1,720,970 research outputs found
Preparation and Characterization of Retinoic Acidic Loaded Nanoparticles for Cancer Therapy
No full textPreparation and Characterization of Retinoic Acidic Loaded Nanoparticles for Cancer Therap
Micro/nanostructured polymeric systems for biomedical and pharmaceutical applications
No full textThis review provides an outline of the polymeric micro/nanostructured advanced systems that are suited for the controlled and targeted administration of, specifically, nonconventional drugs. The contribution of new trends in drug-delivery technology is focused on two major parts, dealing with brief surveys of: the biodegradable/bioerodible polymeric systems used in the formulation of micro/nanoparticles and techniques used in the preparation of micro/nanoparticles for their biomedical application in cancer treatment specifically, in inflammation pathologies, as oxygen carriers (blood substitutes) and in tissue-engineering practice. A small discussion of the future perspectives of the described systems is also given
Bioerodible polymeric nanoconstructs for the administration of hydrophobic bioactive agents in tissue engineering
No full textA Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles
No full texthe goal of present work was to investigate the use of bioerodible polymeric nanoparticles as carriers of retinoic acid (RA), which is known to induce differentiation of several cell lines into neurons. A novel method, named "Colloidal-Coating", has been developed for the preparation of nanoparticles based on a copolymer of maleic anhydride and butyl vinyl ether (VAM41) loaded with RA. Nanoparticles with an average diameter size of 70 nm and good morphology were prepared. The activity of the encapsulated RA was evaluated on SK-N-SH human neuroblastoma cells, which are known to undergo inhibition of proliferation and neuronal differentiation upon treatment with RA. The activity of RA was not affected by the encapsulation and purification processes
Polymeric Nanoparticles for Targeted Delivery of Bioactive Agents and Drugs
No full textPolymeric Nanoparticles for Targeted Delivery of Bioactive Agents and Drug
Polymeric Drug Delivery System.
No full textAs a part of our continuing activity, ongoing over the years at BIOLab of the University of Pisa, on the preparation and characterization of nanostructured polymeric devices (nanoparticles & nanofibres) for targeted administration of drugs and bioactive agents, the present contribution is aimed at providing information on the best suited procedures for the formulation of nanocarriers of biomedical and healthcare interest.
Examples of polymeric nanoparticles formulation for the controlled, targeted release of antineoplastic drugs and bioactive agents selected for the treatment of skin diseases (psoriasis and dermatitis), are reported.
It is essentially based on the follow-ups of formerly EC-funded projects, that that will contribute to the implementation of the ongoing EC project “NANOTHER” CP-IP 213631-2 and “SKINTREAT” CP-TP 213202-
Procedimento e Dispositivo di Elettrofilatura per la Produzione di Nano/Microfibre Polimeriche Unidirezionate
No full textProcedimento e Dispositivo di Produzione di Strutture Tubolari in Materiali Polimerici Termoplastici
No full textNovel electrospun polyurethane/gelatin composite meshes for vascular grafts
No full textNovel polymeric micro-nanostructure meshes as blood vessels substitute have been developed and investigated as a potential solution to the lack of functional synthetic small diameter vascular prosthesis. A commercial elastomeric polyurethane (Tecoflex(A (R)) EG-80A) and a natural biopolymer (gelatin) were successfully co-electrospun from different spinnerets on a rotating mandrel to obtain composite meshes benefiting from the mechanical characteristics of the polyurethane and the natural biopolymer cytocompatibility. Morphological analysis showed a uniform integration of micrometric (Tecoflex(A (R))) and nanometric (gelatin) fibers. Exposure of the composite meshes to vapors of aqueous glutaraldehyde solution was carried out, to stabilize the gelatin fibers in an aqueous environment. Uniaxial tensile testing in wet conditions demonstrated that the analyzed Tecoflex(A (R))-Gelatin specimens possessed higher extensibility and lower elastic modulus than conventional synthetic grafts, providing a closer matching to native vessels. Biological evaluation highlighted that, as compared with meshes spun from Tecoflex(A (R)) alone, the electrospun composite constructs enhanced endothelial cells adhesion and proliferation, both in terms of cell number and morphology. Results suggest that composite Tecoflex(A (R))-Gelatin meshes could be promising alternatives to conventional vascular grafts, deserving of further studies on both their mechanical behaviour and smooth muscle cell compatibility
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