60 research outputs found
Cage dorée : étude de concert pour piano (Ed. simplifiée (Album du Ménestrel)) / par Ferdinand de Croze ; [ill. par] A. Barbizet,...
No full textTitre uniforme : Croze, Ferdinand de (1827-1902). Compositeur. [Cage dorée. Piano]Piano, Musique de -- +* 1800......- 1899......+:19e siècle:Études (piano) -- +* 1800......- 1899......+:19e siècle
Differential Gene Expression and Translational Approaches to Identify Biomarkers of Interferon Beta Activity in Multiple Sclerosis
No full textEffects of interferons α/β on the proliferation of human micro- and macrovascular endothelial cells
No full textSynthetic interferons (IFNs) are used in the treatment of several types of cancer. In addition to an antitumor effect, IFNs show antiangiogenic activity. The aim of this study was to investigate the effects of IFN-α and IFN-β on human micro- and macrovascular endothelial cells in vitro [human micro vascular lung endothelial cells (HMVEC-L) and human umbilical cord endothelial cells (HUVEC)]. By immunohistochemical staining and quantitative reverse transcriptase (RT)-polymerase chain reaction, we studied expression of type I IFN receptors. We evaluated the effects of IFN-α and IFN-β on the proliferation (DNA content), apoptosis (DNA fragmentation by enzyme-linked immunosorbent assay), and cell cycle distribution (flow-cytometric analysis) of endothelial cells. HUVEC and HMVEC-L cells show comparable expression level of the distinct IFN receptor subtypes. Proliferation of HMVEC-L and HUVEC was inhibited by IFN-β (the half maximal inhibitory concentration [IC(50)] = 60 and 90 IU/mL, respectively), but not by IFN-α at a dose up to 1,000 IU/mL. An interesting and unexpected observation was an inhibition of apoptosis by IFN-β. After 72 h of treatment with IFN-β. Cell cycle inhibition occurs in late S-phase in both cell lines. In conclusion, only IFN-β, not IFN-α (10-1,000 IU/mL), has an inhibitory activity on endothelial cell proliferation. Surprisingly, apoptosis was decreased by IFN treatment, whereas inhibition of proliferation is caused by cell cycle arrest in late S-phas
The unknown East Slavic handwritten dictionary from the beginning of the 18th century ("Lexicon slavo-rutenicum")
No full textThe article deals with the handwritten dictionary from the first part of the 18th century, which is kept in the department of manuscripts in the Jagiellonian Library (Ms. Slav. Qu.28 Lexicon slavo-rutenicum). To some extent its title is erroneous. Actually it is a trilingual dictionary-East Slavic-Latin-German, that is not finished as it has been compiled only till the end of letter „o”. It consists of 746 pages of quarto format. S. Stroyev recognized that the author of the dictionary is Mathurina Veyssière de La Croze (1661–1739), the French orientalist and polyglot, who worked in the Royal Library of Berlin
IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro
No full textIFN-alpha controls hormone secretion and symptoms in human gastroenteropancreatic neuroendocrine tumors (GEP-NET) but it rarely induces a measurable tumor size reduction. The effect of other type I IFNs, e.g., IFN-beta, has not been evaluated. We compared the antitumor effects of IFN-alpha and IFN-beta in BON cells, a functioning human GEP-NET cell line. As determined by quantitative reverse transcription-PCR analysis and immunocytochemistry, BON cells expressed the active type I IFN receptor mRNA and protein (IFNAR-1 and IFNAR-2c subunits). After 3 and 6 days of treatment, IFN-beta significantly inhibited BON cell growth in a time- and dose-dependent manner. IC50 and maximal inhibitory effect on day 6 were 8 IU/mL and 98%, respectively. In contrast, the effect of IFN-alpha resulted significantly in a less potent effect (IC50: 44 IU/mL, maximal inhibition: 26%). IFN-alpha induced only cell cycle arrest, with an accumulation of the cells in S phase. IFN-beta, apart from a more potent delay in S-G2-M phase transit of the cell cycle, also induced a strong stimulation of apoptosis, evaluated by flow cytometry (Annexin V and 7-AAD) and measurement of the DNA fragmentation. Besides, only IFN-beta severely suppressed chromogranin A levels in the medium from BON cells after 6 days of treatment. In conclusion, IFN-beta is much more potent, compared with IFN-alpha, in its inhibitory effect on GEP-NET cell proliferation in vitro through the induction of apoptosis and cell cycle arrest. Further studies are required to establish whether IFN-beta has comparable potent tumor growth inhibitory effects in vivo
Persistency of Neutralizing Anti-Interferon-β Antibodies in Patients with Multiple Sclerosis Treated with Subcutaneous Interferon-β Depends on Antibody Titers, IgG Subclasses, and Affinity Maturation
No full textComments on the lexis of an early 18th c. manuscript East Slavic dictionary
No full textThe paper discusses a little known manuscript dictionary dating from the beginning of the 18th c. that is stored in the manuscript division of the Jagiellonian Library (Ms.Slav. Qu. 28 Lexicon slavo-rutenicum). In actual fact we are dealing with a trilingual (East) Slavic-Latin-German dictionary, which is unfinished (barely reaching the end of letter "o"), and consists of 746 pages in quarto format. The author is thought to be French polyglot and orientalist, Mathurin Veyssière de La Croze. The primary objective of the paper is to discuss the typological-etymological and functional-stylistic typology of the East Slavic vocabulary included in the analysed lexicon. A preliminary overview of the Slavic lexis in the Slavic-Ruthenian Lexicon suggests that the dictionary of the past is worth publishing, so it would become available to a broader group studying the history of East Slavic languages
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