900 research outputs found
Soft X-ray spectral variability of AM Herculis
No full textContext.
Polars (AM Herculis binaries) are a prominent class of bright soft X-ray
sources, many of which were discovered with ROSAT.
Aims.
We present a homogenous analysis of all the pointed ROSAT PSPC
observations of polars subdivided into two papers that discuss
the prototype polar AM He
Interview with Afaf Radi and Samha El-Kholy
No full textمقابلة مع المطربة عفاف راضي والمؤرخة الموسيقية المصرية البارزة سمحه الخولي حول رأيهم في الفنان الدارس للموسيقي الغربيه حين يؤدي الأغنية العربية.An interview with singer Afaf Radi and well-known Egyptian musicologist Samha El-Kholy about their opinions on the artist learning Western music while performing Arabic songs
Adipokine profile in growth hormone deficient (GHD) children before and after GH treatment
No full textIndagine conoscitiva sugli interventi organici in corso da parte di istituzioni pediatriche italiane a favore dell'assistenza pediatrica dei paesi in via di sviluppo
No full textPegvisomant-primed GH stimulation test.
No full textObjective Provocative stimulation tests for GH assessment have poor reproducibility and can often elicit false positive results in normal children. The aim of our study was to evaluate the capability of pegvisomant, as an enhancer of GH secretion, in unmasking false-positive results in short children undergoing GH testing.
Design A prospective study was conducted between March 2005 and April 2006.
Patients Twenty-one short children (8 males and 13 females), aged 1.0-14.5 years, with a height of < 2 SD scores below the mean were included in the study.
Methods All subjects underwent an L-DOPA stimulation test with evaluation of GH. At the end of the test, 1 mg/kg of pegvisomant was given subcutaneously and 3 days later an L-DOPA stimulation test was repeated.
Results There was a significant decrease of IGF-I SDS following pegvisomant (-1.75 +/- 0.24 vs. -2.65 +/- 0.23; P < 0.0001) and a significant increase of the GH-peak (6.2 +/- 0.91 vs. 15.3 +/- 2.30 mu g/l; P < 0.0001). Among the 21 patients examined, 18 (85.7%) had an insufficient response (< 10 mu g/l) at the first stimulation. Ten of them (55.5%) showed normal secretion after priming with pegvisomant, while insufficient secretory reserve was confirmed in the remaining eight.
Conclusions Pegvisomant priming before GH stimulation tests can be used to improve the reliability of the diagnostic work up in GH deficiency. Further studies are required, however, to clarify whether this procedure should be recommended in the routine evaluation of GH status
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