1,721,058 research outputs found
Ytterbium triflate catalyzed one-pot oxidation intramolecular Cannizzaro reaction of aryl methyl ketones
No full textSynthesis of a novel prodrug of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid for colon delivery.
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Natural Propenoic Acid Derivative Activates Peroxisome Proliferator-Activated Receptor β/δ (PPAR β/δ)
No full textYtterbium Triflate Promoted Coupling Reaction Between Aryl Alkynes and Aldehydes
No full textA simple and efficient solvent-free coupling reaction affording regioselectively trans-α,β-enones from aryl alkynes and aldehydes catalysed by Yb(OTf)3 hydrate is described
Waste Waters of Milk and Cheese Processing as an Efficient Promoter for the Synthesis of 1,8-dioxo-octahydroxanthones
No full textWaste waters of agricultural and industrial processing have been recently employed to effectively promote numerous “classic” and innovative processes of synthetic organic chemistry. Such a green chemical approach allowed to bypass the use of toxic, polluting, and hazardous chemicals and in the meantime led to an increase of the commercial values of such byproducts. Xanthenes are a group of natural and semi-synthetic compounds with great pharmacological potentialities, also used for several other applications. In this paper we described a new and improved methodology for the synthesis of the title compounds using waste waters of milk and cheese processing as a solvent. 1,8-Dioxo-octahydroxanthenes were obtained in very good yields (94 – 98 %) from differently substituted aromatic aldehydes and dimedone as substrates. Although several reports about the synthesis of 1,8-dioxo-octahydroxanthenes have been published in recent years, this is the first report about the use of waste waters of agricultural and industrial processing to this aim. The findings depicted herein underline once again the great usefulness of agricultural and food industry byproducts to perform green chemical processes
HPLC analysis of 4'-geranyloxyferulic and boropinic acids in grapefruits of different geographical origin
No full text4 '-Geranyloxyferulic [3-(4 '-geranyloxy-3 '-methoxyphenyl)-2-trans-propenoic acid] (GOFA) and boropinic acid have been discovered as valuable phytochemicals exerting notable pharmacological effects as cancer chemopreventive and anti-Helicobacter pylori agents, respectively. A reverse-phase HPLC-UV/ Vis method for their separation and quantification was successfully applied to evaluate the presence of these natural products in extracts obtained from the pulp and the exocarp of white grapefruits of different geographical origin. The recorded concentration values showed a great variation between the different sources, being the species richest in both secondary metabolites the one from South America. The set-up methodology showed LOQ values able to selectively quantify both GOFA and boropinic acid. Results described herein depict a potential chemopreventive dietary feeding role for grapefruits. (C) 2013 Phytochemical Society of Europe
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