643 research outputs found
P.J. Thumerelle (et alii) : Atlas du Pas-de-Calais. Lyon, Edit. Horvath, 1993
No full textBruyelle Pierre. P.J. Thumerelle (et alii) : Atlas du Pas-de-Calais. Lyon, Edit. Horvath, 1993. In: Hommes et Terres du Nord, 1993/3-4. Picardie 1993. p. 150
P.J. Thumerelle (et alii) : Atlas du Pas-de-Calais. Lyon, Edit. Horvath, 1993
No full textBruyelle Pierre. P.J. Thumerelle (et alii) : Atlas du Pas-de-Calais. Lyon, Edit. Horvath, 1993. In: Hommes et Terres du Nord, 1993/3-4. Picardie 1993. p. 150
Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity
No full textHepatic involvement is commonly observed in arenavirus infections, but the viral determinants of liver disease are only partially understood. Here we exploited newly developed reverse-genetic techniques with Lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, to address specifically the contribution of the viral glycoprotein (GP) to liver pathogenicity. It is well established that strain WE, but not ARM, causes hepatitis in mice. We found that this property correlated with the superior capacity of WE to propagate in cultured macrophages and hepatocyte-derived cells. In mice, the ability to establish prolonged viraemia allowed the virus to propagate from initially infected Kupffer cells in the liver to neighbouring hepatocytes that underwent apoptosis. Reverse-genetic replacement of the GP in strain ARM with WE-GP resulted in only a very modest increase in liver pathogenicity, if any. Yet, an ARM-derived variant virus with a mutated polymerase gene caused severe liver disease when engineered to display WE-GP but considerably less when expressing ARM-GP. This reverse-genetic approach to an animal model of arenaviral hepatitis reveals a previously underestimated contributory role of the GP that alone is, however, insufficient to cause disease
"Amplifying unheard voices in Digital Humanities: an OpenMethods edit-a-thon" (Slides)
No full textSlides used for the OpenMethods edit-a-thon during DH2023 Graz, 10.07.2023
Facilitators: Alíz Horvath, Christopher Nunn, Ulrike Wuttke.
Tóth-Czifra, Erzsébet, Wuttke, Ulrike, Horváth, Alíz, Nunn, Christopher: “Amplifying unheard voices in Digital Humanities: an OpenMethods edit-a-thon”, in: Baillot, Anne, Tasovac, Toma, Scholger, Walter, & Vogeler, Georg. (2023, July 1). Digital Humanities 2023: Book of Abstracts. Digital Humanities 2023. Collaboration as Opportunity. (DH2023), Graz, Austria, p. 26-27, https://doi.org/10.5281/zenodo.7961822OpenMethods is sustained by DARIAH-EU
Optimum currency area theory: A selective review
No full textThe first part of this paper is a review of significant papers in the vast literature on optimum currency area (OCA) theory. The author focuses on the main classical contributions, then considers modern treatment of OCA theory. The second part considers empirical literature on the types of geographical areas that might constitute optimum currency areas, particularly with respect to asymmetry and symmetry of shocks.
Attenuated lymphocytic choriomeningitis virus: altered parameters of virus-host interactions in the CNS
No full textOptimum currency area theory: A selective review
No full textThe first part of this paper is a review of significant papers in the vast literature on optimum currency area (OCA) theory. The author focuses on the main classical contributions, then considers modern treatment of OCA theory. The second part considers empirical literature on the types of geographical areas that might constitute optimum currency areas, particularly with respect to asymmetry and symmetry of shocks.
T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner
No full textViral infection of the central nervous system can lead to disability and death. Yet the majority of viral infections with central nervous system involvement resolve with only mild clinical manifestations, if any. This is generally attributed to efficient elimination of the infection from the brain coverings, i.e. the meninges, ependyma and chorioplexus, which are the primary targets of haematogeneous viral spread. How the immune system is able to purge these structures from viral infection with only minimal detrimental effects is still poorly understood. In the present work we studied how an attenuated lymphocytic choriomeningitis virus can be cleared from the central nervous system in the absence of overt disease. We show that elimination of the virus from brain ependyma, but not from brain parenchyma, could be achieved by a T cell-dependent mechanism operating independently of major histocompatibility class I antigens and perforin. Considering that cytotoxic T lymphocyte-mediated cytotoxicity is a leading cause of viral immunopathology and tissue damage, our findings may explain why the most common viral intruders of the central nervous system rarely represent a serious threat to our healt
Introduction: in honour of Adalgisa Giorgio
No full textThis is the author accepted manuscript. The final version is available from Routledge via the DOI in this recordIntroduction to: Female filiations: a festschrift for Adalgisa Giorgio Romance Studies. A special issue edited by Dr Christina Horvath and Dr Eliana Maestr
Conceptualization of a real-time information processing platform for context-aware informing cyber-physical systems
No full textInforming cyber-physical systems (I-CPSs) are designed to accomplish sensing, reasoning and informing activities in dynamic context. In order tosimplify and accelerate the design and implementation process of multiple context-aware ICPSs, we are developing an information sensing,computing and actuating (SCA) platform that can be used as a central module of these systems. This paper presents the concept of a SCA platform. Thefunctionality of the platform includes development of context-dependent strategies to adapt the sensing, reasoning and informing behaviors of the platform to various dynamic contexts. There are four constituents of the platform: (1) a generic kernel, (2) built-in elements, (3) add-on components, and (4) system interfaces. The paper also discusses both the internal and external integration mechanism of the SCA platform, which can be customized according to the needs of specific I-CPS applications by extending the generic kernel with various functional built-in elements and add-on components. The feasibility andapplicability of the platform have been tested through a case study: an indoor fire evacuation guiding system. The proposed platform provides a useful package of functionalities, alleviates the burden of developers, and speeds up the development of applications specific context-aware I-CPS.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work publicCyber-Physical System
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