232 research outputs found
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Systemic Loss: A Measure of Financial Stability (in English)
No full textThe literature on modeling defaults in individual financial institutions has expanded dramatically. However, the links between defaults in individual institutions and system-wide crises remain inadequately understood, despite some recent attempts to transpose the existing indicators of the probability of default in individual institutions to the systemic level. The paper argues that any measure of systemic stability should incorporate three elements: probabilities of failure in individual financial institutions, loss given default in financial institutions, and correlation of defaults across institutions. It contains a review of existing measures of financial stability and finds that they generally fall short of this standard. The author demonstrates that looking at the distribution of systemic loss can lead to a clearer differentiation of cases of stability and instability.failures; financial sector; market-based indicators; soundness indicators
Differential patterns in comparative education discourse
No full textThis dissertation study argues that 'policy advice formation', as a discourse development, is a differentiated hybrid resultant from merger between comparative education and policy studies disciplines. Through discourse analysis based on John Creswell's format, this study identifies revisions, restatements and shifts in emphasis of theories, methodological models and challenge topics of comparative education and policy studies. Findings which display the development of policy advice formation' discourse. In conclusion, this study found differential patterns seemingly formed because of collaborative affects of standardization in education science knowledge expressed within discourse
Recommended from our members
Hong Kong: workfare in the world's freest economy
No full textWorkfare was introduced in many countries to suppress welfare dependency and reduce social security expenditures. However, workfare was launched in Hong Kong when there was only a relatively small social security budget and its citizens still strongly adhered to the ideologies of self-reliance. It was found that workfare has performed several functions in Hong Kong. Firstly, it has forced unemployed claimants to give up benefits so that Hong Kong's social security expenditures can be saved. Secondly, workfare had combined with Hong Kong's semi-democratic polity so that extremely stigmatising welfare measures were implemented. Thirdly, it has pushed poor citizens to the labour market without having any protection over wages and working hours. Thus, the combination of workfare and a semi-democratic polity has successfully suppressed Hong Kong's welfare demands and strengthened its self-help spirit. As a result, Hong Kong's minimal social security scheme and its low tax policy have been maintained
Immunotherapy for diabetic amyotrophy.
No full textCochrane database of systematic reviews (Online)6CD006521
Immunotherapy for diabetic amyotrophy
No full text10.1002/14651858.CD006521Cochrane Database of Systematic Reviews2
[[alternative]]Correction: FOXM1 is required for small cell lung cancer tumorigenesis and associated with poor clinical prognosis (Oncogene, (2021), 40, 30, (4847-4858), 10.1038/s41388-021-01895-2)
No full text[[abstract]]In this article, the author name Shih-Chin Cheng was incorrectly written as Shin-Chin Cheng. In the list of affiliations, item 11 was given by mistake, correct is item 10. These authors contributed equally: Sheng-Kai Liang, Chia-Chan Hsu. The original article has been corrected
Ligasure vessel-sealing system or harmonic scalpel versus conventional vessel ligation for thyroidectomy
No full text- …
