2,280 research outputs found
Data for: Improved modelling and critical analysis of future electrification pathways: the case of Tanzania
No full textSupplementary material accompanying the paper:Improved modelling and critical analysis of future electrification pathways: the case of TanzaniaMatteo V. Rocco, Elena Fumagalli, Chiara Vigone, Ambrogio Miserocchi, Emanuela ColomboDepartment of Energy, Politecnico di MilanoCopernicus Institute of Sustainable Development, Utrecht UniversityCorresponding author: Via Lambruschini 4, 21056 Milan, Italy. E-mail: [email protected]
William Barnes' s Poems in standard English, translated from the Italian
No full textIl terzo volume delle opere di William Barnes raccoglie le sue traduzioni letterarie da lingue europee e orientali. La parte italiana a cura di E. Di Rocco e E. Spandri comprende testi di Petrarca e Metastasio che vengono commentati in nota e introdotti da una prefazione
Premalignant and pre-invasive lesions of the breast
No full textPremalignant and pre-invasive lesions of the breast belong to a complex and heterogeneous group of lesions and represent a matter of remarkable interest from both clinical and biological standpoints. These frequent noninvasive alterations are related with an increased probability of breast cancer development. What is more, these breast abnormalities show extremely variable risks of progression toward invasive forms of disease. Indeed, while there are many histologically defined premalignant lesions in the breast, only a subset of them constitute true neoplastic precursors that will progress to invasive cancer. Disappointingly, it is currently not conceivable to identify a priori, with absolute certainty, which of these precursors will progress and which not. Therefore, classifying risk indicators, precursors, and non-obligate precursors of invasive breast cancer, and ultimately define robust protocols for their clinical management, is a hot topic in the multidisciplinary approach to breast cancer patients, that involves pathologists, radiologists, surgeons, and oncologists
Advances in Early Breast Cancer Risk Profiling: From Histopathology to Molecular Technologies
No full textEarly breast cancer (BC) is the definition applied to breast-confined tumors with or without
limited involvement of locoregional lymph nodes. While risk stratification is essential for guiding
clinical decisions, it can be a complex endeavor in these patients due to the absence of comprehensive
guidelines. Histopathological analysis and biomarker assessment play a pivotal role in defining
patient outcomes. Traditional histological criteria such as tumor size, lymph node involvement, histo-
logical type and grade, lymphovascular invasion, and immune cell infiltration are significant prog-
nostic indicators. In addition to the hormone receptor, HER2, and—in specific scenarios—BRCA1/2
testing, molecular subtyping through gene expression profiling provides valuable insights to tailor
clinical decision-making. The emergence of “omics” technologies, applicable to both tissue and liquid
biopsy samples, has broadened our arsenal for evaluating the risk of early BC. However, a pressing
need remains for standardized methodologies and integrated pathological models that encompass
multiple analytical dimensions. In this study, we provide a detailed examination of the existing
strategies for early BC risk stratification, intending to serve as a practical guide for histopathologists
and molecular pathologists
Centralization versus decentralization of marketing activities in leading Italian firms
No full textInternational and multinational companies are showing an increasing
interest in developing global strategies, that is, in taking integrated and
globally uniform approaches to their strategy and planning process. There
have been a number of studies discussing the merits of a global versus a
local approach. However, none of these studies have empirically tested the
complex implementation issues of a global marketing strategy, let alone an
integrated global marketing strategy (Sheth,2001; Guerini 2006, 2007).
Therefore a thorough analysis and research of global marketing operations
integration is definitely needed. The framework of this paper is constructed on the basis of multi-disciplinary prior research by the author.
Moreover, integrating marketing with further inter- and intra- functional
activities, on a worldwide scale, involves some understanding of various
issues in international business, including organization theory, trade theory, strategic management, marketing organization and strategy, social sciences, and an understanding of behavioral, relationship and cultural
issues. The first part briefly reviews the main concepts regarding those theories in order to establish a conceptual foundation of the study. It then
outlines the research questions and methodology, and the proposed output. The second part analyzes five Italian companies in order to gain a
sound understanding of how and why Italian companies are implementing
an integrated global marketing approach. The strategy used is a combination of case study research and archival analysis. The third part shows the
main findings of the research and its limitations
Trust breaks down in electronic contexts but can be repaired by some initial face-to-face contact
No full textLos Angele
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