58 research outputs found
Microdissecção de fibras do nervo genito-femural do rato albino. Análise em condições normais e na intoxicação crônica por diclorodifeniltriclo-roetano (DDT)
Get PDFOrientador: Lineu Cesar WerneckDissertação (mestrado) - Universidade Federal do Paraná. Curso de Pós-Graduação em Medicina InternaSem resumo e abstrac
Intoxicaçoes por inseticidas: microdissecção de nervos e histoquimica de musculos em 10 casos
No full textÉ relatado o estudo de nervo sural e músculos em 10 pacientes com intoxicações crônicas por inseticidas organoclorados e organofosforados, sendo utilizadas técnicas de microdissecção de nervos e histoquímica de músculos. Foram estudados os nervos surais de 9 pacientes por microdissecção, tendo sido encontrado anormalidades em todos, predominando a presença de fibras dos tipos C, D e grande quantidade de fibras G, conforme a classificação de Dyck; o nervo do décimo paciente apresentava-se totalmente desmielinizado. Em 8 casos foram estudados músculos com inclusão em parafina e por histoquímica, sendo encontrada denervação em seis; os restantes eram músculos normais. Os autores concluem que o processo atua predominantemente nos axônios, provocando degeneração axonal distal, com fenômeno de "dying back"
Meningite por linfoma primitivo do sistema nervoso central: relato de um caso
Get PDFÉ relatado o caso de uma paciente com 17 anos de idade que apresentou uma síndrome meningítica sem etiologia definida. Recebeu tratamento para meningite purulenta, tuberculosa e fúngica. Na evolução foram descobertas células neoplásicas no líquido cefalorraqueano e, apesar de toda a investigação, não foi possível identificar a localização do tumor primário. No exame postmortem foi encontrada neoplasia de dimensões reduzidas no assoalho do quarto ventrículo, caracterizada histologicamente como linfoma primitivo do sistema nervoso central. Existia difusão de células neoplásicas às meninges e ao parênquima nervoso, penetrando pelos espaços de Virchow-Robin. São apresentados os dados laboratoriais, anatômicos e analisada a patogenia das meningites neoplásicas (carcinomatosas) bem como dos linfomas primitivos do sistema nervoso central
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
No full textABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A. Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals
Professor Abraham Akerman
Get PDFThe authors present a historical review of the contribution of Professor Abraham Akerman to Brazilian neurology, including the famous sign known as “the Alajouanine-Akerman unstable ataxic hand”
Evaluation of the expression of matrix metalloproteinase 9 and neutrophil gelatinase associated lipocalin in serum, urine and tumoral tissues of female dogs suffering from mammary gland tumors
Get PDFIn human medicine, it has been shown recently that the level of expression of matrix metalloproteinase-9 (MMP-9) and neutrophil gelatinase-associated lipocalin (NGAL) in serum, urine, and breast tissue were significantly increased in patients with breast cancer and correlated to several prognostic factors. In the first part, the author presents the MMP-9 and NGAL as a synthesis of current knowledge on their ability to serve as biomarkers of breast cancer in women. In the second, the author presents the production of canine MMP9 and NGAL recombinant proteins, the production of polyclonal antibodies, and their use in various techniques (ELISA, western blot, immunohistochemistry) to assess the level of expression of these proteins in the blood, urine and breast tissue of dogs suffering from mammary gland tumors and demonstrate a positive correlation between these proteins and the presence of a tumor disease of the mammary gland
Is the patent foramen ovale closure the best option?
Get PDFPatent foramen ovale (PFO) closure is indicated in some cases to protect patients against embolic events. The aim of this study was to certify that the method of PFO closure to prevent microemboli (MES) is reliable, using contrast enhanced transcranial Doppler (cTCD) as a diagnostic and follow-up tool. METHODS: cTCD was performed before and after PFO closure in 20 patients. Results obtained a minimum of 12 months after the procedure were analyzed in this study. RESULTS: After the procedure, 14 patients (82%) showed no microemboli in cTCD at rest, but after provocative Valsalva maneuver (VM) microembolic phenomenon were still detected in 14 (70%): 7 (35%) <10 MES, 3 (15%) 10-20 MES and 4 (20%) had more than 20 MES ("curtain"). Only six of the total patients presented no MES in both resting and VM. CONCLUSION: These results showed a large percentage of patients with MES detection in a bubble study with transcranial Doppler more than one year after the procedure of PFO closure, showing right-to-left residual shunting. Despite the small number of patients, this study provides important data about this therapeutic decision
The influence between migraine preven drugs and sumatriptan succinate on motor activity
Get PDFBackground and aim
The motor effect of sumatriptan succinate (SS) and whether or not it is associatedwith different classes of migraine preventive drugs has yet to be studied. We aimed to analyze such drugs\u27 influence on animal motor activity, verifying their effect when used alone or in combination.
Methods
Male Norvegicus rats (n=98) were treated with routinely prescribed migraine preventive drugs and divided into five groups: isotonic saline solution (ISS, control), propranolol, topiramate, flunarizine, and amitriptyline. After five days of daily treatment, the animals received acute treatment with either ISS or Sumatriptan succinate (SS). The drug\u27s influence on motor function behavior was assessed with the rotarod and open field tests.
Results
Propranolol and flunarizine interfered with the motor activity (p=0.006 and 0.002, respectively). SS did not cause motor changes when administered alone. However the SS combined with amitriptyline increased the number of rearings (p=0,045) and reduced the immobility time (p=0.041).
Conclusions
SS exerted no motor effect, although flunarizine and propranolol could produced motor interference
Study of excited <tex>\Lambda_{b}^{0}</tex> in proton-proton collisions at 1as=13TeV
No full textAbstract: A study of excited Lambda(0)(b) baryons is reported, based on a data sample collected in 2016-2018 with the CMS detector at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of up to 140fb(-1). The existence of four excited Lambda(0)(b) states: Lambda(0)(b) (5912)(0), Lambda(0)(b) (5920)(0), Lambda(0)(b) (6146)(0), and Lambda(0)(b) (6152)(0) in the Lambda(0)(b)pi(+)pi(-) mass spectrum is confirmed, and their masses are measured. The Lambda(0)(b)pi(+)pi(-) mass distribution exhibits a broad excess of events in the region of 6040-6100 MeV, whose origin cannot be discerned with the present data. (C) 2020 The Author(s). Published by Elsevier B.V
Evidence for light-by-light scattering and searches for axion-like particles in ultraperipheral PbPb collisions at <tex>\sqrt{s_{NN}}$</tex>=5.02 TeV
No full textAbstract: Evidence for the light-by-light scattering process, gamma gamma -> gamma gamma, in ultraperipheral PbPb collisions at a centre-of-mass energy per nucleon pair of 5.02 TeV is reported. The analysis is conducted using a data sample corresponding to an integrated luminosity of 390 mu b(-1) recorded by the CMS experiment at the LHC. Light-by-light scattering processes are selected in events with two photons exclusively produced, each with transverse energy E-T(gamma) > 2 GeV, pseudorapidity vertical bar eta(gamma)vertical bar 5 GeV, diphoton transverse momentum p(T)(gamma gamma) gamma gamma) = 120 +/- 46(stat) +/- 28(syst) +/- 12(theo) nb, is consistent with the standard model prediction. The m(gamma gamma) distribution is used to set new exclusion limits on the production of pseudoscalar axion-like particles, via the gamma gamma -> a -> gamma gamma process, in the mass range m(a) = 5-90 GeV. (C) 2019 The Author(s). Published by Elsevier B.V
- …
