136 research outputs found
Vitamina D e artrite reumatoide
No full textRecentemente si è osservato che la vitamina D svolge un ruolo importante nella regolazione della risposta immune. Molte cellule del sistema immunnitario esprimono i recettori della vitamina D. Studi in vitro e in vivo hanno mostrato che i metabolici della vitamina D modulano la proliferazione dei linfociti T e l’attività delle cellule dendritiche. Inoltre dati epidemiologici mostrano che la carenza di vitamina D si associa ad un aumentato rischio di sviluppare malattie autoimmuni. La carenza di vitamina D è piuttosto frequente tra la popolazione anziana e si associa a sintomi muscoloscheletrici. Nell’ artite reumatoide la sua carenza parrebbe associarsi ad un aumentato rischio di disabilità e ad un aumentata attività di malattia. Abbiamo studiato 1191 pazienti affetti da AR (85% donne) provenienti da 22 Centri reumatologici italiani. Sono stati eseguiti dosaggi centralizzati della 25 OH vitamina D e del PTH, sono stati valutati i parametri di attività di malattia, lo stato funzionale di malattia, il tempo di esposizione al sole. Il 55% dei pazienti non assumevano supplementi di vitamina D, tra questi il 52% avevano livelli vitaminici D 0.000). The patients with the worse indices of disease activity were spending significantly less time at sunshine. The association between disease activity scores or functional sores and 25(OH)D levels remained statistically significant even adjusting 25(OH)D levels for both sun exposure time and BMI. In conclusion, in RA patients disease activity and disability scores are inversely related with 25(OH)D levels. The causality of these associations must be confirmed by longitudinal studies aimed at evaluating the clinical response of disease activity to large vitamin D supplementations
Indicadores de Biodiversidad : Informe preparado por el proyecto INTA PI 038. Evaluaion, monitoreo y manejo de la biodiversidad en sistemas agropecuarios y forestales
No full textSe puede definir a la biodiversidad como “la variabilidad de organismos vivos de cualquier fuente, incluidos, entre otras cosas, los ecosistemas terrestres y marinos y otros ecosistemas acuáticos y los complejos ecológicos de los que forman parte; comprende la diversidad dentro de cada especie, entre las especies y de los ecosistemas.”. La biodiversidad es el sustento, en cada ecosistema, de su funcionamiento. Las funciones ecológicas, como el equilibrio y la resiliencia del sistema; la regulación de los ciclos biogeoquímicos, son a su vez la base de los servicios ecosistémicos. Entre ellos los servicios de provisión, como la producción de alimentos, medicinas, fibras, agua de bebida los de regulación y sostén, como la regulación de los flujos de agua, la purificación del agua y el aire, el hábitat para la fauna; o los servicios culturales, como las experiencias recreativas, espirituales y hasta aspectos de la identidad de los pueblo están ligados a la biodiversidad.Estación Experimental Agropecuaria BarilocheFil: Rusch, Veronica Elena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Recursos Forestales. Grupo Ecología Forestal; ArgentinaFil: Natalia Fracassi. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Delta del Paraná; Argentin
sj-tif-1-tab-10.1177_1759720X221124543 – Supplemental material for Comparable long-term retention rates and effects on bone mineral density of denosumab treatment in patients with osteoporosis with or without autoimmune inflammatory rheumatic diseases: real-life data
No full textSupplemental material, sj-tif-1-tab-10.1177_1759720X221124543 for Comparable long-term retention rates and effects on bone mineral density of denosumab treatment in patients with osteoporosis with or without autoimmune inflammatory rheumatic diseases: real-life data by Angelo Fassio, Davide Gatti, Davide Bertelle, Elena Fracassi, Giulia Zanetti, Ombretta Viapiana, Maurizio Rossini and Giovanni Adami in Therapeutic Advances in Musculoskeletal Disease</p
Calcio e derivati della vitamina D, terapia sostitutiva, calcitonina, fluoruri, bisfosfonati
No full textL’osteoporosi è una patologia multifattoriale; l’approccio medico deve quindi realizzarsi su livelli differenti e su molteplici condizioni di rischio, e prevedere per questo sia provvedimenti non farmacologici che di tipo farmacologico
Osteoporosis Treatment: When to Discontinue and When to Re-start
No full textA number of effective therapies for the treatment of osteoporosis have become available in recent years. However, uncertainty exists regarding their long-term use and effectiveness. Bisphosphonate treatment, unlike hormone replacement, denosumab or teriparatide, is associated with benefits extended even after treatment discontinuation. The extended benefits are most apparent for alendronate (ALN) and zoledronate (ZOL). A drug holiday might be considered in patients at low-moderate risk and who have been fully compliant with treatment, and who have had a response to treatment. In patients at low-moderate risk of fractures the decision to consider a drug holiday should be balanced also with the safety profile of each treatment
Neridronic acid for the treatment of bone metabolic diseases
No full textneridronic acid; bisphosphonate; bone disease
sj-docx-1-tab-10.1177_1759720X221105009 – Supplemental material for Real-life short-term effectiveness of anti-osteoporotic treatments: a longitudinal cohort study
No full textSupplemental material, sj-docx-1-tab-10.1177_1759720X221105009 for Real-life short-term effectiveness of anti-osteoporotic treatments: a longitudinal cohort study by Giovanni Adami, Irene Gavioli, Maurizio Rossini, Ombretta Viapiana, Giovanni Orsolini, Camilla Benini, Eugenia Bertoldo, Elena Fracassi, Davide Gatti and Angelo Fassio in Therapeutic Advances in Musculoskeletal Disease</p
Greyhound e oltre: come la razza può influenzare l'interpretazione dei dati clinico-patologici
No full textSingle Step Plasma Deposition of Platinum-Fluorocarbon Nanocomposite Films as Electrocatalysts of Interest for Micro Fuel Cells Technology
No full textIn this paper, we present a one step plasma based approach for the deposition of Pt-fluorocarbon nanocomposite films as electrocatalysts in hydrogen-based micro fuel cells. Results show that the chemical and morphological structure of the film can be tuned by controlling the power delivered to the plasma, and the gas feed composition. Platinum is included in the film in metallic form and its content can be continuously varied from a few atomic percent to 86%. The metal is embedded in the film as crystalline nanoclusters of size below 10 nm, uniformly distributed across the sample. Film catalytic activity, in terms of hydrogen oxidation reaction, has been tested by cyclovoltammetry and it increases with the Pt loading, with a maximum specific electrochemical surface area of 94cm2 · mg-1, for film deposited on flat glassy carbon
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