture loy-alty. However, it must be accompanied by appropriate measures to maintain the relationship at every level of or-ganization. The aim of this article is to analyze the insurance market in Poland from side of insurance an insurance medi-ation

    1997 Sub-Librarians Meeting: Sleuths on the Screen

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    Marsha Pollak and Robert Steele welcomed the Sub-Librarians to the Holiday Inn for afternoon tea once again and reminded them to take a look at the shadow boxes representing Sherlockian stories and the re-creation of 221B sitting room after the program. Greetings from various scions were given: Steele from the Scowrers and Molly Maguires, Michael Kean from the Diogenes Club of Monterey, and Ray de Groat of the Persian Slipper Club. Everyone then stood and sang God Save the Queen. The traditional toasts were given to Sherlock Holmes, to Lomax by Maxine Reneker, to Hill Barton by Don Yates, to Baron Gruner by Frank Sadowsky, and to Kitty Winter by Rosemary Michaud. This last was a particularly rousing ditty, a tribute in song to Kitty, sung expressively by Michaud. Our first speaker, Ron Miller, is the award winning, syndicated television columnist for The San Jose Mercury News. The author of Mystery! A Celebration: Stalking Public Television\u27s Greatest Sleuths, he spoke on detectives on the small screen. Paula Brown, our next speaker, is a well-known Sherlockian who started a scion called The Noble West Enders. Paula is an expert on, and paid tribute to, the late Jeremy Brett, portrayer of Holmes on Mystery! The meeting ended with the singing of A Song for Sub-Librarians and the reading of Vincent Starrett\u27s poem 221B. Many then walked across the hall to the S.Holmes Esq. Pub for a drink and more conversation

    Milestones Mark 50-Year Story

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    Newspaper Article - 'Milestones Mark 50-Year Story'. The Edmonton Journal, May 29, 1959. Milestones down the 50-year road of the Alberta Women's Institute.AWI CollectionWi Jubilee Anniversary Milestones Mark 50- Year Story 2Jhe lE& mnnfnn 31m SECTION TWO EDMONTON, ALBERTA, FRIDAY, MAY 29, 1959 Milestones down the 50- year road of the Alberta Women's Institutes indicate the organ­ization is on a broad highway after starting down a narrow path, from past presidents' reminiscences at the jubilee convention meeting in Convo­cation Hall Thursday evening. Projects have expanded, hori­zons broadened and the or­ganization has repeatedly sent representatives to the conven­tions of the Associated Country Women of the World. The story told Thursday evening by special speaker,. Miss Isabel Noble of Wichita, Kansas, organizer of the WI in 1909 and president for the first eight years, was of a neb­ulous beginning. WITHIN 50 TEARS Fifty years later, Mrs. T. H. Howes, Millet, completing her term as president, attended the ACWW meeting in Ceylon and the immediate past president, Mrs. S. Lefsrud, Viking, who also attended an ACWW con­ference in Toronto, referred to a recent trip she made to Rus­sia. Between the beginning at home and the world viewpoint, the convention relived their activities in reports of presi­dents who served during war years and depression. The story took the audience on many ad­ventures along Alberta's early highways as the presidents travelled to unite the scattered branches of the WI. Speakers included Mrs. W. McParlane who read a report from Mrs. A. G. McGorman, Penhold. president from 1R49 to 1953. and Airs. M. L. Thomp­son. Lethbridge, president from 1941 to 1945. On behalf of Mrs. Susan D. Stewart of Peace River, presi­dent from 1937 to 1941, Mrs. A. H. Rogers was the speaker. Mrs. J. C. Ferguson, Trochu, president from 1933 to 1937 also addressed the meeting. The past presidents paid tribute to the tremendous ac­complishments of the late Mrs. E. E. Morton, Vegreville, presi­dent from 1945 to 1949. Mrs. M. G. Roberts of Hanna was chairman. BORROWED CONSTITUTION Telling of the organization days of the WI Miss Noble, the special speaker said, " I thought constitutions were for quarrelsome people." recalling how at first the WI worked on an adopted constitution from when she travelled south giving demonstrations on c a n n i ng vegetables. In one district the women arrived, some two on a horse, some carrying shoes and S t o c k i n g s . This is a poor district, she thought, but went ahead with her talk to a most indifferent audience. Question time came and they asked why ahe spoke in that vein when they hadn't had a crop in asven years. Nor had they the money to pool together to buy vegetables. Help? Send us a nurse they urged, and so rural organization was begun to supply district nurses. Miss Noble's talk was a gay remembrance of anecdote in the early days. She also cited distress cases where the WI helped as neighbors. WI CREED ' " sHeToIcTof how the creed of the WI now repeated the world over, was given first to her by a neighbor in Daysland, her Alberta home, before she mov­ed to Wichita. " I have heard t h a t creed repeated in Britain and in Asia," she said. During her term as president. 1933 to 1937 there were hard times and poverty, Mrs. J. C. Ferguson of Trochu reminded. She recalled how the WI help­ed supply layettes for mothers in need, and referred to a visit from Lady Tweedsmuir when a WI library for shipping pack­ages of books to rural homes was inaugurated. Mrs. Rogers' message from Mrs. Stewart of Peace River was a lively account of how the graduate of Glasgow University came as a bride to Peace River, and took up WI work. She served as AWI president from 1937 to 1941. Later her war ef­fort was to work ih Ottawa censoring German mail. Offered the presidency of the Feder­ated WI of Canada she re­fused " because it was not Al­berta's turn." WAR SERVICE Mrs. Thompson recalled the work of the WI during the war years; service for the Red Cross, making ditty bags for th « merchant marine; how they cancelled a convention and bought bonds with the money saved; how they saved a dollar each in Christmas money, and sent $ 1,000 to sister Wis in bombed areas in Britain. RUSSIA, PIONEERING Mrs. Lefsrud's description of the ACWW meeting in Toronto turned then to her personal trip to Russia which she saw, she said, as a pioneer country with the people looking ahead. Moscow she said was a fascin­ating metropolis. She urged that the four freedoms in the coven­ant of the ACWW, freedom from want, freedom of thought, speech and expression be re­membered in judging Russia. Milestones In her presidency included taking up the cause of Alberta's Indians. Speaking on behalf of Mrs. W. McGorman, Red Deer, Mrs. W. McFarlane referred to es­tablishing a scholarship in music in memory of the late Mrs. H. J. Montgomery, presi­dent from 1929 to 1933, and of obtaining sponsors for handi­crafts. Mrs. McGorman was a delegate to the ACWW confer­ence in Copenhagen, Denmark during her presidency. During the evening Miss Jeanette MacDonall, winner of the first Montgomery scholar­ship, sang several selections. Gifts were presented by Mrs. Howes to Mrs. A. H. Rogers and to Miss MacDonall. Mrs. Howes also presented a life membership pin to Mrs. Per-, guson, Trochu. The meeting concluded with roll call of branches and a cof­fee party at which the AWI cut and served their annivers­ary cake. NEW OFFICERS IN AWI — The con­cluding day, Friday, of the Alberta Women's Institutes' four- day convention brought elec­tions at the morning sessions at Convocation Hall. Mrs. W. R. Ford, Coutts, Alberta, pic­tured at centre, was elected preside M. G. Roberts, Drumheller, left, w vice- president and Mrs. John Rich Deer, secretary. — Photo by Goe

    Minimizing impracticality of complex modeling via web service execution within a cloud-based platform

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    2015 Spring.Includes bibliographical references.Assessing the stability of stream banks is an important issue for those living within a floodplain, participating in activities such as hunting, rafting, and fishing, and for transporting water from one place to another safely. A stream’s stability is influenced by frequency and magnitude of streamflow, particle size, sediment transport, bed slope, and depth of the water (Allen, P.M., Arnold, J.G., Stinchcomb, 2012). Streams of all sizes adapt to streamflow regimes by continually altering channel properties such as channel’s shape and channel depth. As a result, assessing stream stability requires quantifying hydrologic factors that influence the stream’s shape and depth, especially under conditions of urbanization. Changes in climate and land use further complicate assessing a stream’s stability. This complication is due partly to humanity’s knowledge gaps or negligence in maintaining solutions of existing infrastructure (Vijay P. Singh, 2002). The most common cause of stream instability is the increase in surface runoff entering a stream due to urbanization. Engineers use models as a tool to help manage, address, or mitigate problems such as increasing surface runoff entering the streams. The primary goal of this research is to integrate an existing model (SWAT-DEG) as a web-based modeling tool to assess the hydrologic response to changes in climate and land use. Specific objectives of the study are: 1. To compliment an existing model by integrating the model into service oriented architecture. 2. To compliment an existing model by deploying a model utilizing web-services. 3. To explore the benefits of deploying an existing model as a web-based tool within a service-oriented architecture. Web services provide access to SWAT-DEG at any internet-accessible location, limits version control, independent of operating system, and eliminate desktop installations. Currently, SWAT-DEG is hosted by eRAMS.com’ (eRAMS) platform. eRAMS is an internet site that hosts and executes various models. The model is executed within a cloud environment to ensure the model can scale to increasing, simultaneous users. The cloud environment obtains scalable models by reducing the total time per request for a given model. The total time per request is defined as the time that elapses from when the user executes a function till the function is completed. For example, the total time per request spent for executing a model is the time spent between clicking run and the return of output from the model. To accomplish a reduction in total time per request, the execution of SWAT-DEG is parallelized within Cloud Services Innovation Platform (CSIP) (Lloyd, W, David, O, Lyon, J, Rojas, K.W., Ascough II, J.C., Green, T.R., Carlson, J.R., 2012) CSIP is a cloud infrastructure trying to implement modeling-as-a-service. Modeling-as-a-service is an attempt to provide the ability to scale various web-based models for large amounts of simultaneous users and/or expensive computational models. SWAT-DEG is broken up into two separate main functions within the source code, stochastic and deterministic. The stochastic part of SWAT-DEG executes the Monte Carlo (Ronald iii Christensen, Wesley Johnson, Adam Branscum, 2011; Yang, 2011) approach as the means to do uncertainty analysis. The deterministic approach is the same as the desktop version of SWAT-DEG. Scalability testing was applied to SWAT-DEG’s stochastic and deterministic services. The deterministic service showed clear benefits when executing multiple simultaneous users within the CSIP environment. However, a single user executing a deterministic service on the cloud is slower than a local computer. The stochastic service also saw a slight benefit from executing within the CSIP environment. The stochastic service did not receive a greater benefit due to a bottleneck in the output map reduction. Output map reduction is the process of taking multiple files and reducing them to a manageable size. SWAT-DEG processes this phase within one virtual machine (VM). A virtual machine is an online computer processor unit. Thus, by removing the limitation of executing map reduction within one VM, executing stochastic analysis within the cloud environment will result in far smaller total time per request

    Iowa History and Culture : A Bibliography of Materials Published Between 1952 and 1986, 1989

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    This bibliography was compiled by two reference librarians, Patricia Dawson and David Hudson with the goal of making it easier of tracking down material on Iowa history and culture. This supplements the Iowa History Reference Guide published in 1952 by William Petersen
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