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Valutazione prospettica di un protocollo di preparazione meccanica e di antibioticoterapia peroperatoria nella chirurgia del grosso intestino
No full text
Chromosome 5 allele loss in human gastric, ampullary and pancreatic carcinomas
No full textChromosome 5 allele loss is a genetic alteration occurring during the multistep
progression of colon carcinogenesis. To determine whether a similar genetic
alteration occurs in other gastrointestinal malignancies, the authors have
analyzed DNA extracted from freshly frozen normal and neoplastic tissue from
nineteen patients who underwent radical resections for gastric, ampullary and
pancreatic adenocarcinomas at the University of Chicago. Loss of heterozygosity
for alleles on the long arm of chromosome 5 was detected in tumor DNA compared to
normal tissue DNA from the same patient using restriction fragment length
polymorphisms (RFLPs). Eleven patients were informative using the restriction
endonuclease TaqI to generate RFLPs for chromosome 5 probes C11 P11 and pTP5E.
Loss of heterozygosity was found in one of eight informative gastric carcinomas
(12.5%) and in one of two informative ampullary carcinomas. The only informative
pancreatic adenocarcinoma was heterozygous. It is concluded that chromosome 5
allele loss occurs in a variety of gastrointestinal malignancies and suggest that
common genetic origins may underlie these different tumors
Ruolo dell’endoscopia operativa nel follow-up del carcinoma colo-rettale.
No full text(Poligrafica Moderna, Padova
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