1,065 research outputs found

    C.B. Biezeno (March 2, 1888 - September 5, 1975)

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    Obituary of prof. C.B. Biezeno, written by his former PhD candidate and his later colleague prof. W.T. Koiter.Mechanical, Maritime and Materials Engineerin

    Rede uitgesproken op 17 september 1956 ter gelegenheid van de erepromotie van Dr. Th. von Karman door de promotor Dr. C.B. Biezeno

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    Rede uitgesproken door prof. C.B. Biezeno ter gelegenheid van de erepromotie aan de TH Delft van dr. Theodore von Karman.Precision and Microsystems EngineeringMechanical, Maritime and Materials Engineerin

    Biezeno en de mechanica - Herdenkingsdag 14 mei 1976.

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    Presentations at a symposium commemorating the death of prof.dr.ir. C.B. Biezeno on 5 September 1975. Presentations by prof. A. van der Neut, prof. R.G. Boiten, prof. W.T. Koiter, prof. J.P. den Hartog, and prof. J.F. Besseling.Mechanical, Maritime and Materials Engineerin

    Telmatoscopus Eaton 1904

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    Telmatoscopus Eaton, 1904 brevicolis Bravo & Souza, 2008: 66, Figs 1 –10 Paratypes: 5 ♂♂, BRAZIL, Pará: Santarém, (“ Est. do Aeroporto Km 13, Comunidade Santa Maria, Chácara N. Sra. Nazaré, Mata Alterada ”), 25.xi.1998, R.F., R.D.N. & F. L.S. leg. capixaba Bravo, Santos & Ferreira, 2011: 35, Figs 1 –8 Holotype: ♂, BRAZIL, Espírito Santo: Barra de São Francisco, (“ Povoado de Vargem Alegre ”), 20.x.2009, Santos, C.B. leg. Paratypes: 24 ♂♂, same locality, date and collector as holotype (MZFS); 1 ♂, BRAZIL, Espírito Santo: Pancas, (“Córrego Ubá, CDC trap ”), 10.ii.2009, Santos, C.B. leg. micropilosus Bravo, Santos & Ferreira, 2011: 37, Figs 9–12 Holotype: ♂, BRAZIL, Espírito Santo: Cariacica, (“Represa Duas Bocas”), 07.x.2005, Santos, C.B. leg.Published as part of Ferreira, André Da Silva, Araújo, Maíra Xavier, Vilarinho, Naiara Thaís, Silva-Neto, Alberto Moreira Da & Bravo, Freddy, 2020, Catalogue of type specimens of Insecta (Arthropoda: Hexapoda) deposited in the entomological collection of the Museum of Zoology of Universidade Estadual de Feira de Santana, Brazil, pp. 501-546 in Zootaxa 4728 (4) on page 522, DOI: 10.11646/zootaxa.4728.4.10, http://zenodo.org/record/362654

    Afscheidscollege van Prof. Dr Ir C.B. Biezeno

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    Mechanical, Maritime and Materials Engineerin

    John and Pete Johson with C.B. Olson

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    Photograph - Three men holding up furs with numerous furs hanging on a fence in the background, Soto Landing, Alberta. A note on back reads: John and Pete Johnson and C.B. Olson nearly cleaned a pack of wolves south side of Marten Mountain at Wasp Cree

    A desirable future for technology risk management

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    This paper outlines a scenario for the future of Technology Risk Management which the author suggests is internally consistent, linked to current practice, achievable, and desirable. It is a personal view which reflects the concerns and goals of the author. It is offered as a basis for discussion with others of the goals we might seek jointly to facilitate effective progress

    Clinical and functional studies of autoimmune disorders of neuromuscular transmission

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    Inherited and acquired disorders of the neuromuscular junction are an important cause of muscle weakness and fatigability. In this thesis I focus on the autoimmune disorders of neuromuscular transmission. Myasthenia Gravis (MG) is the most common of these diseases and is typically caused by antibodies against the post-synaptic acetylcholine receptor. Lambert Eaton Myasthenic Syndrome (LEMS) is a pre-synaptic disorder typically caused by antibodies against voltage gated calcium channels (VGCC). With regard to LEMS, my main aim was to gain a more complete understanding of the pathomechanisms of the disease. To date, the direct effect of LEMS IgG on presynaptic neurotransmitter release had not been investigated in detail. I examined how LEMS IgG affects neurotransmitter release by imaging action potential dependent vesicle exocytosis using a fluorescent dye. I found that LEMS IgG significantly inhibited the rate of synaptic vesicle release but this effect was lost in synapses from a Cacna1a knockout mouse. These data provide direct evidence that LEMS is caused by impaired neurotransmitter release due to an effect on P/Q-type VGCCs. With regard to MG, I studied the long-term outcome of patients with thymomatous and non-thymomatous MG after thymectomy and found that in general the outcome was favourable in the majority of patients with 34% of patients achieving complete stable remission. I also reviewed the long-term outcome of patients after a severe exacerbation of MG requiring ITU admission. Despite the significant mortality associated with severe exacerbations of MG, it was found that specialised neuro-intensive care was associated with a good long-term prognosis in the majority of patients. There were no significant differences in outcome in those with early or late onset MG. Overall the data presented in this thesis provide new insights into the pathomechanisms of LEMS IgG and provide new information regarding the long-term outcome of patients with MG
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