481 research outputs found
Predicting the Position of the Hydrogen Atom in the Short Intramolecular Hydrogen Bond of the Hydrogen Maleate Anion from Geometric Correlations
No full textThe position of the hydrogen atom inside the strong and short intramolecular hydrogen bond of the hydrogen maleate anion strongly varies depending on the crystalline environment. Therefore, it has not been possible in the past to accurately determine it using X-ray diffraction data although there are 292 hydrogen maleate crystal structures with different cations in the literature. In this study, a geometric correlation for the accurate prediction of the hydrogen position in the short intramolecular hydrogen bond is presented. The results used to derive the correlation are obtained from low-temperature neutron-diffraction studies on nine different hydrogen maleate salts that span the whole range from perfectly symmetric to highly asymmetric intramolecular hydrogen bonds. Since the only variable in the correlation as derived from the neutron data is the O···O distance, the hydrogen atom position in question can subsequently be predicted using information that is accurately available from routine X-ray data. The procedure is tested using high-resolution low-temperature synchrotron X-ray diffraction structures of the same compounds, before it is applied to X-ray data sets found in the literature in which the hydrogen atom position was not determined accurately or not determined at all, e.g., using a riding model
Supplementary_Material – Supplemental material for Machine Learning Methods Predict Individual Upper-Limb Motor Impairment Following Therapy in Chronic Stroke
No full textSupplemental material, Supplementary_Material for Machine Learning Methods Predict Individual Upper-Limb Motor Impairment Following Therapy in Chronic Stroke by Ceren Tozlu, Dylan Edwards, Aaron Boes, Douglas Labar, K. Zoe Tsagaris, Joshua Silverstein, Heather Pepper Lane, Mert R. Sabuncu, Charles Liu and Amy Kuceyeski in Neurorehabilitation and Neural Repair</p
Sovereign authority and the elaboration of law in the Bible and the ancient Near East
No full textFive Pentateuchal texts (Lev 24:10-23; Num 9:6-14; Num 15:32-36; Num 27:1-11; Num 36:1-12) offer unique visions of the elaboration of law in Israel's formative past. In response to individual legal cases, Yahweh enacts impersonal and general statutes reminiscent of biblical and ancient Near Eastern law collections. From the perspective of comparative law, Dylan R. Johnson proposes a new understanding of these texts as biblical rescripts: a legislative technique that enabled sovereigns to enact general laws on the basis of particular legal cases. Typological parallels drawn from cuneiform and Roman law illustrate the complex ideology informing the content and the form of these five cases. The author explores how latent conceptions of law, justice, and legislative sovereignty shaped these texts, and how the Priestly vision of law interacted with and transformed earlier legal traditions
Understanding the Consumption of Antimicrobial Resistance–Related Content on Social Media: Twitter Analysis
No full textBackground: Antimicrobial resistance (AMR) is one of the most pressing concerns in our society. Today, social media can function as an important channel to disseminate information about AMR. The way in which this information is engaged with depends on a number of factors, including the target audience and the content of the social media post.
Objective: The aim of this study is to better understand how AMR-related content is consumed on the social media platform Twitter and to understand some of the drivers of engagement. This is essential to designing effective public health strategies, raising awareness about antimicrobial stewardship, and enabling academics to effectively promote their research on social media.
Methods: We took advantage of unrestricted access to the metrics associated with the Twitter bot @AntibioticResis, which has over 13,900 followers. This bot posts the latest AMR research in the format of a title and a URL link to the PubMed page for an article. The tweets do not contain other attributes such as author, affiliation, or journal. Therefore, engagement with the tweets is only affected by the words used in the titles. Using negative binomial regression models, we measured the impact of pathogen names in paper titles, academic attention inferred from publication counts, and general attention estimated from Twitter on URL clicks to AMR research papers.
Results: Followers of @AntibioticResis consisted primarily of health care professionals and academic researchers whose interests comprised mainly AMR, infectious diseases, microbiology, and public health. Three World Health Organization (WHO) critical priority pathogens—Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae—were positively associated with URL clicks. Papers with shorter titles tended to have more engagements. We also described some key linguistic characteristics that should be considered when a researcher is trying to maximize engagement with their publication.
Conclusions: Our finding suggests that specific pathogens gain more attention on Twitter than others and that the levels of attention do not necessarily correspond to their status on the WHO priority pathogen list. This suggests that more targeted public health strategies may be needed to raise awareness about AMR among specific pathogens. Analysis of follower data suggests that in the busy schedules of health care professionals, social media offers a fast and accessible gateway to staying abreast of the latest developments in this field
Functional analysis of sorsby's fundus dystrophy mutant TIMP-3
No full textBibliography: p. 216-24
The expression of tissue inhibitor of matrix metalloproteinase-2 in activated T cells: Role in Tcell growth modulation
No full textBibliography: p. 167-21
Tissue inhibitors of metalloproteinases in human malignant gliomas
No full textBibliography: p. 119-12
The potential role of the proto-oncogene c-myc in the regulation of the matrix metalloproteinase gelatinase B
No full textBibliography: p. 127-141
Recepção do texto bíblico em Man Gave Name To All The Animals de Bob Dylan
No full textThe American singer, songwriter and author Bob Dylan (b. 1941) has been for more than half a century one of the most distinguished and influential figures in the scene of world pop culture. This articles intends analyse how the biblical text of Genesis 2.19b-20a (“the man gave names to every type of animals”) in his song Man gave to all the animals, of 1979. Therefore, the article will have this structure: (1) presentation of some aspects of Bob Dylan’s life and work; (2) an analysis of lyrics and music of the mentioned song; (3) presentation of rereadings of the song in the scene of world pop culture (Brazil included) and (4) critical remarks about the reception of the biblical text in the aforementioned song. Thus, the article intends to present a “trialogue” between literature, music, theology and the religious studies.Bob Dylan (n. 1941), cantor, compositor e escritor estadunidense há mais de meio século tem sido uma das figuras mais destacadas e influentes no cenário da cultura pop mundial. O presente artigo tem objetivo de analisar como o texto bíblico de Gênesis 2.19b-20a (“o nome que o homem desse a todos os seres viventes, esse seria o nome deles. Deu nome o homem a todos os animais domésticos, às aves dos céus e a todos os animais selváticos”) em sua canção Man gave to all the animals, de 1979. Para tanto, o artigo terá a seguinte estrutura: (1) apresentação de aspectos da vida e obra de Bob Dylan; (2) análise da letra e da música da canção; (3) apresentação da releituras da canção no cenário da cultura pop mundial (inclusive no Brasil) e (4) considerações críticas sobre a recepção do texto bíblico na mencionada canção. Desta maneira o artigo pretende apresentar um “triálogo” crítico entre literatura, música e a teologia e os estudos de religião
Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo
No full textCNS tuberculosis (CNS-TB) is the most deadly form of tuberculous disease accounting for 10% of clinical cases. CNS-TB is characterized by extensive tissue destruction, in which matrix metalloproteinases (MMPs) may play a critical role. We investigated the hypothesis that Mycobacterium tuberculosis activates monocyte-astrocyte networks increasing the activity of key MMPs. We examined the expression of all human MMPs and the tissue inhibitors of metalloproteinases (TIMPs) in human astrocytes stimulated by conditioned medium from M. tuberculosis-infected monocytes (CoMTB). Real-time RT-PCR showed that gene expression of MMP-1, -2, -3, -7, and -9 was increased (p < 0.05). MMP-9 secretion was significantly up-regulated at 24 h and increased over 120 h (p < 0.01). MMP-1, -3, and -7 secretion was not detected. Secretion of MMP-2 was constitutive and unaffected by CoMTB. Astrocyte gene expression and secretion of TIMP-1 was not affected by CoMTB although TIMP-2 secretion increased 3-fold at 120 h. Immunohistochemical analysis of human brain biopsies confirmed that astrocyte MMP-9 secretion is a predominant feature in CNS-TB in vivo. Dexamethasone inhibited astrocyte MMP-9, but not TIMP-1/2 secretion in response to CoMTB. CoMTB stimulated the nuclear translocation of NF-kappaB, inducing a 6-fold increase in nuclear p65 and a 2-fold increase in nuclear p50. This was associated with degradation of IkappaBalpha and beta within 30 min, persisting for 24 h. In summary, networks active between monocytes and astrocytes regulate MMP-9 activity in tuberculosis and astrocytes are a major source of MMP-9 in CNS-TB. Astrocytes may contribute to a matrix degrading environment within the CNS and subsequent morbidity and mortality
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