69 research outputs found
Fonti per la storia della Toscana / 6: Dizionario geografico fisico storico della Toscana (Repetti online)
No full textSegnaliamo la versione informatizzata del Dizionario geografico fisico storico della Toscana di Emauele Repetti (1776-1852), progetto a cura del Dipartimento di archeologia e storia delle arti dell'Università di Siena. Il Dizionario, considerato una fonte di primaria importanza per lo studio del territorio, fu pubblicato prima in fascicoli e in seguito, tra il 1832 e il 1845, venne stampato in 6 volumi a Firenze presso l’Autore. Fin dall’uscita dei primi fascicoli, l’opera fu accolta con molt..
GIS a tool for 20th Century Architecture. From the territory to the building scale
No full textManagement, organization, and dissemination of data represent today one of the main topics of heritage protection and enhancement. Through four case studies, this contribution describes the use of GIS (Geographic Information System) applied to 20th century architecture, as a tool for critical analysis of data and their possible use for the design phase. The examination of the case studies highlights opportunities and limits of a peculiar use of GIS in the field of 20th century architecture, taking into consideration its specific features. Investigations developed at territorial, urban and building scale demonstrate GIS strengths and weaknesses for the improvement of projects on existing buildings
Il GIS per la valorizzazione dell'architettura del '900: dalla scala territoriale all'edificio
No full textLa gestione, sistematizzazione e fruizione delle informazioni costituisce oggi uno dei temi fondamentali della tutela e della valorizzazione del patrimonio costruito.
Il testo illustra le diverse possibili operatività del GIS quale strumento per l’analisi critica di dati e il loro potenziale uso nell’ambito progettuale. Vengono presentate applicazioni all’architettura del Novecento e, in particolare a quattro casi studio.
Si evidenziano potenzialità e limiti di un particolare utilizzo del GIS applicato al costruito del XX secolo per la qualificazione del progetto sull’esistente. Partendo da un progetto a scala territoriale, passando per quella urbana, fino ad arrivare a quella dell’edificio, emergono vantaggi, potenzialità e limiti del GIS
Terraced landscape preservation and tourism sustainability in Cinque Terre, Liguria.
No full textCinque Terre terraced landscape represents an example of a peculiar relation between nature and humankind, thanks to its characteristic shaped territory. This area, vulnerable to natural disaster and anthropic degradation, has been involved in several actions aimed at its preservation since the 80s. The site was inscribed in the World Heritage List and various laws and agencies were created to support local agriculture and landscape preservation. Through the analysis of the regulations context and related requirements, this chapter aims to explore the relationship between mass tourism effects and landscape vulnerability, and the conflict between conservation needs and the site’s real economy
Terraced landscape preservation and tourism sustainability in Cinque Terre, Liguria.
No full textCinque Terre terraced landscape represents an example of a peculiar relation between nature and humankind, thanks to its characteristic shaped territory. This area, vulnerable to natural disasters and anthropic degradation, has be en involved in several actionsaimed at its preservation since the 1980s. The site was inscribed in the World Heritage List (WHL) and various laws and agencies were created to support local agriculture and landscape preservation. Through the analysis of the legislative context and related requirements, this chapter aims to explore the relationship between mass tourism effects and landscape vulnerability and the conflict between conservation needs and the site’s real economy
Symposium on Buddhist Perspectives on Free Will: Agentless Agency?
No full textThis special issue of the Journal of Buddhist Ethics, Volume 25, is a symposium on the anthology, Buddhist Perspectives on Free Will: Agentless Agency? (Repetti), and on the topic reflected by that title, more broadly, based on an Author Meets Critics session of the 2018 American Philosophical Association Eastern Division meeting organized by Christian Coseru. To orient readers new to the topic, I first sketch what some of the issues are regarding Buddhist perspectives on free will. Second, I briefly describe the anthology, and third, I introduce the several contributions to this symposium. As I am sympathetic to most of the papers here, I only respond briefly to them in this introduction, giving some reasons for my approval. Two papers here, however, are significantly critical of either the anthology as a whole (Brent), or critical of my contributions to it (Meyers). I respond separately to each of them in the last two papers in the symposium. Together with this introduction, all the included papers are original
Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice
No full textHericium erinaceus (Bull.) Pers. is a medicinal mushroom capable of inducing a large number of modulatory effects on human
physiology ranging from the strengthening of the immune system to the improvement of cognitive functions. In mice, dietary
supplementation with H. erinaceus prevents the impairment of spatial short-term and visual recognition memory in an Alzheimer
model. Intriguingly other neurobiological effects have recently been reported like the effect on neurite outgrowth and differentiation
in PC12 cells. Until now no investigations have been conducted to assess the impact of this dietary supplementation on brain
function in healthy subjects. Therefore, we have faced the problem by considering the effect on cognitive skills and on hippocampal
neurotransmission in wild-type mice. In wild-type mice the oral supplementation with H. erinaceus induces, in behaviour test, a
significant improvement in the recognition memory and, in hippocampal slices, an increase in spontaneous and evoked excitatory
synaptic current in mossy fiber-CA3 synapse. In conclusion, we have produced a series of findings in support of the concept that
H. erinaceus induces a boost effect onto neuronal functions also in nonpathological conditions
Cinque Terre: terraced landscape preservation and tourism sustainability
No full textCinque Terre terraced landscape represents an extraordinary example of the peculiar relation between humankind and nature. For centuries its inhabitants shaped the territory, building a farmed terraced system that has characterized the image and identity of this land until today. This territory, extremely vulnerable to natural disaster and anthropic degradation, has been involved in several actions aimed at its protection and safeguard since the 1980s, through regional laws supporting local agriculture and terraces preservation. The site was inscribed in the World Heritage List as a cultural landscape in 1997 and Cinque Terre National Park was established in 1999. Through the analysis of the existing regulations context, related requirements, touristic data, promotion and strategies, this paper aims to explore the relationship between mass tourism effects and landscape vulnerability, focusing on the conflict existing between sustainability declared, or sought, by the authorities and the risks related to land consumption
Design and develop a 3D printed medical phantom able to replicate lungs and bronchial tree geometrical and mechanical characteristics as human tissue
No full textLung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. Worldwide in 2012, lung cancer occurred in 1.8 million people and resulted in 1.6 million deaths. This makes it the most common cause of cancer-related death in men and the second most common in women after breast cancer. Literature shows how it is difficult to find a proper diagnostic and treatment technique for this problem, especially in an early-stage phase. CT-guided needle aspiration, surgical resection, and bronchoscopy are used for lung cancer treatment, all show encouraging results for the diagnosis and treatment of lung cancer but also limitations and complications. In the past decade, innovations were introduced for bronchoscopy in order to approach, diagnose, and treat the pulmonary lesions in the peripheral areas of the bronchi. Among these, electromagnetic navigation bronchoscopy shows impressive accuracy results in the diagnosis and treatment of these peripheral lesions, but many complications and challenges are present. These complications are mainly associated with the long learning curve for trainers and the slow process of implementing new innovative instruments that could improve the technique. These challenges could be linked with the unavailability of a proper medical real-life model that could mimic both the complex geometrical structure and the physical characteristics of the bronchial tree and lung tissue and could be used as a testing and training environment. For this reason, the main objective of this research is to create a lung model that mimics both the geometrical and mechanical properties of the lung and bronchial tree. The medical phantom was created using additive manufacturing (3D printing) as production technique and polyvinyl alcohol hydrogel as production material. The research approach for this project involved the definition and validation of two main design criteria: mechanical and geometrical. The mechanical criterion was evaluated by preparing and testing different configurations of PVA hydrogels, created via freeze-thawing cycles process, and then compared the mechanical properties of the hydrogel, in particular, the elastic Young Modulus, with data from literature reporting lung tissue elasticity. The geometrical criterion was evaluated by creating a 3D model from CT scans and inspect this model with a bronchoscope and endoscope to identify similarity with real lung anatomy. The analysis of results produced with the experiments confirms the behavior of PVA hydrogel as a biomaterial that could mimic the mechanical properties of organic tissues. In particular, the results confirm the correlation of the mechanical properties of the hydrogel with the number of freeze-thaw cycles and the molecular weight of PVA powder in the solution, as already stated in the literature. In addition to that, a specific hydrogel configuration, with 10wt% of PVA and after four freeze-thaw cycles, was identified as a valuable mimicking material for lung tissue, where the values of the elastic module of the hydrogel match the bronchial tree and lung tissue on different strain levels. Furthermore, the inspection with the bronchoscope shows a similarity between the geometry of the model and the anatomy of the lungs, although just a qualitative analysis was done for validation of the geometrical criterion. Overall, the research goal of this project was satisfied, and the final prototype tested with successfull results. However, this is the first 3D printed lung model created with biomaterials, and different limitations are present.Mechanical Engineering | BioMechanical Desig
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