22 research outputs found
Mrs. Wiggs of the Cabbage Patch
No full textA national bestseller when first published in 1901, Mrs. Wiggs of the Cabbage Patch endures today as one of the most memorable literary creations by a Kentucky author. This immensely popular novel spawned several movies (with such stars as W.C. Fields and Shirley Temple), countless stage productions, radio shows, and even dolls.
Alice Hegan Rice spins the memorable tale of a family struggling against all odds in the Cabbage Patch, an old Louisville slum “where ramshackle cottages played hop-scotch over the railroad tracks.” This hopeful story follows the Wiggs as they face eviction from their dilapidated house and take in two orphanage fugitives. Out of print for many years, this charming, funny chronicle of hope triumphing over despair is finally available to a new generation of readers.
Alice Hegan Rice (1870–1942) was the author of twenty books, including the autobiography The Inky Way. She lived in Louisville, Kentucky.
The stories of the Wiggs family are both heart-wrenching and hilarious, filled with Southern dialect and philosophy. —Kentucky Living
To miss reading this story is to miss the brightest shade on the palette of Kentucky local color. —Southsider
Endures today as one of the most memorable literary creations by a Kentucky author. —Union Co. (KY) Advocatehttps://uknowledge.uky.edu/upk_creative_writing/1004/thumbnail.jp
Neural basis for priming of pop-out during visual search revealed with fMRI
No full textMalikovic and Nakayama first showed that visual search efficiency can be influenced by priming effects. Even "pop-out" targets (defined by unique color) are judged quicker if they appear at the same location and/or in the same color as on the preceding trial, in an unpredictable sequence. Here, we studied the potential neural correlates of such priming in human visual search using functional magnetic resonance imaging (fMRI). We found that repeating either the location or the color of a singleton target led to repetition suppression of blood oxygen level-dependent (BOLD) activity in brain regions traditionally linked with attentional control, including bilateral intraparietal sulci. This indicates that the attention system of the human brain can be "primed," in apparent analogy to repetition-suppression effects on activity in other neural systems. For repetition of target color but not location, we also found repetition suppression in inferior temporal areas that may be associated with color processing, whereas repetition of target location led to greater reduction of activation in contralateral inferior parietal and frontal areas, relative to color repetition. The frontal eye fields were also implicated, notably when both target properties (color and location) were repeated together, which also led to further BOLD decreases in anterior fusiform cortex not seen when either property was repeated alone. These findings reveal the neural correlates for priming of pop-out search, including commonalities, differences, and interactions between location and color repetition. fMRI repetition-suppression effects may arise in components of the attention network because these settle into a stable 1. attractor state" more readily when the same target property is repeated than when a different attentional state is required
Dickerson and Venable Families (SC 1574)
No full textFinding aid and scans (Click on Additional Files below) for Manuscripts Small Collection 1574. Genealogical charts, news clippings, and photographs of members of the Dickerson and Venable families of Warren County, Kentucky. Also includes a news clipping from the Park City Daily News, 9 January 1947, about author Rosa Praigg Dickerson, who published under the name Violet Woods, and a pre-1911 photo and program from a production of Mrs. Wiggs and the Cabbage Patch performed at Woodburn College
Are Children Getting Enough Sleep? Implications for Parents
No full textSleeping is a child\'s primary activity; by the time an average child goes to school they will have spent more time sleeping than engaging in any other activity, such as playing, eating or interacting socially. Disturbances of sleep (especially sleeplessness) are one of the most frequent child behaviour problems to be reported by parents, affecting about 30% of typically developing children and adolescents. The definition of \'sleeplessness problems\' will be considered noting how, with child sleeplessness, the complainant and the sufferer are frequently not the same person (frequently parents are the former and the children the latter), and that this has implications for how we should define and, where appropriate, attempt to \'treat\' these problems. Parental perceptions and parental sleep patterns, moreover, may be key in understanding how some child sleeplessness problems are conceptualised, how they might impact on the child and family and the mechanisms by which successful intervention for childhood sleeplessness may result in benefits for families. The author suggests that child sleeplessness might be better theoretically conceptualised as comprising two distinct states with different causes and effects. Firstly, a `biologically-defined sleeplessness` characterised by a child having objectively impaired sleep quantity and/or quality, relative to their biological sleep needs. Secondly, a \'socially-defined sleeplessness\' characterised by the child\'s sleep pattern deviating from a desired sleep pattern. Judgements about what constitutes a \'desired\' sleep pattern will be influenced by multiple factors including expectations and culture. Both of these states may exist independently, or co-exist. Both of these states must be considered in order to decide whether or not children are getting enough sleep.Children – Parents – Mothers – Fathers – Sleeplessness -
Mechanisms of top-down facilitation in perception of visual objects studied by fMRI
No full textPrior knowledge regarding the possible identity of an object facilitates its recognition from a degraded visual input, though the underlying mechanisms are unclear. Previous work implicated ventral visual cortex but did not disambiguate whether activity-changes in these regions are causal to or merely reflect an effect of facilitated recognition. We used functional magnetic resonance imaging to study top-down influences on processing of gradually revealed objects, by preceding each object with a name that was congruent or incongruent with the object. Congruently primed objects were recognized earlier than incongruently primed, and this was paralleled by shifts in activation profiles for ventral visual, parietal, and prefrontal cortices. Prior to recognition, defined on a trial-by-trial basis, activity in ventral visual cortex rose gradually but equivalently for congruently and incongruently primed objects. In contrast, prerecognition activity was greater with congruent priming in lateral parietal, retrosplenial, and lateral prefrontal cortices, whereas functional coupling between parietal and ventral visual (and also left lateral prefrontal and parietal) cortices was enhanced in the same context. Thus, when controlling for recognition point and stimulus information, activity in ventral visual cortex mirrors recognition success, independent of condition. Facilitation by top-down cues involves lateral parietal cortex interacting with ventral visual areas, potentially explaining why parietal lesions can lead to deficits in recognizing degraded objects even in the context of top-down knowledge
Pharmacogenetics of ophthalmic topical β-blockers
No full textGlaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure. Genetic variability has been postulated to contribute to interpersonal differences in efficacy and safety of topical β-blockers. This review summarizes clinically significant polymorphisms that have been identified in the β-adrenergic receptors (ADRB1, ADRB2 and ADRB3). The implications of polymorphisms in CYP2D6 are also discussed. Although the candidate-gene approach has facilitated significant progress in our understanding of the genetic basis of glaucoma treatment response, most drug responses involve a large number of genes, each containing multiple polymorphisms. Genome-wide association studies may yield a more comprehensive set of polymorphisms associated with glaucoma outcomes. An understanding of the genetic mechanisms associated with variability in individual responses to topical β-blockers may advance individualized treatment at a lower cost
The efficacy of enzyme replacement therapy in patients with chronic neuronopathic Gaucher’s disease
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Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
No full textEmmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article. This has now been corrected in both the PDF and HTML versions of the Article
Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
No full textEmmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article. This has now been corrected in both the PDF and HTML versions of the Article
Impaired Proteostasis in Obese Skeletal Muscle Relates to Altered Immunoproteasome Activity
No full textObesity-associated inflammation and/or oxidative stress can damage intramuscular proteins and jeopardize muscle integrity. The immunoproteasome (iProt) is vital to remove oxidatively modified proteins, but this function may be compromised with obesity. We sought to elucidate whether diet-induced obesity (DIO) alters intramuscular iProt content and activity in mice to identify a possible mechanism for impaired muscle proteostasis in the obese state. Total proteasome content and activity and estimates of muscle oxidative damage, inflammation, muscle mass and strength were also assessed. Twenty-three male, 5-week-old C57BL/6J mice were fed a high-fat, high-sucrose (HFS, 45% kcal fat, 17% sucrose, n = 12) or low-fat, low-sucrose (LFS, 10% kcal fat, 0% sucrose, n = 11) diet for 12 weeks. Strength was assessed via a weightlifting test. Despite no change in pro-inflammatory cytokines (P > 0.05), oxidative protein damage was elevated within the gastrocnemius (P = 0.036) and tibialis anterior (P = 0.033) muscles of HFS-fed mice. Intramuscular protein damage coincided with reduced iProt and total proteasome activity (PThe presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
